Zinc in PDB 7y38: Molecular Architecture of the Chikungunya Virus Replication Complex

All present enzymatic activity of Molecular Architecture of the Chikungunya Virus Replication Complex:
2.7.7.19; 2.7.7.48; 3.1.3.33; 3.6.1.15; 3.6.4.13;

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Zinc atom in the Molecular Architecture of the Chikungunya Virus Replication Complex (pdb code 7y38). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 12 binding sites of Zinc where determined in the Molecular Architecture of the Chikungunya Virus Replication Complex, PDB code: 7y38:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:174.8 occ:1.00 NE2 A:HIS79 2.3 108.1 1.0 SG A:CYS141 2.3 120.5 1.0 SG A:CYS134 2.3 138.7 1.0 OE1 A:GLU129 2.8 138.0 1.0 CB A:CYS134 2.8 128.3 1.0 CE1 A:HIS79 3.2 108.2 1.0 CD2 A:HIS79 3.3 108.0 1.0 CB A:CYS141 3.3 114.6 1.0 CD A:GLU129 3.9 138.7 1.0 OE2 A:GLU129 4.2 139.7 1.0 ND1 A:HIS79 4.3 109.0 1.0 CA A:CYS134 4.3 123.2 1.0 CA A:CYS141 4.3 115.2 1.0 CB A:GLN143 4.3 121.2 1.0 CG2 A:VAL81 4.3 90.8 1.0 CG A:HIS79 4.3 109.0 1.0 N A:CYS134 4.8 121.6 1.0 N A:GLN143 4.9 123.5 1.0 O A:CYS80 5.0 109.7 1.0

Zinc binding site 2 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:178.1 occ:1.00 NE2 B:HIS79 2.3 108.3 1.0 SG B:CYS141 2.3 115.0 1.0 SG B:CYS134 2.3 144.0 1.0 OE1 B:GLU129 2.7 139.1 1.0 CB B:CYS134 2.8 133.1 1.0 CE1 B:HIS79 3.1 107.6 1.0 CD B:GLU129 3.4 139.7 1.0 CD2 B:HIS79 3.4 107.6 1.0 OE2 B:GLU129 3.4 140.7 1.0 CB B:CYS141 3.7 116.0 1.0 ND1 B:HIS79 4.3 106.5 1.0 CA B:CYS134 4.3 130.6 1.0 CA B:CYS141 4.3 116.0 1.0 CG2 B:VAL81 4.3 99.9 1.0 CG B:HIS79 4.4 107.0 1.0 CB B:GLN143 4.6 117.7 1.0 CG B:GLU129 4.7 138.8 1.0 N B:ARG142 4.7 121.2 1.0 N B:CYS134 4.8 129.6 1.0 CD2 B:HIS136 4.8 124.2 1.0 N B:GLN143 4.9 118.4 1.0 O B:PHE133 4.9 129.3 1.0

Zinc binding site 3 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1001 b:181.7 occ:1.00 SG C:CYS141 2.3 120.9 1.0 SG C:CYS134 2.3 142.3 1.0 NE2 C:HIS79 2.3 109.5 1.0 CB C:CYS134 2.6 132.3 1.0 CE1 C:HIS79 2.9 108.1 1.0 OE1 C:GLU129 3.1 131.3 1.0 CB C:CYS141 3.4 118.3 1.0 CD2 C:HIS79 3.5 111.2 1.0 OE2 C:GLU129 3.6 129.9 1.0 CD C:GLU129 3.7 131.2 1.0 CA C:CYS134 4.1 128.9 1.0 CA C:CYS141 4.1 121.2 1.0 ND1 C:HIS79 4.2 106.0 1.0 O C:PHE133 4.4 121.4 1.0 CG C:HIS79 4.5 108.1 1.0 ND1 C:HIS136 4.6 126.4 1.0 CG2 C:VAL81 4.6 109.5 1.0 N C:ARG142 4.7 123.8 1.0 N C:CYS134 4.8 127.5 1.0 C C:CYS141 4.9 122.7 1.0 C C:PHE133 4.9 118.0 1.0 CB C:GLN143 4.9 120.4 1.0 OE1 C:GLN143 5.0 129.8 1.0

