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Zinc in PDB 8c8v: Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue

Enzymatic activity of Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue

All present enzymatic activity of Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue:
6.1.1.5;

Protein crystallography data

The structure of Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue, PDB code: 8c8v was solved by A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.31 / 2.20
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 108.15, 108.15, 240.18, 90, 90, 90
R / Rfree (%) 19.6 / 22.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue (pdb code 8c8v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue, PDB code: 8c8v:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8c8v

Go back to Zinc Binding Sites List in 8c8v
Zinc binding site 1 out of 2 in the Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1101

b:44.8
occ:1.00
 SG A:CYS181 2.3 43.2 1.0
SG A:CYS387 2.3 44.3 1.0
SG A:CYS184 2.3 46.3 1.0
SG A:CYS390 2.3 48.4 1.0
CB A:CYS387 3.0 46.7 1.0
CB A:CYS184 3.3 45.4 1.0
CB A:CYS390 3.5 44.1 1.0
CB A:CYS181 3.5 44.0 1.0
N A:CYS184 3.7 48.5 1.0
N A:CYS390 4.0 45.0 1.0
CA A:CYS184 4.1 41.8 1.0
O A:HOH1287 4.2 48.3 1.0
CA A:CYS390 4.3 50.2 1.0
CA A:CYS387 4.5 50.5 1.0
CB A:SER183 4.5 41.7 1.0
C A:SER183 4.8 48.7 1.0
CB A:SER392 4.8 47.0 1.0
CA A:CYS181 4.9 46.5 1.0
C A:CYS390 4.9 51.5 1.0

Zinc binding site 2 out of 2 in 8c8v

Go back to Zinc Binding Sites List in 8c8v
Zinc binding site 2 out of 2 in the Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Priestia Megaterium Mupirocin-Resistant Isoleucyl-Trna Synthetase 2 with A Fully-Resolved C-Terminal Trna-Binding Domain Complexed with An Isoleucyl-Adenylate Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1102

b:42.9
occ:1.00
 SG A:CYS500 2.3 41.8 1.0
SG A:CYS462 2.3 45.0 1.0
SG A:CYS459 2.3 38.9 1.0
SG A:CYS503 2.3 41.2 1.0
CB A:CYS459 3.1 34.8 1.0
CB A:CYS500 3.2 41.3 1.0
CB A:CYS462 3.5 39.2 1.0
CB A:CYS503 3.5 44.0 1.0
N A:CYS503 3.7 48.2 1.0
N A:CYS462 3.7 44.4 1.0
CA A:CYS462 4.1 46.7 1.0
CA A:CYS503 4.1 49.5 1.0
CB A:VAL502 4.3 51.9 1.0
N A:GLY505 4.5 46.1 1.0
CB A:HIS464 4.5 40.0 1.0
CA A:CYS459 4.6 40.6 1.0
CA A:CYS500 4.6 42.2 1.0
C A:CYS503 4.6 47.4 1.0
C A:CYS462 4.7 45.9 1.0
C A:VAL502 4.7 54.3 1.0
C A:GLY461 4.7 50.2 1.0
N A:SER504 4.8 51.4 1.0
CG1 A:VAL502 4.8 41.6 1.0
N A:GLN463 4.9 42.8 1.0
CA A:GLY505 4.9 45.0 1.0
CA A:GLY461 4.9 45.3 1.0
CA A:VAL502 4.9 52.9 1.0
N A:HIS464 4.9 42.3 1.0
N A:VAL502 4.9 52.2 1.0
N A:GLY461 5.0 41.0 1.0

Reference:

A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj. Antibiotic Hyper-Resistance in A Class I Aminoacyl-Trna Synthetase with Altered Active Site Signature Motif To Be Published.
Page generated: Fri Aug 22 08:51:06 2025

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