Zinc in PDB 7w9u: Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase

Enzymatic activity of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase

All present enzymatic activity of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase:
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase, PDB code: 7w9u was solved by A.A.Momin, A.S.Sandholu, S.T.Arold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.20 / 2.16
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 49.2, 52.45, 53.37, 90.02, 90, 90
R / Rfree (%) 21.5 / 27.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase (pdb code 7w9u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase, PDB code: 7w9u:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in 7w9u

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Zinc binding site 1 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1101

b:44.3
occ:1.00
 ND1 A:HIS1055 2.1 82.6 1.0
CE1 A:HIS1055 2.2 78.3 1.0
CG A:HIS1055 2.8 92.8 1.0
NE2 A:HIS1055 2.8 85.2 1.0
CD2 A:HIS1055 3.2 92.6 1.0
CB A:HIS1055 3.8 106.3 1.0

Zinc binding site 2 out of 8 in 7w9u

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Zinc binding site 2 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1102

b:39.5
occ:1.00
 O A:HOH1212 1.8 52.7 1.0
OE1 A:GLU940 2.0 37.0 1.0
OE2 A:GLU959 2.1 42.4 1.0
OE1 A:GLU959 2.6 40.6 1.0
CD A:GLU959 2.7 38.2 1.0
CD A:GLU940 2.9 38.6 1.0
OE2 A:GLU940 3.2 51.8 1.0
NZ A:LYS936 3.7 50.0 1.0
CG A:GLU959 4.2 39.7 1.0
CG A:GLU940 4.3 37.9 1.0
CD A:LYS936 4.4 64.1 1.0
CE A:LYS936 4.6 49.2 1.0
CA A:ALA937 4.7 28.5 1.0
CB A:GLU940 4.8 33.7 1.0
CB A:ALA937 4.8 27.7 1.0

Zinc binding site 3 out of 8 in 7w9u

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Zinc binding site 3 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1101

b:42.1
occ:1.00
 NE2 B:HIS1055 1.8 52.8 1.0
OD2 D:ASP1042 2.1 34.0 1.0
O D:HOH1207 2.2 31.1 1.0
CE1 B:HIS1055 2.7 64.8 1.0
CG D:ASP1042 2.7 33.1 1.0
CD2 B:HIS1055 2.8 72.5 1.0
OD1 D:ASP1042 2.8 29.0 1.0
ND1 B:HIS1055 3.7 86.7 1.0
CG B:HIS1055 3.8 97.6 1.0
NE2 D:GLN1043 4.1 57.7 1.0
CB D:ASP1042 4.2 33.5 1.0
O D:ASP1042 4.3 33.2 1.0
C D:ASP1042 4.5 33.4 1.0
CA D:ASP1042 4.9 34.3 1.0

Zinc binding site 4 out of 8 in 7w9u

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Zinc binding site 4 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1101

b:45.6
occ:1.00
 NE2 C:HIS1055 1.9 77.0 1.0
CD2 C:HIS1055 2.4 79.3 1.0
CE1 C:HIS1055 2.8 81.3 1.0
CG C:HIS1055 3.3 90.7 1.0
ND1 C:HIS1055 3.5 88.2 1.0
CB C:HIS1055 4.6 102.5 1.0

Zinc binding site 5 out of 8 in 7w9u

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Zinc binding site 5 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1102

b:36.4
occ:1.00
 O C:HOH1205 2.0 38.1 1.0
ND1 C:HIS983 2.1 26.4 1.0
CG C:HIS983 3.0 27.8 1.0
CB C:HIS983 3.2 24.3 1.0
CE1 C:HIS983 3.2 26.9 1.0
CD2 C:HIS983 4.2 24.3 1.0
NE2 C:HIS983 4.3 28.6 1.0
OE2 C:GLU987 4.4 70.0 1.0
CA C:HIS983 4.7 32.0 1.0
CG2 C:ILE975 4.8 32.9 1.0
O C:ALA980 4.9 37.6 1.0

Zinc binding site 6 out of 8 in 7w9u

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Zinc binding site 6 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn1103

b:38.0
occ:1.00
 O B:HOH1208 1.9 40.0 1.0
ND1 B:HIS983 2.0 32.1 1.0
OE2 C:GLU959 2.0 39.7 1.0
OE1 C:GLU940 2.1 35.6 1.0
CD C:GLU959 2.8 40.4 1.0
OE2 C:GLU940 2.8 40.5 1.0
CD C:GLU940 2.8 34.2 1.0
CE1 B:HIS983 2.9 35.0 1.0
CG B:HIS983 3.0 34.9 1.0
OE1 C:GLU959 3.0 43.9 1.0
CB B:HIS983 3.3 31.8 1.0
NE2 B:HIS983 4.1 38.6 1.0
CD2 B:HIS983 4.1 35.2 1.0
CG C:GLU959 4.2 37.9 1.0
O C:HOH1210 4.2 51.4 1.0
CG C:GLU940 4.3 34.6 1.0
O C:HOH1207 4.3 47.5 1.0
OE2 B:GLU987 4.4 58.9 1.0
CG2 B:ILE975 4.7 34.8 1.0
CA C:ALA937 4.8 34.9 1.0
CB C:GLU940 4.8 35.6 1.0
CB C:ALA937 4.8 30.9 1.0
CA B:HIS983 4.8 34.9 1.0
CE C:LYS936 4.9 46.1 1.0

Zinc binding site 7 out of 8 in 7w9u

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Zinc binding site 7 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1101

b:43.5
occ:1.00
 ND1 D:HIS1028 2.0 39.3 1.0
OD2 B:ASP1042 2.1 41.9 1.0
O B:HOH1209 2.3 31.4 1.0
CG B:ASP1042 2.8 38.9 1.0
OD1 B:ASP1042 2.8 40.5 1.0
CG D:HIS1028 3.0 38.2 1.0
CE1 D:HIS1028 3.0 35.0 1.0
CB D:HIS1028 3.3 35.5 1.0
CD2 D:HIS1028 4.1 35.1 1.0
NE2 D:HIS1028 4.1 33.8 1.0
CB B:ASP1042 4.3 36.4 1.0
O B:ASP1042 4.3 38.3 1.0
NE2 B:GLN1043 4.3 66.7 1.0
C B:ASP1042 4.6 37.5 1.0
O D:LEU1024 4.8 44.7 1.0
CA D:HIS1028 4.8 34.5 1.0
CA B:ASP1042 5.0 39.1 1.0

Zinc binding site 8 out of 8 in 7w9u

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Zinc binding site 8 out of 8 in the Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1102

b:39.8
occ:1.00
 OE2 D:GLU959 1.9 40.9 1.0
OE1 D:GLU940 1.9 43.1 1.0
O D:HOH1206 2.0 41.1 1.0
CD D:GLU940 2.6 39.7 1.0
OE2 D:GLU940 2.6 51.4 1.0
CD D:GLU959 2.7 36.9 1.0
OE1 D:GLU959 2.8 36.0 1.0
CG D:GLU940 4.1 37.5 1.0
CG D:GLU959 4.1 37.1 1.0
O D:HOH1213 4.2 40.1 1.0
NZ D:LYS936 4.5 63.9 1.0
CB D:GLU940 4.7 35.6 1.0
CA D:ALA937 4.7 33.1 1.0
O D:HOH1212 4.9 38.7 1.0
CB D:ALA937 4.9 32.8 1.0

Reference:

A.A.Momin, A.S.Sandholu, S.T.Arold. Crystal Structure of Zn Bound Human Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase To Be Published.
Page generated: Wed Oct 30 13:42:42 2024

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