Zinc in PDB 7sn8: Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6

The binding sites of Zinc atom in the Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6 (pdb code 7sn8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6, PDB code: 7sn8:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6 within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn800 b:64.0 occ:1.00 ND1 K:HIS70 2.3 47.6 1.0 NE2 K:HIS68 2.3 47.6 1.0 NE2 K:HIS157 2.3 47.6 1.0 CD2 K:HIS68 3.0 47.6 1.0 OD2 K:ASP178 3.1 47.6 1.0 CE1 K:HIS157 3.1 47.6 1.0 CE1 K:HIS70 3.2 47.6 1.0 CG K:HIS70 3.3 47.6 1.0 CD2 K:HIS157 3.4 47.6 1.0 CE1 K:HIS68 3.5 47.6 1.0 CB K:HIS70 3.6 47.6 1.0 CG K:ASP178 3.9 47.6 1.0 CB K:ASP178 3.9 47.6 1.0 ZN K:ZN801 4.2 79.3 1.0 CG K:HIS68 4.2 47.6 1.0 ND1 K:HIS157 4.3 47.6 1.0 NE2 K:HIS70 4.4 47.6 1.0 CD2 K:HIS70 4.4 47.6 1.0 ND1 K:HIS68 4.4 47.6 1.0 CG K:HIS157 4.5 47.6 1.0 CD2 K:HIS73 4.5 44.0 1.0 NE2 K:HIS73 4.6 44.0 1.0 OD1 K:ASP72 4.6 44.3 1.0 NE2 K:HIS392 4.7 48.4 1.0 CG1 K:VAL158 4.9 47.6 1.0 OD2 K:ASP72 4.9 44.3 1.0 CA K:HIS70 5.0 47.6 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Drosophila Integrator Cleavage Module (INTS4- INTS9-INTS11) in Complex with IP6 within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn801 b:79.3 occ:1.00 CE1 K:HIS414 2.3 48.3 1.0 NE2 K:HIS73 2.3 44.0 1.0 NE2 K:HIS414 2.3 48.3 1.0 OD2 K:ASP178 2.5 47.6 1.0 OD2 K:ASP72 2.8 44.3 1.0 CD2 K:HIS73 3.1 44.0 1.0 ND1 K:HIS414 3.4 48.3 1.0 CE1 K:HIS73 3.4 44.0 1.0 CD2 K:HIS414 3.4 48.3 1.0 CG K:ASP178 3.5 47.6 1.0 CG K:ASP72 3.7 44.3 1.0 OD1 K:ASP178 3.9 47.6 1.0 CG K:HIS414 3.9 48.3 1.0 OD1 K:ASP72 4.2 44.3 1.0 ZN K:ZN800 4.2 64.0 1.0 CG K:HIS73 4.4 44.0 1.0 ND1 K:HIS73 4.4 44.0 1.0 NE2 K:HIS392 4.5 48.4 1.0 CB K:ASP72 4.6 44.3 1.0 CB K:ASP178 4.8 47.6 1.0 NE2 K:HIS68 4.8 47.6 1.0 CE1 K:HIS68 4.9 47.6 1.0

M.H.Lin, M.K.Jensen, N.D.Elrod, K.L.Huang, K.A.Welle, E.J.Wagner, L.Tong. Inositol Hexakisphosphate Is Required For Integrator Function. Nat Commun V. 13 5742 2022.
ISSN: ESSN 2041-1723
PubMed: 36180473
DOI: 10.1038/S41467-022-33506-3