Zinc in PDB 7zgp: Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna

The binding sites of Zinc atom in the Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna (pdb code 7zgp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna, PDB code: 7zgp:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:92.8 occ:1.00 NE2 B:HIS85 2.1 56.4 1.0 SG B:CYS67 2.3 63.6 1.0 SG B:CYS75 2.3 63.9 1.0 SG B:CYS81 2.3 79.0 1.0 CD2 B:HIS85 2.9 49.7 1.0 CB B:CYS67 3.0 48.4 1.0 CB B:CYS81 3.1 63.5 1.0 CE1 B:HIS85 3.2 57.6 1.0 CB B:CYS75 3.5 52.5 1.0 N6 E:A2 4.1 59.9 1.0 CG B:HIS85 4.1 51.4 1.0 ND1 B:HIS85 4.2 52.6 1.0 CB B:TRP70 4.3 45.0 1.0 CA B:CYS67 4.4 50.6 1.0 O B:TYR83 4.5 65.1 1.0 CA B:CYS81 4.6 65.8 1.0 N B:TRP70 4.6 50.8 1.0 CA B:CYS75 4.7 47.3 1.0 CB B:TYR83 4.8 60.4 1.0 O B:ASN78 4.8 73.1 1.0 CA B:TRP70 5.0 47.4 1.0

Zinc binding site 2 out of 2 in the Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Polymerase Module of Cpf in Complex with MPE1 and A Pre-Cleaved CYC1 Rna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn302 b:135.4 occ:1.00 NE2 B:HIS56 2.1 84.0 1.0 SG B:CYS46 2.3 102.9 1.0 SG B:CYS34 2.3 87.8 1.0 SG B:CYS52 2.3 95.8 1.0 CB B:CYS52 3.0 89.3 1.0 CE1 B:HIS56 3.0 82.9 1.0 CD2 B:HIS56 3.1 81.1 1.0 CB B:CYS46 3.5 98.1 1.0 CB B:CYS34 3.5 81.8 1.0 ND1 B:HIS56 4.1 82.3 1.0 CG B:HIS56 4.2 81.2 1.0 NE B:ARG48 4.2 98.8 1.0 CB B:TYR37 4.4 84.6 1.0 CA B:CYS52 4.5 87.2 1.0 CB B:LYS54 4.5 76.0 1.0 NH2 B:ARG48 4.5 96.4 1.0 CZ B:ARG48 4.7 98.5 1.0 CA B:CYS46 4.7 97.8 1.0 CA B:CYS34 4.7 83.4 1.0 O B:GLY49 4.8 100.1 1.0 N B:TYR37 4.8 87.0 1.0 CB B:ARG48 4.9 94.3 1.0 CD B:ARG48 5.0 96.1 1.0

J.B.Rodriguez-Molina, F.J.O'reilly, H.Fagarasan, E.Sheekey, S.Maslen, J.M.Skehel, J.Rappsilber, L.A.Passmore. MPE1 Senses the Binding of Pre-Mrna and Controls 3' End Processing By Cpf. Mol.Cell V. 82 2490 2022.
ISSN: ISSN 1097-2765
PubMed: 35584695
DOI: 10.1016/J.MOLCEL.2022.04.021