Zinc in PDB 7zwc: Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter

All present enzymatic activity of Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter:
2.3.1.48;

The binding sites of Zinc atom in the Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter (pdb code 7zwc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter, PDB code: 7zwc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter within 5.0Å range: probe atom residue distance (Å) B Occ b:Zn501 b:80.0 occ:1.00 NE2 b:HIS313 2.0 66.3 1.0 NE2 b:HIS319 2.0 63.5 1.0 SG b:CYS317 2.3 65.6 1.0 SG b:CYS221 2.3 71.2 1.0 CE1 b:HIS313 2.6 66.3 1.0 CE1 b:HIS319 2.8 63.5 1.0 CB b:CYS221 2.9 71.2 1.0 CD2 b:HIS319 3.1 63.5 1.0 CD2 b:HIS313 3.3 66.3 1.0 ND1 b:HIS313 3.9 66.3 1.0 CB b:CYS317 3.9 65.6 1.0 ND1 b:HIS319 4.0 63.5 1.0 OG b:SER223 4.0 69.3 1.0 CB b:SER223 4.1 69.3 1.0 CG b:HIS319 4.2 63.5 1.0 CG b:HIS313 4.2 66.3 1.0 CA b:CYS221 4.4 71.2 1.0 O b:CYS317 4.8 65.6 1.0 C b:CYS317 4.9 65.6 1.0 N b:SER223 4.9 69.3 1.0 C b:CYS221 5.0 71.2 1.0 CA b:CYS317 5.0 65.6 1.0

Zinc binding site 2 out of 2 in the Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Snapc:Tbp-Tfiia-Tfiib Sub-Complex Bound to U5 Snrna Promoter within 5.0Å range: probe atom residue distance (Å) B Occ b:Zn502 b:85.1 occ:1.00 SG b:CYS380 2.3 75.2 1.0 SG b:CYS383 2.3 79.1 1.0 SG b:CYS357 2.3 80.9 1.0 SG b:CYS354 2.3 74.9 1.0 CB b:CYS354 3.1 74.9 1.0 CB b:CYS383 3.2 79.1 1.0 CB b:CYS357 3.5 80.9 1.0 N b:CYS357 3.7 80.9 1.0 CB b:CYS380 3.9 75.2 1.0 O b:CYS357 4.0 80.9 1.0 CA b:CYS357 4.1 80.9 1.0 N b:CYS380 4.1 75.2 1.0 N b:CYS383 4.3 79.1 1.0 CB b:VAL356 4.3 77.3 1.0 CA b:CYS383 4.4 79.1 1.0 C b:CYS357 4.5 80.9 1.0 NE2 c:GLN338 4.5 82.4 1.0 CA b:CYS354 4.6 74.9 1.0 CA b:CYS380 4.6 75.2 1.0 CD2 b:TYR360 4.6 82.0 1.0 C b:VAL356 4.7 77.3 1.0 CG1 b:VAL356 4.9 77.3 1.0 CA b:VAL356 4.9 77.3 1.0 N b:VAL356 5.0 77.3 1.0

S.Rengachari, S.Schilbach, T.Kaliyappan, J.Gouge, K.Zumer, J.Schwarz, H.Urlaub, C.Dienemann, A.Vannini, P.Cramer. Structural Basis of Snapc-Dependent Snrna Transcription Initiation By Rna Polymerase II. Nat.Struct.Mol.Biol. V. 29 1159 2022.
ISSN: ESSN 1545-9985
PubMed: 36424526
DOI: 10.1038/S41594-022-00857-W