Zinc in PDB 7s3z: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine

Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine

All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine, PDB code: 7s3z was solved by H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.19 / 1.73
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.173, 111.893, 164.775, 90, 90, 90
R / Rfree (%) 19.6 / 23.5

Other elements in 7s3z:

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine also contains other interesting chemical elements:

Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine (pdb code 7s3z). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine, PDB code: 7s3z:

Zinc binding site 1 out of 1 in 7s3z

Go back to Zinc Binding Sites List in 7s3z
Zinc binding site 1 out of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N2-((3-((2-Aminoquinolin-7-Yl)Methoxy)Phenoxy)Methyl)Pyridine-2, 6-Diamine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn805

b:41.1
occ:1.00
 SG B:CYS331 2.4 44.9 1.0
SG A:CYS326 2.4 46.1 1.0
SG A:CYS331 2.4 44.5 1.0
SG B:CYS326 2.4 41.4 1.0
CB A:CYS331 3.2 43.7 1.0
CB B:CYS331 3.3 43.9 1.0
CB B:CYS326 3.4 35.6 1.0
CB A:CYS326 3.4 36.9 1.0
CA B:CYS331 3.6 47.7 1.0
CA A:CYS331 3.6 53.5 1.0
N A:MET332 4.0 44.1 1.0
N B:MET332 4.1 37.9 1.0
N A:GLY333 4.2 47.5 1.0
C A:CYS331 4.2 53.5 1.0
N B:GLY333 4.2 38.8 1.0
C B:CYS331 4.3 43.2 1.0
CA B:GLY333 4.6 39.3 1.0
CA A:GLY333 4.6 46.5 1.0
CA B:CYS326 4.8 55.2 1.0
CA A:CYS326 4.8 54.4 1.0
O B:HOH1106 4.9 44.2 1.0
N B:CYS331 4.9 45.2 1.0
N A:CYS331 4.9 48.6 1.0
C A:MET332 5.0 44.5 1.0

Reference:

M.C.Lewis, P.M.Weerawarna, H.Li, V.Murarka, R.B.Silverman, T.L.Poulos. Selective Anti-Mrsa Inhibitors Targeting Bacterial Nitric Oxide Synthase To Be Published.
Page generated: Wed Oct 30 10:37:03 2024

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