Zinc in PDB 7sn0: Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2

Enzymatic activity of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2

All present enzymatic activity of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2:
3.4.17.23;

Protein crystallography data

The structure of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2, PDB code: 7sn0 was solved by J.Pan, J.Abraham, S.Clark, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 111.96 / 3.08
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 85.709, 104.015, 223.911, 90, 90, 90
R / Rfree (%) 23.5 / 28.6

Other elements in 7sn0:

The structure of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2 (pdb code 7sn0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2, PDB code: 7sn0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7sn0

Go back to Zinc Binding Sites List in 7sn0
Zinc binding site 1 out of 2 in the Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn901

b:72.6
occ:1.00
 OE1 A:GLU402 1.9 89.0 1.0
NE2 A:HIS374 2.1 80.7 1.0
NE2 A:HIS378 2.4 85.7 1.0
CD A:GLU402 2.5 89.5 1.0
OE2 A:GLU402 2.5 92.4 1.0
CD2 A:HIS374 2.9 79.6 1.0
CD2 A:HIS378 3.1 84.6 1.0
CE1 A:HIS374 3.3 80.4 1.0
CE1 A:HIS378 3.5 85.8 1.0
OE2 A:GLU375 3.5 103.3 1.0
CG A:GLU402 4.0 85.4 1.0
CG A:HIS374 4.2 78.9 1.0
CD A:GLU375 4.3 100.4 1.0
ND1 A:HIS374 4.3 79.7 1.0
CG A:HIS378 4.4 83.6 1.0
OE1 A:GLU375 4.4 102.3 1.0
ND1 A:HIS378 4.5 85.3 1.0

Zinc binding site 2 out of 2 in 7sn0

Go back to Zinc Binding Sites List in 7sn0
Zinc binding site 2 out of 2 in the Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Spike Protein Receptor Binding Domain of Escape Mutant Sars-Cov-2 From Immunocompromised Patient (D146*) in Complex with Human Receptor ACE2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn901

b:108.7
occ:1.00
 NE2 B:HIS374 2.0 92.0 1.0
OE1 B:GLU402 2.1 96.5 1.0
NE2 B:HIS378 2.4 84.0 1.0
OE2 B:GLU402 2.7 99.2 1.0
CD B:GLU402 2.7 96.9 1.0
CD2 B:HIS374 2.7 90.8 1.0
CD2 B:HIS378 3.1 82.4 1.0
CE1 B:HIS374 3.2 92.5 1.0
OE2 B:GLU375 3.3 105.6 1.0
CE1 B:HIS378 3.6 84.2 1.0
CG B:HIS374 4.0 90.0 1.0
CD B:GLU375 4.1 102.1 1.0
CG B:GLU402 4.2 92.0 1.0
ND1 B:HIS374 4.2 92.1 1.0
OE1 B:GLU375 4.2 103.7 1.0
CG B:HIS378 4.3 80.8 1.0
ND1 B:HIS378 4.6 83.2 1.0

Reference:

K.G.Nabel, S.Shankar, J.Pan, L.E.Clark, P.Yang, A.Coscia, L.G.A.Mckay, H.H.Varnum, V.Brusic, N.V.Tolan, G.Zhou, M.Desjardins, S.E.Turbett, S.Kanjilal, A.C.Sherman, A.Dighe, R.C.Larocque, E.T.Ryan, C.Tylek, J.F.Cohen-Solal, A.T.Darcy, D.Tavella, A.Clabbers, Y.Fan, A.Griffiths, I.R.Correia, J.Seagal, L.R.Baden, R.C.Charles, J.Abraham. Structural Basis For Continued Antibody Evasion By the Sars-Cov-2 Receptor Binding Domain Science 2021.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABL6251
Page generated: Wed Oct 30 11:15:00 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy