Zinc in PDB 8bzn: Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I

The structure of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I, PDB code: 8bzn was solved by H.Wang, S.R.A.Rizvi, D.Dong, J.Lou, Q.Wang, W.Sopipong, F.Najar, P.K.Agarwal, F.Kozielski, S.Haider, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	52.43 / 2.19
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	104.867, 104.867, 104.867, 90, 90, 90
R / Rfree (%)	18 / 23.5

The structure of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I also contains other interesting chemical elements:

Chlorine

(Cl)

3 atoms

The binding sites of Zinc atom in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I (pdb code 8bzn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I, PDB code: 8bzn:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:38.8 occ:1.00 NE2 A:HIS83 2.0 40.5 1.0 SG A:CYS74 2.3 35.5 1.0 SG A:CYS90 2.3 37.7 1.0 SG A:CYS77 2.3 38.7 1.0 CE1 A:HIS83 2.9 42.3 1.0 CD2 A:HIS83 2.9 35.3 1.0 CB A:CYS74 3.1 32.4 1.0 CB A:CYS90 3.2 37.6 1.0 CB A:CYS77 3.4 34.4 1.0 N A:CYS77 3.6 31.1 1.0 CA A:CYS77 4.0 34.8 1.0 ND1 A:HIS83 4.0 40.3 1.0 CG A:HIS83 4.1 45.7 1.0 O A:HOH360 4.4 47.0 1.0 CB A:TYR76 4.5 33.0 1.0 CA A:CYS90 4.5 53.8 1.0 C A:TYR76 4.6 34.3 1.0 CA A:CYS74 4.6 34.0 1.0 CB A:LYS93 4.8 40.9 1.0 N A:LYS93 4.9 43.9 1.0 CA A:TYR76 4.9 30.8 1.0 N A:TYR76 5.0 29.0 1.0 C A:CYS74 5.0 31.2 1.0

Zinc binding site 2 out of 2 in the Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Non-Structural Protein 10 (NSP10) Variant T102I within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:79.0 occ:1.00 SG A:CYS128 2.3 71.8 1.0 SG A:CYS130 2.3 90.7 1.0 SG A:CYS120 2.3 74.7 1.0 SG A:CYS117 2.3 63.6 1.0 CB A:CYS117 3.1 61.8 1.0 CB A:CYS120 3.3 62.3 1.0 CB A:CYS128 3.3 66.2 1.0 CB A:CYS130 3.3 84.7 1.0 N A:CYS120 3.7 71.9 1.0 CA A:CYS128 4.0 70.6 1.0 CA A:CYS120 4.1 67.1 1.0 CB A:VAL119 4.3 71.1 1.0 N A:CYS130 4.3 85.4 1.0 CA A:CYS130 4.4 85.3 1.0 C A:CYS128 4.5 75.0 1.0 CA A:CYS117 4.6 62.5 1.0 N A:SER129 4.6 75.8 1.0 C A:VAL119 4.7 73.6 1.0 C A:CYS120 4.8 57.9 1.0 CG2 A:VAL119 4.9 79.5 1.0 CA A:VAL119 4.9 69.1 1.0 N A:VAL119 4.9 69.8 1.0

H.Wang, S.R.A.Rizvi, D.Dong, J.Lou, Q.Wang, W.Sopipong, F.Najar, P.K.Agarwal, F.Kozielski, S.Haider. Emerging Variants of Sars-Cov-2 NSP10 Highlight Strong Functional Conservation of Its Binding to Two Non-Structural Proteins, NSP14 and NSP16 To Be Published.