Zinc in PDB 7y0i: Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide

All present enzymatic activity of Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide:
2.1.1.359; 2.1.1.367;

The binding sites of Zinc atom in the Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide (pdb code 7y0i). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide, PDB code: 7y0i:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:0.0 occ:1.00 ND1 A:HIS31 2.1 0.0 1.0 SG A:CYS34 2.3 0.0 1.0 SG A:CYS11 2.3 0.0 1.0 SG A:CYS9 2.3 0.0 1.0 HB2 A:HIS31 2.7 0.0 1.0 CE1 A:HIS31 3.1 0.0 1.0 CG A:HIS31 3.1 0.0 1.0 HB2 A:CYS11 3.2 0.0 1.0 HE1 A:HIS31 3.3 0.0 1.0 H A:HIS31 3.3 0.0 1.0 H A:CYS11 3.4 0.0 1.0 CB A:CYS34 3.4 0.0 1.0 HB2 A:CYS34 3.4 0.0 1.0 HB3 A:CYS9 3.4 0.0 1.0 CB A:HIS31 3.4 0.0 1.0 CB A:CYS11 3.4 0.0 1.0 CB A:CYS9 3.4 0.0 1.0 HB3 A:CYS34 3.5 0.0 1.0 HB2 A:CYS9 3.7 0.0 1.0 N A:CYS11 4.1 0.0 1.0 N A:HIS31 4.1 0.0 1.0 HG12 A:ILE10 4.2 0.0 1.0 NE2 A:HIS31 4.2 0.0 1.0 HB3 A:HIS31 4.2 0.0 1.0 HB3 A:CYS11 4.2 0.0 1.0 CD2 A:HIS31 4.2 0.0 1.0 CA A:CYS11 4.3 0.0 1.0 CA A:HIS31 4.3 0.0 1.0 H A:CYS34 4.3 0.0 1.0 HG13 A:ILE10 4.4 0.0 1.0 O A:HIS31 4.5 0.0 1.0 HA A:CYS11 4.6 0.0 1.0 H A:ILE10 4.7 0.0 1.0 CA A:CYS34 4.8 0.0 1.0 CG1 A:ILE10 4.8 0.0 1.0 CA A:CYS9 4.8 0.0 1.0 SD A:MET35 4.8 0.0 1.0 C A:HIS31 4.9 0.0 1.0 OD2 A:ASP33 4.9 0.0 1.0 N A:ILE10 4.9 0.0 1.0 N A:CYS34 4.9 0.0 1.0

Zinc binding site 2 out of 2 in the Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structures of ASH1L Phd Domain in Complex with H3K4ME2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:0.0 occ:1.00 SG A:CYS23 2.3 0.0 1.0 SG A:CYS49 2.3 0.0 1.0 SG A:CYS46 2.3 0.0 1.0 SG A:CYS26 2.3 0.0 1.0 H A:CYS26 3.0 0.0 1.0 H A:CYS46 3.1 0.0 1.0 HB2 A:CYS49 3.1 0.0 1.0 HB3 A:CYS46 3.3 0.0 1.0 HB3 A:CYS23 3.3 0.0 1.0 HB3 A:CYS26 3.3 0.0 1.0 CB A:CYS23 3.4 0.0 1.0 CB A:CYS49 3.4 0.0 1.0 CB A:CYS46 3.4 0.0 1.0 CB A:CYS26 3.4 0.0 1.0 H A:CYS49 3.5 0.0 1.0 HB2 A:LYS25 3.5 0.0 1.0 HB2 A:CYS23 3.7 0.0 1.0 HG23 A:VAL28 3.8 0.0 1.0 HB2 A:GLN48 3.8 0.0 1.0 N A:CYS26 3.8 0.0 1.0 N A:CYS46 3.9 0.0 1.0 N A:CYS49 4.1 0.0 1.0 HD21 A:LEU45 4.1 0.0 1.0 HB3 A:CYS49 4.2 0.0 1.0 CA A:CYS46 4.2 0.0 1.0 CA A:CYS26 4.3 0.0 1.0 H A:LYS25 4.3 0.0 1.0 HB2 A:CYS46 4.3 0.0 1.0 HB2 A:CYS26 4.3 0.0 1.0 CA A:CYS49 4.3 0.0 1.0 HB3 A:LYS25 4.4 0.0 1.0 HG21 A:VAL28 4.4 0.0 1.0 CB A:LYS25 4.4 0.0 1.0 HD22 A:LEU45 4.4 0.0 1.0 HA A:LEU45 4.5 0.0 1.0 CG2 A:VAL28 4.6 0.0 1.0 O A:CYS46 4.6 0.0 1.0 H A:GLN48 4.7 0.0 1.0 C A:CYS46 4.7 0.0 1.0 HE A:ARG8 4.7 0.0 1.0 H A:MET27 4.7 0.0 1.0 CA A:CYS23 4.8 0.0 1.0 HG12 A:VAL28 4.8 0.0 1.0 CD2 A:LEU45 4.8 0.0 1.0 CB A:GLN48 4.8 0.0 1.0 HA A:CYS49 4.8 0.0 1.0 C A:LYS25 4.9 0.0 1.0 HB3 A:LEU45 4.9 0.0 1.0 N A:LYS25 4.9 0.0 1.0 C A:LEU45 5.0 0.0 1.0 H A:VAL28 5.0 0.0 1.0

M.Yu, Y.Jia, Z.Ma, D.Ji, C.Wang, Y.Liang, Q.Zhang, H.Yi, L.Zeng. Structural Insight Into ASH1L Phd Finger Recognizing Methylated Histone H3K4 and Promoting Cell Growth in Prostate Cancer. Front Oncol V. 12 06807 2022.
ISSN: ISSN 2234-943X
PubMed: 36033518
DOI: 10.3389/FONC.2022.906807