Zinc in PDB 7raj: Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3

The structure of Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3, PDB code: 7raj was solved by P.Tripathi, P.D.Kwong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.79 / 3.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	37.281, 89.712, 72.044, 90, 99.27, 90
R / Rfree (%)	25.3 / 31.7

The binding sites of Zinc atom in the Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3 (pdb code 7raj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3, PDB code: 7raj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3 within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn301 b:63.9 occ:1.00 OD1 L:ASN137 2.2 63.0 1.0 NE2 H:HIS164 2.3 62.4 1.0 OD1 L:ASN138 2.5 63.4 1.0 ND2 L:ASN137 2.5 63.2 1.0 CG L:ASN137 2.7 63.3 1.0 CD2 H:HIS164 2.7 62.1 1.0 CG L:ASN138 3.2 63.3 1.0 ND2 L:ASN138 3.4 63.5 1.0 CE1 H:HIS164 3.6 62.5 1.0 O H:GLY162 3.9 62.5 1.0 OG1 H:THR183 3.9 64.1 1.0 CG H:HIS164 4.0 61.7 1.0 CA H:GLY162 4.0 62.5 1.0 CB L:ASN137 4.1 63.2 1.0 C H:GLY162 4.3 62.5 1.0 ND1 H:HIS164 4.4 62.3 1.0 OG L:SER174 4.4 63.1 1.0 CB L:ASN138 4.6 63.4 1.0 N L:ASN138 4.7 63.4 1.0 CA L:ASN137 4.9 63.1 1.0 CG2 H:THR183 4.9 65.1 1.0

Zinc binding site 2 out of 2 in the Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Pfcsp Peptide 21 with Antibody Igl-CIS43.D3 within 5.0Å range: probe atom residue distance (Å) B Occ L:Zn302 b:78.9 occ:1.00 OD2 L:ASP151 1.8 73.8 1.0 ND1 L:HIS189 2.3 72.6 1.0 CG L:ASP151 2.9 74.2 1.0 CE1 L:HIS189 3.0 72.5 1.0 CG L:HIS189 3.5 72.2 1.0 CB L:ASP151 3.5 74.8 1.0 O L:LYS188 3.6 71.9 1.0 CA L:HIS189 4.0 72.1 1.0 OD1 L:ASP151 4.0 74.3 1.0 CB L:HIS189 4.0 72.1 1.0 NE2 L:HIS189 4.2 72.4 1.0 CD2 L:HIS189 4.5 72.0 1.0 C L:LYS188 4.5 71.3 1.0 N L:HIS189 4.7 71.4 1.0

S.Kratochvil, C.H.Shen, Y.C.Lin, K.Xu, U.Nair, L.Da Silva Pereira, P.Tripathi, J.Arnold, G.Y.Chuang, E.Melzi, A.Schon, B.Zhang, M.Dillon, B.Bonilla, B.J.Flynn, K.H.Kirsch, N.K.Kisalu, P.K.Kiyuka, T.Liu, L.Ou, M.Pancera, R.Rawi, M.Reveiz, K.Seignon, L.T.Wang, M.T.Waring, J.Warner, Y.Yang, J.R.Francica, A.H.Idris, R.A.Seder, P.D.Kwong, F.D.Batista. Vaccination in A Humanized Mouse Model Elicits Highly Protective Pfcsp-Targeting Anti-Malarial Antibodies. Immunity 2021.
ISSN: ISSN 1074-7613
PubMed: 34788599
DOI: 10.1016/J.IMMUNI.2021.10.017