Zinc in PDB 7xaz: Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2

All present enzymatic activity of Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2:
3.4.17.23;

The structure of Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2, PDB code: 7xaz was solved by H.Liao, Y.Meng, W.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.59 / 3.00
Space group	P 41
Cell size a, b, c (Å), α, β, γ (°)	129.52, 129.52, 189.199, 90, 90, 90
R / Rfree (%)	19.8 / 23

The binding sites of Zinc atom in the Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2 (pdb code 7xaz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2, PDB code: 7xaz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn704 b:46.4 occ:1.00 OE2 A:GLU402 2.0 43.5 1.0 NE2 A:HIS374 2.1 35.6 1.0 NE2 A:HIS378 2.1 43.6 1.0 CD A:GLU402 2.8 55.0 1.0 CD2 A:HIS378 2.9 35.5 1.0 OE1 A:GLU402 3.0 56.4 1.0 CE1 A:HIS374 3.0 31.4 1.0 CD2 A:HIS374 3.1 32.3 1.0 CE1 A:HIS378 3.2 39.8 1.0 OE2 A:GLU375 3.6 49.7 1.0 CG A:HIS378 4.1 29.4 1.0 ND1 A:HIS374 4.2 36.7 1.0 ND1 A:HIS378 4.2 33.8 1.0 CG A:GLU402 4.2 42.0 1.0 CD A:GLU375 4.2 51.6 1.0 CG A:HIS374 4.2 36.4 1.0 OE1 A:GLU375 4.3 51.4 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Omicron Ba.1.1 Rbd Complexed with HACE2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn703 b:60.1 occ:1.00 OE2 C:GLU402 2.0 72.6 1.0 NE2 C:HIS374 2.1 41.5 1.0 NE2 C:HIS378 2.1 51.5 1.0 CD C:GLU402 2.9 67.0 1.0 CD2 C:HIS378 2.9 42.6 1.0 CD2 C:HIS374 3.0 40.7 1.0 CE1 C:HIS378 3.1 50.8 1.0 OE1 C:GLU402 3.1 66.9 1.0 CE1 C:HIS374 3.2 51.6 1.0 OE2 C:GLU375 3.8 54.5 1.0 CG C:HIS378 4.0 33.9 1.0 ND1 C:HIS378 4.1 41.8 1.0 CG C:HIS374 4.2 48.1 1.0 CG C:GLU402 4.2 47.5 1.0 ND1 C:HIS374 4.2 52.8 1.0 CD C:GLU375 4.5 54.6 1.0 OE1 C:GLU375 4.7 53.4 1.0

L.Li, H.Liao, Y.Meng, W.Li, P.Han, K.Liu, Q.Wang, D.Li, Y.Zhang, L.Wang, Z.Fan, Y.Zhang, Q.Wang, X.Zhao, Y.Sun, N.Huang, J.Qi, G.F.Gao. Structural Basis of Human ACE2 Higher Binding Affinity to Currently Circulating Omicron Sars-Cov-2 Sub-Variants Ba.2 and Ba.1.1. Cell V. 185 2952 2022.
ISSN: ISSN 1097-4172
PubMed: 35809570
DOI: 10.1016/J.CELL.2022.06.023