Zinc in PDB 8alz: Cryo-Em Structure of ASCC3 in Complex with ASC1

All present enzymatic activity of Cryo-Em Structure of ASCC3 in Complex with ASC1:
3.6.4.12;

The binding sites of Zinc atom in the Cryo-Em Structure of ASCC3 in Complex with ASC1 (pdb code 8alz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of ASCC3 in Complex with ASC1, PDB code: 8alz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of ASCC3 in Complex with ASC1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of ASCC3 in Complex with ASC1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:164.3 occ:1.00 NE2 A:HIS178 2.1 132.1 1.0 SG A:CYS192 2.3 134.4 1.0 SG A:CYS171 2.3 149.0 1.0 SG A:CYS173 2.3 118.4 1.0 CE1 A:HIS178 2.7 132.1 1.0 CB A:CYS192 2.9 134.4 1.0 CD2 A:HIS178 3.3 132.1 1.0 CB A:CYS173 3.3 118.4 1.0 CB A:CYS171 3.4 149.0 1.0 ND1 A:HIS178 3.9 132.1 1.0 N A:CYS173 4.0 118.4 1.0 O A:CYS171 4.1 149.0 1.0 CB A:GLN194 4.1 140.9 1.0 C A:CYS171 4.2 149.0 1.0 CG A:HIS178 4.2 132.1 1.0 CA A:CYS173 4.3 118.4 1.0 CA A:CYS192 4.4 134.4 1.0 CA A:CYS171 4.5 149.0 1.0 N A:ASP172 4.8 131.0 1.0 CG A:GLN194 4.8 140.9 1.0 OE1 A:GLN194 4.8 140.9 1.0 OE2 A:GLU195 4.8 156.9 1.0 C A:ASP172 4.8 131.0 1.0 NZ A:LYS177 4.9 124.4 1.0 N A:CYS192 4.9 134.4 1.0 N A:LEU174 4.9 102.3 1.0 N A:GLN194 5.0 140.9 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of ASCC3 in Complex with ASC1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of ASCC3 in Complex with ASC1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:152.9 occ:1.00 SG A:CYS203 2.3 132.5 1.0 SG A:CYS187 2.3 110.7 1.0 SG A:CYS184 2.3 122.0 1.0 SG A:CYS200 2.3 143.5 1.0 CB A:CYS203 2.9 132.5 1.0 CB A:CYS184 3.5 122.0 1.0 CB A:CYS187 3.5 110.7 1.0 N A:CYS203 3.5 132.5 1.0 CA A:CYS203 3.7 132.5 1.0 N A:CYS187 3.8 110.7 1.0 CB A:CYS200 3.8 143.5 1.0 OG1 A:THR205 3.9 150.0 1.0 CB A:ILE186 4.1 105.2 1.0 CA A:CYS187 4.3 110.7 1.0 CG2 A:ILE186 4.3 105.2 1.0 C A:CYS203 4.3 132.5 1.0 N A:GLY204 4.4 141.5 1.0 C A:PHE202 4.6 108.8 1.0 CB A:PHE202 4.6 108.8 1.0 C A:ILE186 4.6 105.2 1.0 CA A:ILE186 4.7 105.2 1.0 N A:ILE186 4.8 105.2 1.0 CA A:CYS184 4.9 122.0 1.0 N A:THR205 4.9 150.0 1.0 CA A:PHE202 5.0 108.8 1.0

J.Jia, T.Hilal, B.Loll, M.C.Wahl. Cryo-Em Structure of ASCC3 in Complex with ASC1 Nat Commun 2023.
ISSN: ESSN 2041-1723