Zinc in PDB 7r1a: Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2

All present enzymatic activity of Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2:
3.4.17.23;

The binding sites of Zinc atom in the Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2 (pdb code 7r1a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2, PDB code: 7r1a:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn901 b:432.7 occ:1.00 OE1 D:GLU402 2.2 366.5 1.0 NE2 D:HIS378 2.3 363.9 1.0 NE2 D:HIS374 2.3 366.5 1.0 CE1 D:HIS378 2.6 363.9 1.0 OE2 D:GLU402 2.8 366.5 1.0 CD D:GLU402 2.8 366.5 1.0 CD2 D:HIS374 3.1 366.5 1.0 CE1 D:HIS374 3.4 366.5 1.0 CD2 D:HIS378 3.5 363.9 1.0 ND1 D:HIS378 3.8 363.9 1.0 CG D:HIS378 4.2 363.9 1.0 CG D:GLU402 4.3 366.5 1.0 CG D:HIS374 4.3 366.5 1.0 ND1 D:HIS374 4.4 366.5 1.0 OE1 D:GLU375 4.6 362.8 1.0 CB D:GLU402 4.8 366.5 1.0 CA D:GLU402 4.8 366.5 1.0

Zinc binding site 2 out of 3 in the Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn901 b:432.7 occ:1.00 OE1 E:GLU402 2.2 366.5 1.0 NE2 E:HIS378 2.3 363.9 1.0 NE2 E:HIS374 2.3 366.5 1.0 CE1 E:HIS378 2.6 363.9 1.0 OE2 E:GLU402 2.8 366.5 1.0 CD E:GLU402 2.8 366.5 1.0 CD2 E:HIS374 3.1 366.5 1.0 CE1 E:HIS374 3.4 366.5 1.0 CD2 E:HIS378 3.5 363.9 1.0 ND1 E:HIS378 3.8 363.9 1.0 CG E:HIS378 4.2 363.9 1.0 CG E:GLU402 4.3 366.5 1.0 CG E:HIS374 4.3 366.5 1.0 ND1 E:HIS374 4.4 366.5 1.0 OE1 E:GLU375 4.6 362.8 1.0 CB E:GLU402 4.8 366.5 1.0 CA E:GLU402 4.8 366.5 1.0

Zinc binding site 3 out of 3 in the Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Furin Cleaved Alpha Variant Sars-Cov-2 Spike in Complex with 3 ACE2 within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn901 b:432.7 occ:1.00 OE1 F:GLU402 2.2 366.5 1.0 NE2 F:HIS378 2.3 363.9 1.0 NE2 F:HIS374 2.3 366.5 1.0 CE1 F:HIS378 2.6 363.9 1.0 OE2 F:GLU402 2.8 366.5 1.0 CD F:GLU402 2.8 366.5 1.0 CD2 F:HIS374 3.1 366.5 1.0 CE1 F:HIS374 3.4 366.5 1.0 CD2 F:HIS378 3.5 363.9 1.0 ND1 F:HIS378 3.8 363.9 1.0 CG F:HIS378 4.2 363.9 1.0 CG F:GLU402 4.3 366.5 1.0 CG F:HIS374 4.3 366.5 1.0 ND1 F:HIS374 4.4 366.5 1.0 OE1 F:GLU375 4.6 362.8 1.0 CB F:GLU402 4.8 366.5 1.0 CA F:GLU402 4.8 366.5 1.0

A.G.Wrobel, D.J.Benton, C.Roustan, A.Borg, S.Hussain, S.R.Martin, P.B.Rosenthal, J.J.Skehel, S.J.Gamblin. Evolution of the Sars-Cov-2 Spike Protein in the Human Host. Nat Commun V. 13 1178 2022.
ISSN: ESSN 2041-1723
PubMed: 35246509
DOI: 10.1038/S41467-022-28768-W