Zinc in PDB 8e1d: uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
Enzymatic activity of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
All present enzymatic activity of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor:
2.3.1.48;
Zinc Binding Sites:
The binding sites of Zinc atom in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
(pdb code 8e1d). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the
uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor, PDB code: 8e1d:
Jump to Zinc binding site number:
1;
2;
3;
Zinc binding site 1 out
of 3 in 8e1d
Go back to
Zinc Binding Sites List in 8e1d
Zinc binding site 1 out
of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_01.jpg) Mono view
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1901
b:0.0
occ:1.00
|
NE2
|
A:HIS1744
|
2.0
|
0.0
|
1.0
|
SG
|
A:CYS1758
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1753
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1748
|
2.3
|
0.0
|
1.0
|
CE1
|
A:HIS1744
|
2.6
|
0.0
|
1.0
|
HE1
|
A:HIS1744
|
2.8
|
0.0
|
1.0
|
CD2
|
A:HIS1744
|
2.9
|
0.0
|
1.0
|
HB2
|
A:CYS1748
|
3.2
|
0.0
|
1.0
|
HB3
|
A:CYS1758
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1758
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1748
|
3.3
|
0.0
|
1.0
|
HB2
|
A:CYS1753
|
3.3
|
0.0
|
1.0
|
HD2
|
A:HIS1744
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1753
|
3.4
|
0.0
|
1.0
|
HB2
|
A:CYS1758
|
3.4
|
0.0
|
1.0
|
ND1
|
A:HIS1744
|
3.5
|
0.0
|
1.0
|
HB3
|
A:CYS1748
|
3.6
|
0.0
|
1.0
|
HB3
|
A:CYS1753
|
3.6
|
0.0
|
1.0
|
HG
|
A:LEU1755
|
3.7
|
0.0
|
1.0
|
CG
|
A:HIS1744
|
3.7
|
0.0
|
1.0
|
HA
|
A:ALA1745
|
4.1
|
0.0
|
1.0
|
HD12
|
A:LEU1755
|
4.3
|
0.0
|
1.0
|
HD1
|
A:HIS1744
|
4.3
|
0.0
|
1.0
|
HB3
|
A:ASN1750
|
4.4
|
0.0
|
1.0
|
CG
|
A:LEU1755
|
4.7
|
0.0
|
1.0
|
CA
|
A:CYS1748
|
4.7
|
0.0
|
1.0
|
CA
|
A:CYS1758
|
4.8
|
0.0
|
1.0
|
CA
|
A:CYS1753
|
4.8
|
0.0
|
1.0
|
HB3
|
A:LEU1755
|
4.8
|
0.0
|
1.0
|
CD1
|
A:LEU1755
|
4.9
|
0.0
|
1.0
|
O
|
A:HIS1744
|
4.9
|
0.0
|
1.0
|
HA
|
A:CYS1748
|
4.9
|
0.0
|
1.0
|
HA
|
A:CYS1753
|
4.9
|
0.0
|
1.0
|
HD13
|
A:LEU1755
|
5.0
|
0.0
|
1.0
|
H
|
A:LEU1755
|
5.0
|
0.0
|
1.0
|
C
|
A:HIS1744
|
5.0
|
0.0
|
1.0
|
CB
|
A:HIS1744
|
5.0
|
0.0
|
1.0
|
|
Zinc binding site 2 out
of 3 in 8e1d
Go back to
Zinc Binding Sites List in 8e1d
Zinc binding site 2 out
of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_02.jpg) Mono view
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1902
b:0.0
occ:1.00
|
NE2
|
A:HIS1767
|
2.0
|
0.0
|
1.0
|
SG
|
A:CYS1771
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1779
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1782
|
2.3
|
0.0
|
1.0
|
CE1
|
A:HIS1767
|
2.5
|
0.0
|
1.0
|
HE1
|
A:HIS1767
|
2.8
|
0.0
|
1.0
|
CD2
|
A:HIS1767
|
2.9
|
0.0
|
1.0
|
HB3
|
A:CYS1779
|
3.1
|
0.0
|
1.0
|
HB3
|
A:CYS1771
|
3.1
|
0.0
|
1.0
|
HB2
|
A:CYS1782
|
3.3
|
0.0
|
1.0
|
HA
|
A:THR1768
|
3.3
|
0.0
|
1.0
|
H
|
A:CYS1782
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1771
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1779
|
3.3
|
0.0
|