Zinc binding site 4 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1001 b:203.0 occ:1.00 OE2 D:GLU129 2.3 142.2 1.0 SG D:CYS141 2.3 126.4 1.0 SG D:CYS134 2.3 144.8 1.0 NE2 D:HIS79 2.3 102.8 1.0 CB D:CYS134 2.9 134.9 1.0 CE1 D:HIS79 3.0 102.3 1.0 CD D:GLU129 3.5 138.6 1.0 CD2 D:HIS79 3.5 103.2 1.0 CB D:CYS141 3.6 123.9 1.0 OE1 D:GLU129 4.2 137.9 1.0 ND1 D:HIS79 4.2 101.5 1.0 CA D:CYS134 4.3 132.1 1.0 CA D:CYS141 4.4 122.8 1.0 CB D:GLN143 4.5 119.0 1.0 CG D:HIS79 4.5 101.3 1.0 CG D:GLU129 4.5 136.2 1.0 CD2 D:HIS136 4.6 130.7 1.0 CG2 D:VAL81 4.7 92.0 1.0 N D:CYS134 4.8 130.1 1.0 N D:ARG142 4.9 122.7 1.0 O D:PHE133 5.0 125.2 1.0

Zinc binding site 5 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn1001 b:157.0 occ:1.00 NE2 E:HIS79 2.3 98.3 1.0 SG E:CYS141 2.3 117.0 1.0 SG E:CYS134 2.3 138.7 1.0 OE1 E:GLU129 2.8 133.8 1.0 CB E:CYS134 2.8 123.3 1.0 CE1 E:HIS79 3.0 96.5 1.0 CD2 E:HIS79 3.5 99.9 1.0 CD E:GLU129 3.6 134.3 1.0 CB E:CYS141 3.6 112.5 1.0 OE2 E:GLU129 3.6 135.9 1.0 ND1 E:HIS79 4.2 95.7 1.0 CG2 E:VAL81 4.3 87.9 1.0 CA E:CYS134 4.3 119.9 1.0 CA E:CYS141 4.3 114.6 1.0 CB E:GLN143 4.4 110.9 1.0 CG E:HIS79 4.5 98.0 1.0 N E:ARG142 4.7 122.0 1.0 ND1 E:HIS136 4.8 121.1 1.0 N E:CYS134 4.8 116.3 1.0 N E:GLN143 5.0 110.6 1.0 CG E:GLU129 5.0 134.6 1.0

Zinc binding site 6 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn1001 b:192.7 occ:1.00 OE2 F:GLU129 2.1 133.3 1.0 SG F:CYS141 2.3 121.3 1.0 NE2 F:HIS79 2.3 102.8 1.0 SG F:CYS134 2.3 135.3 1.0 CB F:CYS134 2.6 130.3 1.0 CE1 F:HIS79 3.1 102.5 1.0 CD F:GLU129 3.2 131.3 1.0 CD2 F:HIS79 3.4 104.0 1.0 CB F:CYS141 3.4 118.2 1.0 OE1 F:GLU129 3.6 131.4 1.0 CG2 F:VAL81 4.0 96.7 1.0 CA F:CYS134 4.1 126.4 1.0 ND1 F:HIS79 4.3 101.8 1.0 CA F:CYS141 4.3 118.7 1.0 CG F:HIS79 4.4 103.0 1.0 CG F:GLU129 4.5 128.3 1.0 ND1 F:HIS136 4.5 130.1 1.0 CB F:GLN143 4.5 117.7 1.0 N F:CYS134 4.9 125.2 1.0 C F:CYS134 4.9 126.7 1.0 N F:ARG142 4.9 123.1 1.0

Zinc binding site 7 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn1001 b:187.8 occ:1.00 NE2 G:HIS79 2.3 92.7 1.0 SG G:CYS141 2.3 104.5 1.0 SG G:CYS134 2.3 131.8 1.0 CB G:CYS134 2.5 126.6 1.0 CE1 G:HIS79 2.9 92.8 1.0 OE1 G:GLU129 3.2 128.1 1.0 CD2 G:HIS79 3.5 92.2 1.0 CB G:CYS141 3.8 105.5 1.0 CD G:GLU129 3.9 127.8 1.0 OE2 G:GLU129 3.9 126.8 1.0 CA G:CYS134 4.0 124.5 1.0 ND1 G:HIS79 4.2 91.9 1.0 CG2 G:VAL81 4.3 97.5 1.0 CG G:HIS79 4.5 91.4 1.0 CA G:CYS141 4.5 106.9 1.0 ND1 G:HIS136 4.7 126.7 1.0 CG1 G:VAL81 4.7 98.7 1.0 N G:CYS134 4.7 122.8 1.0 O G:PHE133 4.9 114.1 1.0 C G:CYS134 4.9 124.9 1.0 N G:ARG142 4.9 112.3 1.0 CB G:GLN143 4.9 104.4 1.0 CB G:VAL81 5.0 96.5 1.0

