Zinc in PDB 7s1t: Structure of the Human POT1-TPP1 Complex

The structure of Structure of the Human POT1-TPP1 Complex, PDB code: 7s1t was solved by T.Aramburu, E.Skordalakes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.44 / 2.90
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	70.88, 70.98, 103.79, 76.76, 84.61, 70.55
R / Rfree (%)	25 / 30.7

The binding sites of Zinc atom in the Structure of the Human POT1-TPP1 Complex (pdb code 7s1t). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Human POT1-TPP1 Complex, PDB code: 7s1t:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Human POT1-TPP1 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Human POT1-TPP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:61.6 occ:1.00 SG A:CYS506 2.3 72.6 1.0 SG A:CYS385 2.3 81.9 1.0 SG A:CYS382 2.4 39.3 1.0 SG A:CYS503 2.4 71.8 1.0 CB A:CYS385 3.2 64.1 1.0 CB A:CYS506 3.3 61.5 1.0 CB A:CYS503 3.3 59.4 1.0 CB A:CYS382 3.6 54.5 1.0 N A:CYS385 3.9 60.7 1.0 N A:CYS506 4.0 64.6 1.0 CA A:CYS385 4.1 58.8 1.0 CA A:CYS506 4.2 60.6 1.0 C A:GLN505 4.7 63.4 1.0 CB A:GLN505 4.7 73.1 1.0 CA A:CYS503 4.8 51.0 1.0 CB A:LEU387 4.8 59.0 1.0 C A:CYS385 4.8 56.1 1.0 CD2 A:LEU387 4.9 61.8 1.0 CA A:CYS382 4.9 48.0 1.0

Zinc binding site 2 out of 4 in the Structure of the Human POT1-TPP1 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Human POT1-TPP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn701 b:69.3 occ:1.00 SG D:CYS382 2.4 60.5 1.0 SG D:CYS385 2.4 89.1 1.0 SG D:CYS503 2.5 75.1 1.0 SG D:CYS506 2.5 73.9 1.0 CB D:CYS506 2.9 62.6 1.0 CB D:CYS385 3.1 70.3 1.0 CB D:CYS503 3.4 60.9 1.0 N D:CYS385 3.5 76.7 1.0 CB D:CYS382 3.6 66.4 1.0 CA D:CYS385 3.9 73.8 1.0 N D:CYS506 3.9 74.4 1.0 CA D:CYS506 4.0 64.9 1.0 CB D:LYS384 4.4 68.5 1.0 C D:LYS384 4.6 77.1 1.0 CG1 D:VAL536 4.6 46.4 1.0 CB D:GLN505 4.7 66.6 1.0 C D:CYS385 4.8 74.8 1.0 C D:GLN505 4.8 69.8 1.0 CA D:CYS503 4.8 48.8 1.0 CA D:LYS384 4.8 71.5 1.0 N D:LYS384 4.9 70.5 1.0 CA D:CYS382 4.9 59.6 1.0 CG D:LYS384 5.0 75.3 1.0

Zinc binding site 3 out of 4 in the Structure of the Human POT1-TPP1 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Human POT1-TPP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn701 b:72.5 occ:1.00 SG G:CYS382 2.3 87.7 1.0 SG G:CYS506 2.3 67.3 1.0 SG G:CYS385 2.3 88.0 1.0 SG G:CYS503 2.4 91.8 1.0 CB G:CYS506 2.9 64.1 1.0 CB G:CYS503 3.3 61.3 1.0 CB G:CYS382 3.3 57.7 1.0 CB G:CYS385 3.4 75.1 1.0 N G:CYS385 3.4 76.5 1.0 CA G:CYS385 4.0 74.4 1.0 N G:CYS506 4.0 67.9 1.0 CA G:CYS506 4.1 58.0 1.0 CB G:LYS384 4.1 62.6 1.0 C G:LYS384 4.4 78.1 1.0 N G:LYS384 4.6 68.2 1.0 CA G:LYS384 4.6 70.3 1.0 CA G:CYS382 4.7 63.6 1.0 CA G:CYS503 4.7 52.0 1.0 C G:CYS385 4.8 74.2 1.0 N G:HIS386 4.9 67.0 1.0 CG1 G:VAL536 5.0 55.4 1.0

Zinc binding site 4 out of 4 in the Structure of the Human POT1-TPP1 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Human POT1-TPP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn701 b:69.7 occ:1.00 SG J:CYS506 2.3 75.1 1.0 SG J:CYS385 2.3 93.0 1.0 SG J:CYS382 2.3 49.1 1.0 SG J:CYS503 2.6 89.4 1.0 CB J:CYS506 3.0 44.2 1.0 CB J:CYS385 3.1 68.1 1.0 CB J:CYS382 3.4 62.3 1.0 N J:CYS385 3.5 71.4 1.0 CB J:CYS503 3.5 59.1 1.0 CA J:CYS385 3.9 64.9 1.0 N J:CYS506 4.1 66.3 1.0 CA J:CYS506 4.2 58.1 1.0 CB J:LYS384 4.4 61.5 1.0 C J:CYS385 4.6 65.9 1.0 C J:LYS384 4.6 69.8 1.0 CA J:CYS382 4.8 61.2 1.0 CB J:LEU387 4.9 65.2 1.0 CA J:LYS384 4.9 67.1 1.0 N J:LYS384 4.9 70.7 1.0 CA J:CYS503 5.0 51.1 1.0

T.Aramburu, J.Kelich, C.Rice, E.Skordalakes. POT1-TPP1 Binding Stabilizes POT1, Promoting Efficient Telomere Maintenance. Comput Struct Biotechnol J V. 20 675 2022.
ISSN: ESSN 2001-0370
PubMed: 35140887
DOI: 10.1016/J.CSBJ.2022.01.005