Zinc in PDB 8ear: Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp

The structure of Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp also contains other interesting chemical elements:

Calcium

(Ca)

16 atoms

The binding sites of Zinc atom in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp (pdb code 8ear). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp, PDB code: 8ear:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2801 b:111.0 occ:1.00 SG A:CYS2614 2.3 85.0 1.0 NE2 A:HIS2631 2.3 91.5 1.0 SG A:CYS2611 2.3 82.5 1.0 CB A:HIS2636 3.0 86.9 1.0 CG A:HIS2636 3.1 86.9 1.0 CB A:CYS2614 3.1 85.0 1.0 CD2 A:HIS2631 3.2 91.5 1.0 CE1 A:HIS2631 3.2 91.5 1.0 CB A:CYS2611 3.4 82.5 1.0 CD2 A:HIS2636 3.5 86.9 1.0 ND1 A:HIS2636 3.7 86.9 1.0 N A:CYS2614 3.7 85.0 1.0 CA A:CYS2614 4.0 85.0 1.0 NE2 A:HIS2636 4.2 86.9 1.0 ND1 A:HIS2631 4.3 91.5 1.0 CG A:HIS2631 4.3 91.5 1.0 CE1 A:HIS2636 4.3 86.9 1.0 CA A:HIS2636 4.5 86.9 1.0 N6 A:ATP2802 4.6 87.9 1.0 O A:HIS2636 4.6 86.9 1.0 CZ A:PHE2621 4.8 101.4 1.0 CG2 A:ILE2632 4.8 82.1 1.0 CA A:CYS2611 4.9 82.5 1.0 O A:HIS2631 4.9 91.5 1.0 C A:ILE2613 4.9 77.6 1.0 N A:GLY2615 5.0 85.4 1.0 C A:CYS2614 5.0 85.0 1.0

Zinc binding site 2 out of 4 in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2801 b:111.0 occ:1.00 SG B:CYS2614 2.3 85.0 1.0 NE2 B:HIS2631 2.3 91.5 1.0 SG B:CYS2611 2.3 82.5 1.0 CB B:HIS2636 3.0 86.9 1.0 CG B:HIS2636 3.1 86.9 1.0 CB B:CYS2614 3.1 85.0 1.0 CD2 B:HIS2631 3.2 91.5 1.0 CE1 B:HIS2631 3.2 91.5 1.0 CB B:CYS2611 3.4 82.5 1.0 CD2 B:HIS2636 3.5 86.9 1.0 ND1 B:HIS2636 3.7 86.9 1.0 N B:CYS2614 3.7 85.0 1.0 CA B:CYS2614 4.0 85.0 1.0 NE2 B:HIS2636 4.2 86.9 1.0 ND1 B:HIS2631 4.3 91.5 1.0 CG B:HIS2631 4.3 91.5 1.0 CE1 B:HIS2636 4.3 86.9 1.0 CA B:HIS2636 4.5 86.9 1.0 N6 B:ATP2803 4.6 88.3 1.0 O B:HIS2636 4.6 86.9 1.0 CZ B:PHE2621 4.8 101.4 1.0 CG2 B:ILE2632 4.8 82.1 1.0 CA B:CYS2611 4.9 82.5 1.0 O B:HIS2631 4.9 91.5 1.0 C B:ILE2613 4.9 77.6 1.0 N B:GLY2615 5.0 85.4 1.0 C B:CYS2614 5.0 85.0 1.0

Zinc binding site 3 out of 4 in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2801 b:111.0 occ:1.00 SG C:CYS2614 2.3 85.0 1.0 NE2 C:HIS2631 2.3 91.5 1.0 SG C:CYS2611 2.3 82.5 1.0 CB C:HIS2636 3.0 86.9 1.0 CG C:HIS2636 3.1 86.9 1.0 CB C:CYS2614 3.1 85.0 1.0 CD2 C:HIS2631 3.2 91.5 1.0 CE1 C:HIS2631 3.2 91.5 1.0 CB C:CYS2611 3.4 82.5 1.0 CD2 C:HIS2636 3.5 86.9 1.0 ND1 C:HIS2636 3.7 86.9 1.0 N C:CYS2614 3.7 85.0 1.0 CA C:CYS2614 4.0 85.0 1.0 NE2 C:HIS2636 4.2 86.9 1.0 ND1 C:HIS2631 4.3 91.5 1.0 CG C:HIS2631 4.3 91.5 1.0 CE1 C:HIS2636 4.3 86.9 1.0 CA C:HIS2636 4.5 86.9 1.0 N6 C:ATP2807 4.6 88.3 1.0 O C:HIS2636 4.6 86.9 1.0 CZ C:PHE2621 4.8 101.4 1.0 CG2 C:ILE2632 4.8 82.1 1.0 CA C:CYS2611 4.9 82.5 1.0 O C:HIS2631 4.9 91.5 1.0 C C:ILE2613 4.9 77.6 1.0 N C:GLY2615 5.0 85.4 1.0 C C:CYS2614 5.0 85.0 1.0

Zinc binding site 4 out of 4 in the Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Full-Length IP3R1 Channel Determined in the Presence of Calcium/IP3/Atp within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2801 b:111.0 occ:1.00 SG D:CYS2614 2.3 85.0 1.0 NE2 D:HIS2631 2.3 91.5 1.0 SG D:CYS2611 2.3 82.5 1.0 CB D:HIS2636 3.0 86.9 1.0 CG D:HIS2636 3.1 86.9 1.0 CB D:CYS2614 3.1 85.0 1.0 CD2 D:HIS2631 3.2 91.5 1.0 CE1 D:HIS2631 3.2 91.5 1.0 CB D:CYS2611 3.4 82.5 1.0 CD2 D:HIS2636 3.5 86.9 1.0 ND1 D:HIS2636 3.7 86.9 1.0 N D:CYS2614 3.7 85.0 1.0 CA D:CYS2614 4.0 85.0 1.0 NE2 D:HIS2636 4.2 86.9 1.0 ND1 D:HIS2631 4.3 91.5 1.0 CG D:HIS2631 4.3 91.5 1.0 CE1 D:HIS2636 4.3 86.9 1.0 CA D:HIS2636 4.5 86.9 1.0 N6 D:ATP2803 4.6 88.7 1.0 O D:HIS2636 4.6 86.9 1.0 CZ D:PHE2621 4.8 101.4 1.0 CG2 D:ILE2632 4.8 82.1 1.0 CA D:CYS2611 4.9 82.5 1.0 O D:HIS2631 4.9 91.5 1.0 C D:ILE2613 4.9 77.6 1.0 N D:GLY2615 5.0 85.4 1.0 C D:CYS2614 5.0 85.0 1.0

G.Fan, M.R.Baker, L.E.Terry, V.Arige, M.Chen, A.B.Seryshev, M.L.Baker, S.J.Ludtke, D.I.Yule, I.I.Serysheva. Conformational Motions and Ligand-Binding Underlying Gating and Regulation in Ip 3 R Channel. Nat Commun V. 13 6942 2022.
ISSN: ESSN 2041-1723
PubMed: 36376291
DOI: 10.1038/S41467-022-34574-1