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Zinc in PDB 8cn0: Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A

Enzymatic activity of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A

All present enzymatic activity of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A:
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8cn0 was solved by A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 75.89 / 2.44
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 87.009, 148.586, 155.125, 90, 90, 90
R / Rfree (%) 25.8 / 30.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A (pdb code 8cn0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A, PDB code: 8cn0:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 8cn0

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Zinc binding site 1 out of 5 in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1801

b:75.3
occ:0.50
 SG A:CYS1444 3.1 70.9 0.5
SG A:CYS1444 3.1 70.9 0.5
NE2 A:HIS1351 3.2 71.0 1.0
CD2 A:HIS1351 3.6 68.9 1.0
CE1 A:HIS1351 4.3 74.4 1.0
CB A:CYS1444 4.6 66.2 0.5
CB A:CYS1444 4.6 66.2 0.5
CG A:HIS1351 4.9 71.6 1.0
CB A:PRO1442 4.9 60.9 1.0

Zinc binding site 2 out of 5 in 8cn0

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Zinc binding site 2 out of 5 in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1802

b:52.1
occ:1.00
 ND1 A:HIS1291 2.0 24.3 1.0
O A:HOH1922 2.0 45.5 1.0
SG A:CYS1200 2.3 47.3 1.0
SG A:CYS1199 2.3 37.0 1.0
SG A:CYS1294 2.5 41.8 1.0
CG A:HIS1291 2.9 32.9 1.0
CE1 A:HIS1291 3.0 30.4 1.0
CB A:HIS1291 3.2 37.3 1.0
CB A:CYS1199 3.3 35.6 1.0
CB A:CYS1294 3.4 31.4 1.0
CB A:CYS1200 3.5 40.0 1.0
N A:CYS1200 3.6 46.0 1.0
C A:CYS1199 3.9 46.1 1.0
CD2 A:HIS1291 4.1 28.5 1.0
CA A:CYS1200 4.1 35.8 1.0
NE2 A:HIS1291 4.1 31.2 1.0
CA A:CYS1199 4.2 37.9 1.0
N A:HIS1291 4.3 33.0 1.0
CA A:HIS1291 4.4 34.7 1.0
C A:CYS1200 4.5 29.8 1.0
O A:CYS1199 4.6 44.6 1.0
CH2 A:TRP1151 4.6 34.5 1.0
O A:CYS1200 4.6 30.3 1.0
CE2 A:TYR1204 4.6 31.4 1.0
NH2 A:ARG1682 4.7 23.9 1.0
CA A:CYS1294 4.8 33.0 1.0
CZ2 A:TRP1151 4.9 33.9 1.0
N A:CYS1199 4.9 39.7 1.0
CD2 A:TYR1204 5.0 33.1 1.0

Zinc binding site 3 out of 5 in 8cn0

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Zinc binding site 3 out of 5 in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1803

b:64.5
occ:1.00
 SG A:CYS1286 2.0 69.8 1.0
SG A:CYS1308 2.0 59.9 1.0
SG A:CYS1283 2.1 62.0 1.0
SG A:CYS1311 2.4 62.7 1.0
CB A:CYS1308 2.6 49.0 1.0
CB A:CYS1286 3.0 51.8 1.0
N A:CYS1286 3.2 60.3 1.0
CB A:CYS1283 3.2 48.8 1.0
CB A:CYS1311 3.5 57.4 1.0
CA A:CYS1286 3.6 55.4 1.0
N A:CYS1308 3.8 53.2 1.0
CA A:CYS1308 3.8 52.7 1.0
C A:GLU1285 4.3 60.3 1.0
CB A:GLU1285 4.5 59.6 1.0
C A:CYS1308 4.6 57.3 1.0
CA A:CYS1283 4.6 46.7 1.0
N A:CYS1311 4.6 68.0 1.0
CA A:CYS1311 4.7 58.5 1.0
CA A:GLU1285 4.7 56.4 1.0
O A:CYS1308 4.8 63.3 1.0
N A:GLU1285 4.9 54.1 1.0
C A:CYS1286 4.9 54.9 1.0
C A:VAL1307 5.0 54.1 1.0

Zinc binding site 4 out of 5 in 8cn0

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Zinc binding site 4 out of 5 in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1804

b:159.5
occ:1.00
 O A:HOH1923 2.5 96.1 1.0
CB A:CYS1710 2.6 102.3 1.0
CB A:CYS1729 2.6 126.4 1.0
SG A:CYS1710 2.8 84.3 1.0
SG A:CYS1729 2.9 116.8 1.0
SG A:CYS1707 2.9 109.8 1.0
CB A:CYS1707 3.7 110.5 1.0
CA A:CYS1729 4.0 125.8 1.0
CA A:CYS1710 4.0 106.8 1.0
SG A:CYS1732 4.1 118.3 1.0
N A:CYS1710 4.2 112.0 1.0
N A:CYS1729 4.2 125.5 1.0
CB A:ASN1731 4.7 97.3 1.0
C A:CYS1710 4.8 104.9 1.0
C A:CYS1729 4.8 120.8 1.0
CB A:HIS1712 5.0 101.9 1.0

Zinc binding site 5 out of 5 in 8cn0

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Zinc binding site 5 out of 5 in the Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1805

b:193.1
occ:1.00
 NE2 A:HIS1738 1.1 154.9 1.0
ND1 A:HIS1740 2.0 196.5 1.0
CE1 A:HIS1740 2.1 206.9 1.0
CE1 A:HIS1738 2.1 147.1 1.0
CD2 A:HIS1738 2.3 146.6 1.0
SG A:CYS1720 2.5 150.2 1.0
CG A:HIS1740 3.0 196.6 1.0
NE2 A:HIS1740 3.1 207.4 1.0
ND1 A:HIS1738 3.2 154.1 1.0
SG A:CYS1723 3.3 119.5 1.0
CG A:HIS1738 3.3 142.4 1.0
CD2 A:HIS1740 3.5 207.5 1.0
CB A:CYS1720 3.7 130.1 1.0
CD1 A:TYR1726 3.9 114.6 1.0
CE1 A:TYR1726 3.9 114.9 1.0
CG A:TYR1726 4.0 116.6 1.0
CB A:HIS1740 4.0 174.8 1.0
CZ A:TYR1726 4.0 109.8 1.0
CD2 A:TYR1726 4.1 112.4 1.0
CE2 A:TYR1726 4.1 107.2 1.0
CB A:CYS1723 4.5 117.5 1.0
CE A:MET1742 4.5 120.7 1.0
OH A:TYR1726 4.7 110.9 1.0
CB A:TYR1726 4.7 114.8 1.0
CB A:HIS1738 4.7 134.2 1.0
CG2 A:VAL1722 4.8 136.7 1.0
N A:HIS1740 4.8 181.3 1.0
CA A:CYS1720 5.0 126.9 1.0

Reference:

A.E.Mechaly, W.Zhang, A.Haouz, M.Green, F.Rodrigues-Lima. Crystal Structure of Crebbp-Y1482N Histone Acetyltransferase Domain in Complex with Coenzyme A To Be Published.
Page generated: Wed Oct 30 18:48:38 2024

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