1.0
|
HD2
|
A:HIS1767
|
3.4
|
0.0
|
1.0
|
HG22
|
A:THR1768
|
3.4
|
0.0
|
1.0
|
HB2
|
A:LYS1774
|
3.4
|
0.0
|
1.0
|
CB
|
A:CYS1782
|
3.4
|
0.0
|
1.0
|
ND1
|
A:HIS1767
|
3.5
|
0.0
|
1.0
|
CG
|
A:HIS1767
|
3.7
|
0.0
|
1.0
|
HB2
|
A:CYS1771
|
3.7
|
0.0
|
1.0
|
HB2
|
A:CYS1779
|
3.9
|
0.0
|
1.0
|
HB
|
A:ILE1781
|
3.9
|
0.0
|
1.0
|
N
|
A:CYS1782
|
4.0
|
0.0
|
1.0
|
CA
|
A:CYS1782
|
4.2
|
0.0
|
1.0
|
HB3
|
A:CYS1782
|
4.3
|
0.0
|
1.0
|
CA
|
A:THR1768
|
4.3
|
0.0
|
1.0
|
HD1
|
A:HIS1767
|
4.3
|
0.0
|
1.0
|
CG2
|
A:THR1768
|
4.3
|
0.0
|
1.0
|
HA
|
A:CYS1779
|
4.4
|
0.0
|
1.0
|
CB
|
A:LYS1774
|
4.4
|
0.0
|
1.0
|
HA
|
A:CYS1782
|
4.5
|
0.0
|
1.0
|
CA
|
A:CYS1779
|
4.5
|
0.0
|
1.0
|
O
|
A:HIS1767
|
4.6
|
0.0
|
1.0
|
HB3
|
A:LYS1774
|
4.6
|
0.0
|
1.0
|
HA
|
A:CYS1771
|
4.6
|
0.0
|
1.0
|
CA
|
A:CYS1771
|
4.6
|
0.0
|
1.0
|
HG21
|
A:THR1768
|
4.6
|
0.0
|
1.0
|
N
|
A:THR1768
|
4.6
|
0.0
|
1.0
|
C
|
A:HIS1767
|
4.7
|
0.0
|
1.0
|
CB
|
A:THR1768
|
4.8
|
0.0
|
1.0
|
HB
|
A:THR1768
|
4.8
|
0.0
|
1.0
|
HD3
|
A:LYS1774
|
4.8
|
0.0
|
1.0
|
H
|
A:LYS1774
|
4.9
|
0.0
|
1.0
|
HZ
|
A:PHE1805
|
4.9
|
0.0
|
1.0
|
CB
|
A:ILE1781
|
5.0
|
0.0
|
1.0
|
|
Zinc binding site 3 out
of 3 in 8e1d
Go back to
Zinc Binding Sites List in 8e1d
Zinc binding site 3 out
of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_03.jpg) Mono view
![](/pictures/ZN/pdb/e1/8e1d-ZN-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1903
b:0.0
occ:1.00
|
NE2
|
A:HIS1792
|
2.0
|
0.0
|
1.0
|
SG
|
A:CYS1806
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1801
|
2.3
|
0.0
|
1.0
|
SG
|
A:CYS1796
|
2.3
|
0.0
|
1.0
|
CE1
|
A:HIS1792
|
2.5
|
0.0
|
1.0
|
HE1
|
A:HIS1792
|
2.7
|
0.0
|
1.0
|
CD2
|
A:HIS1792
|
2.9
|
0.0
|
1.0
|
HB3
|
A:CYS1801
|
3.2
|
0.0
|
1.0
|
HB3
|
A:CYS1796
|
3.3
|
0.0
|
1.0
|
HB2
|
A:CYS1806
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1801
|
3.3
|
0.0
|
1.0
|
CB
|
A:CYS1806
|
3.4
|
0.0
|
1.0
|
CB
|
A:CYS1796
|
3.4
|
0.0
|
1.0
|
HD2
|
A:HIS1792
|
3.4
|
0.0
|
1.0
|
ND1
|
A:HIS1792
|
3.5
|
0.0
|
1.0
|
HA
|
A:ALA1793
|
3.5
|
0.0
|
1.0
|
HB3
|
A:CYS1806
|
3.6
|
0.0
|
1.0
|
HB2
|
A:CYS1801
|
3.6
|
0.0
|
1.0
|
HB2
|
A:CYS1796
|
3.7
|
0.0
|
1.0
|
CG
|
A:HIS1792
|
3.7
|
0.0
|
1.0
|
HD2
|
A:PRO1802
|
4.0
|
0.0
|
1.0
|
HB3
|
A:ALA1793
|
4.2
|
0.0
|
1.0
|
HD1
|
A:HIS1792
|
4.2
|
0.0
|
1.0
|
CA
|
A:ALA1793
|
4.4
|
0.0
|
1.0
|
O
|
A:HIS1792
|
4.5
|
0.0
|
1.0
|
N
|
A:ALA1793
|
4.6
|
0.0
|
1.0
|
HG21
|
A:VAL1803
|
4.6
|
0.0
|
1.0
|
C
|
A:HIS1792
|
4.6
|
0.0
|
1.0
|
CB
|
A:ALA1793
|
4.7
|
0.0
|
1.0
|
CA
|
A:CYS1801
|
4.7
|
0.0
|
1.0
|
CA
|
A:CYS1796
|
4.8
|
0.0
|
1.0
|
CA
|
A:CYS1806
|
4.8
|
0.0
|
1.0
|
HD3
|
A:PRO1802
|
4.8
|
0.0
|
1.0
|
CD
|
A:PRO1802
|
4.8
|
0.0
|
1.0
|
HA
|
A:CYS1796
|
4.9
|
0.0
|
1.0
|
HA
|
A:CYS1801
|
4.9
|
0.0
|
1.0
|
HB1
|
A:ALA1793
|
4.9
|
0.0
|
1.0
|
HA
|
A:CYS1806
|
5.0
|
0.0
|
1.0
|
|
Reference:
A.D.Brown,
K.L.Vergunst,
M.Branch,
C.M.Blair,
D.J.Dupre,
G.S.Ballie,
D.N.Langelaan.
Structural Basis of Cbp/P300 Recruitment By the Microphthalmia-Associated Transcription Factor To Be Published.
Page generated: Fri Jul 28 06:51:23 2023
|