Zinc in PDB 8e40: Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna

All present enzymatic activity of Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna:
3.5.4.38;

The binding sites of Zinc atom in the Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna (pdb code 8e40). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna, PDB code: 8e40:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:35.7 occ:1.00 ND1 A:HIS65 2.3 37.5 1.0 SG A:CYS97 2.5 27.2 1.0 OE1 A:GLU67 2.6 37.3 1.0 CE1 A:HIS65 2.8 37.5 1.0 SG A:CYS100 2.9 32.9 1.0 CB A:CYS97 3.0 27.2 1.0 N A:CYS97 3.2 27.2 1.0 CB A:CYS100 3.4 32.9 1.0 CG A:HIS65 3.5 37.5 1.0 CD A:GLU67 3.7 37.3 1.0 CA A:CYS97 3.7 27.2 1.0 NE2 A:HIS65 4.0 37.5 1.0 C A:PRO96 4.1 27.2 1.0 CB A:HIS65 4.1 37.5 1.0 OE2 A:GLU67 4.2 37.3 1.0 CA A:PRO96 4.3 27.2 1.0 CD2 A:HIS65 4.3 37.5 1.0 CG A:GLU67 4.8 37.3 1.0 C A:CYS97 4.9 27.2 1.0 CA A:CYS100 4.9 32.9 1.0 O A:SER95 4.9 27.2 1.0

Zinc binding site 2 out of 2 in the Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Full-Length APOBEC3G in Complex with Hiv-1 Vif, Cbf-Beta, and Fork Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:89.6 occ:1.00 SG A:CYS287 2.3 60.8 1.0 ND1 A:HIS257 2.3 56.0 1.0 CG A:HIS257 2.7 56.0 1.0 CE1 A:HIS257 2.9 56.0 1.0 CB A:HIS257 3.2 56.0 1.0 SG A:CYS290 3.3 61.8 1.0 CD2 A:HIS257 3.4 56.0 1.0 NE2 A:HIS257 3.5 56.0 1.0 N A:ALA258 3.6 54.0 1.0 CB A:CYS287 3.8 60.8 1.0 CB A:ALA258 3.9 54.0 1.0 C A:HIS257 4.1 56.0 1.0 CA A:HIS257 4.2 56.0 1.0 CA A:ALA258 4.3 54.0 1.0 CB A:CYS290 4.3 61.8 1.0 CE2 A:TYR314 4.7 59.0 1.0 N A:CYS287 4.9 60.8 1.0 CA A:CYS287 4.9 60.8 1.0 O A:HIS257 4.9 56.0 1.0

F.Ito, A.L.Alvarez-Cabrera, S.Liu, H.Yang, A.Shiriaeva, Z.H.Zhou, X.S.Chen. Structural Basis For Hiv-1 Antagonism of Host APOBEC3G Via Cullin E3 Ligase. Sci Adv V. 9 E3168 2023.
ISSN: ESSN 2375-2548
PubMed: 36598981
DOI: 10.1126/SCIADV.ADE3168