Zinc in PDB 8dso: Structure of CIAP1, Btk and Bccov

All present enzymatic activity of Structure of CIAP1, Btk and Bccov:
2.3.2.27; 2.7.10.2;

The structure of Structure of CIAP1, Btk and Bccov, PDB code: 8dso was solved by J.S.Schiemer, M.F.Calabrese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	110.29 / 2.33
Space group	P 3 2 1
Cell size a, b, c (Å), α, β, γ (°)	104.36, 104.36, 110.29, 90, 90, 120
R / Rfree (%)	24.2 / 29.2

The binding sites of Zinc atom in the Structure of CIAP1, Btk and Bccov (pdb code 8dso). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of CIAP1, Btk and Bccov, PDB code: 8dso:

Zinc binding site 1 out of 1 in the Structure of CIAP1, Btk and Bccov


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of CIAP1, Btk and Bccov within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn401 b:66.4 occ:1.00 NE2 D:HIS326 2.0 53.0 1.0 SG D:CYS333 2.2 73.1 1.0 SG D:CYS306 2.3 60.5 1.0 SG D:CYS309 2.5 57.2 1.0 CE1 D:HIS326 2.6 53.4 1.0 CB D:CYS306 3.1 55.3 1.0 CB D:CYS333 3.2 68.6 1.0 CD2 D:HIS326 3.3 52.5 1.0 CB D:CYS309 3.4 58.7 1.0 N D:CYS309 3.8 58.6 1.0 ND1 D:HIS326 3.9 53.4 1.0 CA D:CYS309 4.2 59.0 1.0 CG D:HIS326 4.2 52.1 1.0 CA D:CYS306 4.5 53.6 1.0 CA D:CYS333 4.6 67.4 1.0 CB D:CYS308 4.7 60.9 1.0 CB D:PHE330 4.9 65.2 1.0 C D:CYS308 4.9 59.0 1.0

J.Schiemer, A.Maxwell, R.Horst, S.Liu, D.P.Uccello, K.Borzilleri, N.Rajamohan, M.F.Brown, M.F.Calabrese. A Covalent Btk Ternary Complex Compatible with Targeted Protein Degradation Nat Commun V. 14 1189 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-36738-Z