Zinc in PDB 8d4a: CAS12A2 Quaternary Complex

The structure of CAS12A2 Quaternary Complex also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the CAS12A2 Quaternary Complex (pdb code 8d4a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the CAS12A2 Quaternary Complex, PDB code: 8d4a:

Zinc binding site 1 out of 1 in the CAS12A2 Quaternary Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of CAS12A2 Quaternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1301 b:58.9 occ:1.00 SG A:CYS1170 2.3 28.7 1.0 SG A:CYS1188 2.3 36.8 1.0 SG A:CYS1173 2.3 30.2 1.0 SG A:CYS1191 2.3 40.4 1.0 CB A:CYS1170 3.1 28.7 1.0 CB A:CYS1188 3.2 36.8 1.0 CB A:CYS1191 3.3 40.4 1.0 CB A:CYS1173 3.6 30.2 1.0 N A:CYS1173 4.0 30.2 1.0 N A:CYS1191 4.0 40.4 1.0 CA A:CYS1191 4.2 40.4 1.0 CB A:PHE1193 4.3 34.5 1.0 CA A:CYS1173 4.4 30.2 1.0 CA A:CYS1170 4.5 28.7 1.0 CA A:CYS1188 4.6 36.8 1.0 CB A:VAL1172 4.7 27.6 1.0 C A:GLU1190 4.8 42.7 1.0 C A:CYS1191 4.8 40.4 1.0 N A:PHE1193 4.9 34.5 1.0

J.P.K.Bravo, T.Hallmark, B.Naegle, C.L.Beisel, R.N.Jackson, D.W.Taylor. Rna Targeting Unleashes Indiscriminate Nuclease Activity of Crispr-CAS12A2. Nature 2023.
ISSN: ESSN 1476-4687
PubMed: 36599980
DOI: 10.1038/S41586-022-05560-W