Zinc in PDB 8ams: Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin

All present enzymatic activity of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin:
2.3.2.23; 2.3.2.24; 2.3.2.27;

The structure of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin, PDB code: 8ams was solved by C.Perez-Borrajero, I.Kotova, B.Murciano, J.Hennig, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.92 / 2.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.12, 69.27, 151.87, 90, 90, 90
R / Rfree (%)	21.4 / 23.3

The binding sites of Zinc atom in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin (pdb code 8ams). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin, PDB code: 8ams:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:40.8 occ:1.00 ND1 C:HIS40 2.0 27.2 1.0 SG C:CYS60 2.3 41.6 1.0 SG C:CYS63 2.3 42.8 1.0 SG C:CYS38 2.4 47.6 1.0 CE1 C:HIS40 2.9 32.5 1.0 CG C:HIS40 3.0 34.5 1.0 CB C:CYS63 3.0 44.3 1.0 CB C:CYS60 3.2 39.5 1.0 CB C:CYS38 3.2 46.3 1.0 CB C:HIS40 3.4 37.2 1.0 N C:CYS63 3.7 37.1 1.0 CA C:CYS63 3.9 41.8 1.0 NE2 C:HIS40 4.0 31.4 1.0 CD2 C:HIS40 4.1 35.3 1.0 CA C:CYS38 4.5 34.3 1.0 C C:CYS63 4.6 39.6 1.0 N C:HIS40 4.6 42.5 1.0 O C:CYS38 4.6 43.5 1.0 CA C:CYS60 4.6 35.4 1.0 CA C:HIS40 4.6 42.5 1.0 O C:HOH318 4.6 45.1 1.0 CB C:VAL62 4.6 37.8 1.0 C C:CYS38 4.7 37.0 1.0 C C:VAL62 4.7 44.8 1.0 N C:ARG64 4.8 35.5 1.0 CG1 C:VAL62 5.0 38.2 1.0

Zinc binding site 2 out of 4 in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn202 b:38.7 occ:1.00 SG C:CYS46 2.2 38.2 1.0 SG C:CYS26 2.3 35.7 1.0 SG C:CYS23 2.4 32.1 1.0 SG C:CYS43 2.4 36.8 1.0 CB C:CYS23 2.9 28.1 1.0 CB C:CYS43 3.2 33.8 1.0 CB C:CYS46 3.4 26.1 1.0 CB C:CYS26 3.4 43.0 1.0 N C:CYS26 3.7 32.5 1.0 N C:CYS43 3.9 36.4 1.0 CA C:CYS43 4.1 47.0 1.0 CA C:CYS26 4.2 31.8 1.0 CA C:CYS23 4.4 31.6 1.0 CB C:ILE25 4.6 35.1 1.0 CA C:CYS46 4.7 36.5 1.0 C C:ILE25 4.8 47.9 1.0 C C:CYS23 4.8 34.7 1.0 N C:ILE25 4.9 41.0 1.0 O C:CYS23 5.0 31.7 1.0

Zinc binding site 3 out of 4 in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn201 b:42.2 occ:1.00 ND1 D:HIS40 2.1 33.1 1.0 SG D:CYS38 2.3 38.9 1.0 SG D:CYS63 2.4 39.8 1.0 SG D:CYS60 2.4 39.1 1.0 CB D:CYS63 2.8 42.4 1.0 CE1 D:HIS40 2.9 37.3 1.0 CB D:CYS60 3.1 36.3 1.0 CG D:HIS40 3.1 37.8 1.0 CB D:CYS38 3.2 40.5 1.0 CB D:HIS40 3.5 41.9 1.0 N D:CYS63 3.7 37.4 1.0 CA D:CYS63 3.8 39.4 1.0 NE2 D:HIS40 4.1 31.9 1.0 CD2 D:HIS40 4.2 29.0 1.0 C D:CYS63 4.5 36.4 1.0 CA D:CYS38 4.5 34.8 1.0 CA D:CYS60 4.6 28.8 1.0 O D:CYS38 4.6 44.1 1.0 N D:HIS40 4.7 37.3 1.0 N D:ARG64 4.7 35.7 1.0 CB D:VAL62 4.7 48.1 1.0 C D:CYS38 4.7 35.8 1.0 CA D:HIS40 4.8 31.6 1.0 C D:VAL62 4.8 50.4 1.0 O D:HOH312 5.0 43.6 1.0

Zinc binding site 4 out of 4 in the Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Complex of Human TRIM2 Ring Domain, UBCH5C, and Ubiquitin within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn202 b:41.6 occ:1.00 SG D:CYS43 2.3 45.0 1.0 SG D:CYS26 2.3 42.5 1.0 SG D:CYS23 2.4 44.3 1.0 SG D:CYS46 2.4 42.8 1.0 CB D:CYS23 2.9 30.7 1.0 CB D:CYS43 3.2 26.5 1.0 CB D:CYS26 3.5 48.8 1.0 CB D:CYS46 3.6 32.3 1.0 N D:CYS26 3.8 37.4 1.0 N D:CYS43 3.8 28.6 1.0 CA D:CYS43 4.1 38.8 1.0 CA D:CYS26 4.2 39.1 1.0 CA D:CYS23 4.4 39.0 1.0 CB D:ILE25 4.7 39.0 1.0 CA D:CYS46 4.8 40.5 1.0 C D:CYS23 4.9 35.2 1.0 C D:ILE25 4.9 51.7 1.0 N D:ILE25 5.0 42.2 1.0 C D:CYS43 5.0 46.9 1.0

C.Perez-Borrajero, J.Hennig. Structural and Biophysical Studies of TRIM2 and TRIM3 To Be Published.