Zinc in PDB 7uo4: Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State:
2.7.7.48;

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State (pdb code 7uo4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State, PDB code: 7uo4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1003 b:30.4 occ:1.00 O A:HOH1160 1.9 16.4 1.0 ND1 A:HIS295 2.2 7.8 1.0 SG A:CYS310 2.3 8.4 1.0 SG A:CYS301 2.3 11.3 1.0 SG A:CYS306 2.3 12.0 1.0 CG A:HIS295 3.1 7.8 1.0 O A:HOH1166 3.2 11.6 1.0 CB A:HIS295 3.2 7.8 1.0 CE1 A:HIS295 3.3 7.8 1.0 CB A:CYS301 3.6 11.3 1.0 CA A:CYS301 3.7 11.3 1.0 CB A:CYS310 3.9 8.4 1.0 N A:HIS295 3.9 7.8 1.0 O A:CYS306 4.0 12.0 1.0 CB A:CYS306 4.1 12.0 1.0 CA A:HIS295 4.2 7.8 1.0 CD2 A:HIS295 4.2 7.8 1.0 NE2 A:HIS295 4.3 7.8 1.0 N A:CYS301 4.5 11.3 1.0 C A:CYS306 4.6 12.0 1.0 O A:HIS295 4.6 7.8 1.0 O A:ASN300 4.7 8.0 1.0 O A:THR293 4.8 8.0 1.0 C A:CYS301 4.8 11.3 1.0 CA A:CYS306 4.9 12.0 1.0 N A:LEU302 4.9 16.4 1.0 C A:HIS295 4.9 7.8 1.0 C A:ASN300 4.9 8.0 1.0 C A:TYR294 5.0 6.6 1.0

Zinc binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1004 b:52.4 occ:1.00 ND1 A:HIS642 2.0 14.0 1.0 SG A:CYS487 2.3 15.6 1.0 SG A:CYS646 2.3 10.6 1.0 SG A:CYS645 2.3 17.9 1.0 CG A:HIS642 2.5 14.0 1.0 CB A:HIS642 2.7 14.0 1.0 CE1 A:HIS642 3.0 14.0 1.0 CE1 A:PHE571 3.4 9.7 1.0 CB A:CYS646 3.5 10.6 1.0 CD2 A:HIS642 3.5 14.0 1.0 NE2 A:HIS642 3.8 14.0 1.0 CB A:CYS487 3.8 15.6 1.0 CD1 A:PHE571 4.0 9.7 1.0 CA A:HIS642 4.0 14.0 1.0 N A:CYS487 4.0 15.6 1.0 CB A:CYS645 4.1 17.9 1.0 CZ A:PHE571 4.1 9.7 1.0 N A:CYS646 4.2 10.6 1.0 CA A:CYS487 4.4 15.6 1.0 CA A:CYS646 4.5 10.6 1.0 C A:GLY486 4.7 13.2 1.0 C A:CYS645 4.8 17.9 1.0 C A:HIS642 4.9 14.0 1.0 O A:HIS642 5.0 14.0 1.0 N A:HIS642 5.0 14.0 1.0

B.F.Malone, S.A.Darst. Sars-Cov-2 Replication-Transcription Complex Bound to Remdesivir Triphosphate, in A Pre-Catalytic State To Be Published.