Zinc binding site 8 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn1001 b:178.3 occ:1.00 NE2 H:HIS79 2.3 101.9 1.0 SG H:CYS141 2.3 114.4 1.0 SG H:CYS134 2.3 135.0 1.0 CB H:CYS134 2.4 127.9 1.0 OE1 H:GLU129 2.9 130.9 1.0 CE1 H:HIS79 3.0 101.2 1.0 CD2 H:HIS79 3.5 103.1 1.0 CD H:GLU129 3.7 130.4 1.0 OE2 H:GLU129 3.7 129.2 1.0 CB H:CYS141 3.8 112.3 1.0 CA H:CYS134 3.9 123.9 1.0 CG2 H:VAL81 4.1 98.6 1.0 ND1 H:HIS79 4.3 99.4 1.0 CA H:CYS141 4.4 112.7 1.0 CG H:HIS79 4.5 99.0 1.0 O H:PHE133 4.5 123.5 1.0 ND1 H:HIS136 4.5 131.0 1.0 N H:CYS134 4.7 121.4 1.0 CG1 H:VAL81 4.8 101.5 1.0 C H:CYS134 4.8 123.5 1.0 CB H:GLN143 4.9 118.3 1.0 O H:CYS80 4.9 108.5 1.0 CB H:VAL81 4.9 98.7 1.0 C H:PHE133 4.9 118.2 1.0 N H:ARG142 4.9 117.9 1.0 N H:LEU135 5.0 113.8 1.0

Zinc binding site 9 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ I:Zn1001 b:221.3 occ:1.00 OE1 I:GLU129 2.3 136.2 1.0 NE2 I:HIS79 2.3 110.0 1.0 SG I:CYS141 2.3 124.6 1.0 SG I:CYS134 2.3 140.4 1.0 CB I:CYS134 2.5 136.8 1.0 CE1 I:HIS79 2.8 111.3 1.0 CD I:GLU129 3.3 135.3 1.0 CD2 I:HIS79 3.6 110.3 1.0 OE2 I:GLU129 3.7 135.4 1.0 CA I:CYS134 3.8 134.2 1.0 CB I:CYS141 3.9 123.5 1.0 ND1 I:HIS79 4.0 110.0 1.0 O I:PHE133 4.4 124.6 1.0 CB I:GLN143 4.4 121.9 1.0 CG I:HIS79 4.5 110.3 1.0 ND1 I:HIS136 4.5 131.1 1.0 CA I:CYS141 4.6 125.5 1.0 CG I:GLU129 4.6 134.8 1.0 N I:CYS134 4.7 133.1 1.0 N I:ARG142 4.8 124.9 1.0 N I:GLN143 4.8 122.4 1.0 C I:PHE133 4.8 121.9 1.0 C I:CYS134 4.9 134.4 1.0 CB I:GLU129 4.9 134.1 1.0 O I:THR130 5.0 132.0 1.0

Zinc binding site 10 out of 12 in the Molecular Architecture of the Chikungunya Virus Replication Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Molecular Architecture of the Chikungunya Virus Replication Complex within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn1001 b:166.6 occ:1.00 NE2 J:HIS79 2.3 102.9 1.0 SG J:CYS141 2.3 117.8 1.0 SG J:CYS134 2.3 124.8 1.0 CE1 J:HIS79 3.0 101.5 1.0 OE1 J:GLU129 3.0 129.5 1.0 CB J:CYS134 3.0 117.8 1.0 CD2 J:HIS79 3.5 102.0 1.0 CB J:CYS141 3.7 117.2 1.0 CD J:GLU129 3.8 129.7 1.0 OE2 J:GLU129 3.9 130.1 1.0 ND1 J:HIS79 4.2 101.2 1.0 CG2 J:VAL81 4.3 91.9 1.0 CG J:HIS79 4.5 101.4 1.0 CA J:CYS134 4.5 116.1 1.0 CA J:CYS141 4.5 116.9 1.0 ND1 J:HIS136 4.6 118.0 1.0 CB J:GLN143 4.7 111.9 1.0 O J:CYS80 4.7 107.5 1.0 N J:CYS134 4.9 114.5 1.0

Y.B.Tan, D.Chmielewski, M.C.Y.Law, K.Zhang, Y.He, M.Chen, J.Jin, D.Luo. Molecular Architecture of the Chikungunya Virus Replication Complex. Sci Adv V. 8 D2536 2022.
ISSN: ESSN 2375-2548
PubMed: 36449616
DOI: 10.1126/SCIADV.ADD2536