Zinc in PDB 7w67: The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide

Enzymatic activity of The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide

All present enzymatic activity of The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide:
2.1.1.364;

Protein crystallography data

The structure of The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide, PDB code: 7w67 was solved by L.Zhao, Y.Li, Y.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 31.89 / 2.19
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 76.15, 44.571, 121.333, 90, 108.92, 90
R / Rfree (%) 17.5 / 22.2

Zinc Binding Sites:

The binding sites of Zinc atom in the The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide (pdb code 7w67). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide, PDB code: 7w67:

Zinc binding site 1 out of 1 in 7w67

Go back to Zinc Binding Sites List in 7w67
Zinc binding site 1 out of 1 in the The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in Complex with H3K4ME0 Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn4002

b:63.6
occ:1.00
 SG C:CYS3958 2.2 60.5 1.0
SG C:CYS3960 2.3 56.4 1.0
SG C:CYS3910 2.4 58.4 1.0
SG C:CYS3965 2.6 62.7 1.0
CB C:CYS3958 3.1 62.0 1.0
CB C:CYS3960 3.4 46.2 1.0
CB C:CYS3965 3.4 65.2 1.0
CB C:CYS3910 3.5 62.6 1.0
CA C:CYS3965 3.8 69.4 1.0
N C:CYS3910 3.9 53.5 1.0
N C:CYS3960 4.0 59.0 1.0
N C:ARG3966 4.1 71.2 1.0
CA C:CYS3960 4.3 59.4 1.0
CA C:CYS3910 4.4 53.3 1.0
C C:CYS3965 4.4 70.0 1.0
CA C:CYS3958 4.4 64.9 1.0
N C:LYS3967 4.5 69.9 1.0
C C:CYS3958 4.5 66.8 1.0
NE2 C:HIS3908 4.6 55.5 1.0
CD2 C:HIS3908 4.6 50.9 1.0
O C:CYS3958 4.7 66.6 1.0
C C:SER3909 4.8 51.7 1.0
N C:ASN3959 5.0 64.9 1.0
N C:GLY3961 5.0 57.5 1.0
C C:CYS3960 5.0 61.0 1.0

Reference:

Y.Li, L.Zhao, Y.Zhang, P.Wu, Y.Xu, J.Mencius, Y.Zheng, X.Wang, W.Xu, N.Huang, X.Ye, M.Lei, P.Shi, C.Tian, C.Peng, G.Li, Z.Liu, S.Quan, Y.Chen. Structural Basis For Product Specificities of Mll Family Methyltransferases. Mol.Cell V. 82 3810 2022.
ISSN: ISSN 1097-2765
PubMed: 36108631
DOI: 10.1016/J.MOLCEL.2022.08.022
Page generated: Sat Apr 8 05:08:44 2023

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