Zinc in PDB 7s1o: Structure of Human POT1C

The structure of Structure of Human POT1C, PDB code: 7s1o was solved by T.Aramburu, E.Skordalakes, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.98 / 2.55
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	61.98, 61.8, 83.74, 90, 94.5, 90
R / Rfree (%)	22 / 27.1

The binding sites of Zinc atom in the Structure of Human POT1C (pdb code 7s1o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Human POT1C, PDB code: 7s1o:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Human POT1C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human POT1C within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn700 b:55.8 occ:1.00 SG A:CYS503 2.3 52.6 1.0 SG A:CYS382 2.3 47.9 1.0 SG A:CYS385 2.3 92.2 1.0 SG A:CYS506 2.3 59.8 1.0 CB A:CYS385 3.0 52.6 1.0 CB A:CYS382 3.2 38.0 1.0 CB A:CYS506 3.2 46.7 1.0 CB A:CYS503 3.3 43.4 1.0 N A:CYS385 3.4 47.8 1.0 CA A:CYS385 3.8 50.8 1.0 N A:CYS506 4.0 46.1 1.0 CA A:CYS506 4.2 40.1 1.0 CB A:LYS384 4.5 53.5 1.0 C A:LYS384 4.6 53.3 1.0 CA A:CYS382 4.6 45.3 1.0 C A:CYS385 4.7 59.5 1.0 CA A:CYS503 4.7 48.0 1.0 N A:HIS386 4.8 56.4 1.0 N A:LYS384 4.9 56.5 1.0 CA A:LYS384 4.9 54.1 1.0 C A:GLN505 4.9 52.8 1.0 CG1 A:VAL536 5.0 44.5 1.0

Zinc binding site 2 out of 2 in the Structure of Human POT1C


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Human POT1C within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn700 b:56.5 occ:1.00 SG B:CYS506 2.3 62.8 1.0 SG B:CYS503 2.3 50.1 1.0 SG B:CYS382 2.4 136.9 1.0 CB B:CYS385 2.7 52.6 1.0 CB B:CYS503 3.2 51.1 1.0 CB B:CYS506 3.3 52.5 1.0 CB B:CYS382 3.3 61.5 1.0 N B:CYS385 3.6 62.7 1.0 CA B:CYS385 3.7 51.5 1.0 SG B:CYS385 3.9 81.7 1.0 N B:CYS506 4.0 54.2 1.0 CA B:CYS506 4.3 54.8 1.0 CA B:CYS503 4.6 40.8 1.0 CA B:CYS382 4.6 53.7 1.0 CB B:GLN505 4.8 58.5 1.0 C B:LYS384 4.8 58.6 1.0 C B:CYS385 4.9 59.9 1.0

T.Aramburu, J.Kelich, C.Rice, E.Skordalakes. POT1-TPP1 Binding Stabilizes POT1, Promoting Efficient Telomere Maintenance. Comput Struct Biotechnol J V. 20 675 2022.
ISSN: ESSN 2001-0370
PubMed: 35140887
DOI: 10.1016/J.CSBJ.2022.01.005