Atomistry » Zinc » PDB 8c8u-8cna » 8cna
Atomistry »
  Zinc »
    PDB 8c8u-8cna »
      8cna »

Zinc in PDB 8cna: Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa

Enzymatic activity of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa

All present enzymatic activity of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa, PDB code: 8cna was solved by A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 72.25 / 2.46
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 86.825, 144.504, 154.62, 90, 90, 90
R / Rfree (%) 23.3 / 30.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa (pdb code 8cna). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa, PDB code: 8cna:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8cna

Go back to Zinc Binding Sites List in 8cna
Zinc binding site 1 out of 4 in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1801

b:39.2
occ:1.00
 SG A:CYS1200 2.2 32.0 1.0
ND1 A:HIS1291 2.2 29.9 1.0
SG A:CYS1199 2.2 34.3 1.0
SG A:CYS1294 2.3 45.9 1.0
CG A:HIS1291 3.0 33.8 1.0
CB A:HIS1291 3.1 47.6 1.0
CB A:CYS1294 3.2 20.8 1.0
CE1 A:HIS1291 3.4 35.3 1.0
CB A:CYS1199 3.4 30.0 1.0
N A:CYS1200 3.5 44.5 1.0
CB A:CYS1200 3.5 29.1 1.0
C A:CYS1199 4.0 47.3 1.0
CA A:CYS1200 4.1 23.6 1.0
N A:HIS1291 4.2 38.6 1.0
CD2 A:HIS1291 4.2 33.6 1.0
CA A:HIS1291 4.3 42.8 1.0
CA A:CYS1199 4.3 37.8 1.0
NE2 A:HIS1291 4.4 30.7 1.0
CE2 A:TYR1204 4.4 36.0 1.0
NH2 A:ARG1682 4.5 24.6 1.0
CA A:CYS1294 4.6 27.7 1.0
C A:CYS1200 4.7 19.4 1.0
O A:CYS1200 4.7 30.5 1.0
O A:CYS1199 4.7 50.0 1.0
CH2 A:TRP1151 4.8 22.8 1.0
CD2 A:TYR1204 4.9 43.3 1.0

Zinc binding site 2 out of 4 in 8cna

Go back to Zinc Binding Sites List in 8cna
Zinc binding site 2 out of 4 in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1802

b:64.7
occ:1.00
 SG A:CYS1311 2.1 65.3 1.0
SG A:CYS1308 2.1 67.0 1.0
SG A:CYS1283 2.4 52.1 1.0
SG A:CYS1286 2.7 53.9 1.0
CB A:CYS1311 2.9 55.3 1.0
CB A:CYS1286 3.2 50.5 1.0
CB A:CYS1308 3.3 54.1 1.0
CB A:CYS1283 3.6 52.3 1.0
N A:CYS1308 3.8 58.9 1.0
N A:CYS1286 3.8 62.8 1.0
CA A:CYS1311 4.1 49.9 1.0
N A:CYS1311 4.1 58.3 1.0
CA A:CYS1308 4.1 58.0 1.0
CA A:CYS1286 4.1 50.3 1.0
C A:GLU1285 4.5 59.9 1.0
NH1 A:ARG1288 4.6 62.5 1.0
CB A:GLU1285 4.6 47.5 1.0
C A:CYS1308 4.9 64.7 1.0
C A:VAL1307 4.9 58.2 1.0
CA A:GLU1285 5.0 43.0 1.0
CA A:CYS1283 5.0 49.1 1.0
N A:GLU1285 5.0 47.5 1.0
C A:CYS1286 5.0 47.5 1.0

Zinc binding site 3 out of 4 in 8cna

Go back to Zinc Binding Sites List in 8cna
Zinc binding site 3 out of 4 in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1803

b:97.7
occ:1.00
 O A:CYS1729 2.5 114.4 1.0
SG A:CYS1710 2.6 125.0 1.0
CB A:CYS1710 2.9 115.7 1.0
CB A:CYS1729 3.4 107.7 1.0
C A:CYS1729 3.5 108.5 1.0
SG A:CYS1707 3.6 91.9 1.0
CD2 A:LEU1728 3.8 86.4 1.0
CA A:CYS1729 3.8 112.0 1.0
N A:CYS1710 4.0 112.5 1.0
N A:CYS1729 4.0 116.7 1.0
CA A:CYS1710 4.1 105.3 1.0
SG A:CYS1729 4.3 105.0 1.0
ND1 A:HIS1712 4.5 73.2 1.0
O A:ILE1730 4.6 74.1 1.0
CB A:ASN1731 4.7 87.6 1.0
C A:GLU1709 4.7 104.4 1.0
N A:ILE1730 4.8 95.5 1.0
CB A:GLU1709 4.8 81.9 1.0
CB A:CYS1707 4.8 96.1 1.0
C A:ILE1730 4.9 89.8 1.0
OD1 A:ASN1731 5.0 85.0 1.0

Zinc binding site 4 out of 4 in 8cna

Go back to Zinc Binding Sites List in 8cna
Zinc binding site 4 out of 4 in the Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1804

b:125.0
occ:1.00
 ND1 A:HIS1740 1.9 203.8 1.0
CG A:HIS1740 2.3 198.2 1.0
SG A:CYS1723 2.3 109.4 1.0
SG A:CYS1720 2.5 134.2 1.0
CE1 A:HIS1740 2.7 205.3 1.0
CB A:HIS1740 2.8 185.1 1.0
CD2 A:HIS1740 3.1 202.2 1.0
NE2 A:HIS1738 3.2 107.9 1.0
CB A:CYS1720 3.3 120.9 1.0
NE2 A:HIS1740 3.3 203.6 1.0
CD2 A:TYR1726 3.5 78.0 1.0
CB A:CYS1723 3.6 98.0 1.0
CE1 A:HIS1738 3.8 109.4 1.0
CE2 A:TYR1726 4.2 77.9 1.0
N A:CYS1723 4.2 104.2 1.0
CA A:HIS1740 4.3 172.0 1.0
CD2 A:HIS1738 4.4 107.2 1.0
CG A:TYR1726 4.4 85.1 1.0
CA A:CYS1723 4.4 101.2 1.0
CB A:TYR1726 4.5 93.0 1.0
N A:HIS1740 4.6 166.0 1.0
CA A:CYS1720 4.7 106.2 1.0
CG1 A:VAL1722 4.8 85.4 1.0

Reference:

A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima. Crystal Structure of Crebbp-R1446C Histone Acetyltransferase Domain in Complex with A Bisubstrate Inhibitor, Lys-Coa To Be Published.
Page generated: Wed Oct 30 18:49:08 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy