Zinc in PDB 8e1d: uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor

All present enzymatic activity of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor:
2.3.1.48;

The binding sites of Zinc atom in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor (pdb code 8e1d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor, PDB code: 8e1d:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1901 b:0.0 occ:1.00 NE2 A:HIS1744 2.0 0.0 1.0 SG A:CYS1758 2.3 0.0 1.0 SG A:CYS1753 2.3 0.0 1.0 SG A:CYS1748 2.3 0.0 1.0 CE1 A:HIS1744 2.6 0.0 1.0 HE1 A:HIS1744 2.8 0.0 1.0 CD2 A:HIS1744 2.9 0.0 1.0 HB2 A:CYS1748 3.2 0.0 1.0 HB3 A:CYS1758 3.3 0.0 1.0 CB A:CYS1758 3.3 0.0 1.0 CB A:CYS1748 3.3 0.0 1.0 HB2 A:CYS1753 3.3 0.0 1.0 HD2 A:HIS1744 3.3 0.0 1.0 CB A:CYS1753 3.4 0.0 1.0 HB2 A:CYS1758 3.4 0.0 1.0 ND1 A:HIS1744 3.5 0.0 1.0 HB3 A:CYS1748 3.6 0.0 1.0 HB3 A:CYS1753 3.6 0.0 1.0 HG A:LEU1755 3.7 0.0 1.0 CG A:HIS1744 3.7 0.0 1.0 HA A:ALA1745 4.1 0.0 1.0 HD12 A:LEU1755 4.3 0.0 1.0 HD1 A:HIS1744 4.3 0.0 1.0 HB3 A:ASN1750 4.4 0.0 1.0 CG A:LEU1755 4.7 0.0 1.0 CA A:CYS1748 4.7 0.0 1.0 CA A:CYS1758 4.8 0.0 1.0 CA A:CYS1753 4.8 0.0 1.0 HB3 A:LEU1755 4.8 0.0 1.0 CD1 A:LEU1755 4.9 0.0 1.0 O A:HIS1744 4.9 0.0 1.0 HA A:CYS1748 4.9 0.0 1.0 HA A:CYS1753 4.9 0.0 1.0 HD13 A:LEU1755 5.0 0.0 1.0 H A:LEU1755 5.0 0.0 1.0 C A:HIS1744 5.0 0.0 1.0 CB A:HIS1744 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:0.0 occ:1.00 NE2 A:HIS1767 2.0 0.0 1.0 SG A:CYS1771 2.3 0.0 1.0 SG A:CYS1779 2.3 0.0 1.0 SG A:CYS1782 2.3 0.0 1.0 CE1 A:HIS1767 2.5 0.0 1.0 HE1 A:HIS1767 2.8 0.0 1.0 CD2 A:HIS1767 2.9 0.0 1.0 HB3 A:CYS1779 3.1 0.0 1.0 HB3 A:CYS1771 3.1 0.0 1.0 HB2 A:CYS1782 3.3 0.0 1.0 HA A:THR1768 3.3 0.0 1.0 H A:CYS1782 3.3 0.0 1.0 CB A:CYS1771 3.3 0.0 1.0 CB A:CYS1779 3.3 0.0 1.0 HD2 A:HIS1767 3.4 0.0 1.0 HG22 A:THR1768 3.4 0.0 1.0 HB2 A:LYS1774 3.4 0.0 1.0 CB A:CYS1782 3.4 0.0 1.0 ND1 A:HIS1767 3.5 0.0 1.0 CG A:HIS1767 3.7 0.0 1.0 HB2 A:CYS1771 3.7 0.0 1.0 HB2 A:CYS1779 3.9 0.0 1.0 HB A:ILE1781 3.9 0.0 1.0 N A:CYS1782 4.0 0.0 1.0 CA A:CYS1782 4.2 0.0 1.0 HB3 A:CYS1782 4.3 0.0 1.0 CA A:THR1768 4.3 0.0 1.0 HD1 A:HIS1767 4.3 0.0 1.0 CG2 A:THR1768 4.3 0.0 1.0 HA A:CYS1779 4.4 0.0 1.0 CB A:LYS1774 4.4 0.0 1.0 HA A:CYS1782 4.5 0.0 1.0 CA A:CYS1779 4.5 0.0 1.0 O A:HIS1767 4.6 0.0 1.0 HB3 A:LYS1774 4.6 0.0 1.0 HA A:CYS1771 4.6 0.0 1.0 CA A:CYS1771 4.6 0.0 1.0 HG21 A:THR1768 4.6 0.0 1.0 N A:THR1768 4.6 0.0 1.0 C A:HIS1767 4.7 0.0 1.0 CB A:THR1768 4.8 0.0 1.0 HB A:THR1768 4.8 0.0 1.0 HD3 A:LYS1774 4.8 0.0 1.0 H A:LYS1774 4.9 0.0 1.0 HZ A:PHE1805 4.9 0.0 1.0 CB A:ILE1781 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of uc(Nmr)-Derived Ensemble of the TAZ2 Domain of P300 Bound to the Microphthalmia-Associated Transcription Factor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1903 b:0.0 occ:1.00 NE2 A:HIS1792 2.0 0.0 1.0 SG A:CYS1806 2.3 0.0 1.0 SG A:CYS1801 2.3 0.0 1.0 SG A:CYS1796 2.3 0.0 1.0 CE1 A:HIS1792 2.5 0.0 1.0 HE1 A:HIS1792 2.7 0.0 1.0 CD2 A:HIS1792 2.9 0.0 1.0 HB3 A:CYS1801 3.2 0.0 1.0 HB3 A:CYS1796 3.3 0.0 1.0 HB2 A:CYS1806 3.3 0.0 1.0 CB A:CYS1801 3.3 0.0 1.0 CB A:CYS1806 3.4 0.0 1.0 CB A:CYS1796 3.4 0.0 1.0 HD2 A:HIS1792 3.4 0.0 1.0 ND1 A:HIS1792 3.5 0.0 1.0 HA A:ALA1793 3.5 0.0 1.0 HB3 A:CYS1806 3.6 0.0 1.0 HB2 A:CYS1801 3.6 0.0 1.0 HB2 A:CYS1796 3.7 0.0 1.0 CG A:HIS1792 3.7 0.0 1.0 HD2 A:PRO1802 4.0 0.0 1.0 HB3 A:ALA1793 4.2 0.0 1.0 HD1 A:HIS1792 4.2 0.0 1.0 CA A:ALA1793 4.4 0.0 1.0 O A:HIS1792 4.5 0.0 1.0 N A:ALA1793 4.6 0.0 1.0 HG21 A:VAL1803 4.6 0.0 1.0 C A:HIS1792 4.6 0.0 1.0 CB A:ALA1793 4.7 0.0 1.0 CA A:CYS1801 4.7 0.0 1.0 CA A:CYS1796 4.8 0.0 1.0 CA A:CYS1806 4.8 0.0 1.0 HD3 A:PRO1802 4.8 0.0 1.0 CD A:PRO1802 4.8 0.0 1.0 HA A:CYS1796 4.9 0.0 1.0 HA A:CYS1801 4.9 0.0 1.0 HB1 A:ALA1793 4.9 0.0 1.0 HA A:CYS1806 5.0 0.0 1.0

A.D.Brown, K.L.Vergunst, M.Branch, C.M.Blair, D.J.Dupre, G.S.Ballie, D.N.Langelaan. Structural Basis of Cbp/P300 Recruitment By the Microphthalmia-Associated Transcription Factor To Be Published.