Zinc in PDB 7pjg: Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

Enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria

All present enzymatic activity of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria:
3.5.1.108;

Protein crystallography data

The structure of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pjg was solved by M.D.Ryan, T.D.Pallin, M.B.A.C.Lamers, P.M.Leonard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.62 / 2.04
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 35.62, 66.61, 62.97, 90, 90.89, 90
R / Rfree (%) 19.8 / 25.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria (pdb code 7pjg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria, PDB code: 7pjg:

Zinc binding site 1 out of 1 in 7pjg

Go back to Zinc Binding Sites List in 7pjg
Zinc binding site 1 out of 1 in the Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug- Resistant Gram-Negative Bacteria within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:33.8
occ:1.00
 NE2 A:HIS237 2.0 37.7 1.0
N3 A:7S2502 2.0 34.6 1.0
OD1 A:ASP241 2.0 35.1 1.0
NE2 A:HIS78 2.1 33.4 1.0
O7 A:7S2502 2.5 31.1 1.0
CG A:ASP241 2.7 36.0 1.0
OD2 A:ASP241 2.8 37.6 1.0
CE1 A:HIS237 2.9 36.0 1.0
C2 A:7S2502 2.9 35.6 1.0
C1 A:7S2502 3.0 34.7 1.0
CD2 A:HIS237 3.0 32.7 1.0
CE1 A:HIS78 3.0 33.1 1.0
C4 A:7S2502 3.0 37.0 1.0
CD2 A:HIS78 3.1 32.0 1.0
ND1 A:HIS237 4.0 34.4 1.0
OE2 A:GLU77 4.1 36.2 1.0
CG A:HIS237 4.1 33.2 1.0
ND1 A:HIS78 4.1 37.7 1.0
N8 A:7S2502 4.2 33.0 1.0
CG A:HIS78 4.2 33.7 1.0
CB A:ASP241 4.2 31.5 1.0
C6 A:7S2502 4.2 37.0 1.0
C5 A:7S2502 4.2 39.8 1.0
CB A:THR190 4.3 32.9 1.0
CG A:GLU77 4.3 35.3 1.0
OG1 A:THR190 4.4 33.2 1.0
CD A:GLU77 4.7 35.8 1.0
CA A:THR190 4.7 32.3 1.0
O A:HIS237 4.8 29.6 1.0
CA A:ASP241 4.8 33.1 1.0
C9 A:7S2502 5.0 31.4 1.0

Reference:

M.D.Ryan, T.D.Pallin, T.Mullins, T.Blench, I.Fraser, J.Dallow, N.Ahmed, C.Ellwood, S.Gaines, J.Flores, Y.Blackwell, C.T.Garcia, G.Spence, A.Reeve, T.Panchal, B.Dominguez-Fernandez, P.M.Leonard, M.B.A.C.Lamers, A.Arduin, C.Fotinou, E.Gancia, D.E.Clark, E.Bush, J.Betts, C.Richards, T.Rea-Davies, A.D.Keefe, Y.Zhang, H.T.Soutter, P.A.Centrella, M.A.Clark, J.W.Cuozzo, C.E.Dumelin, S.Habeshian, A.Hunt, E.A.Sigel, D.M.Troast, B.L.M.Dejonge. Lpxc Inhibitors with Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic with Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published.
Page generated: Wed Oct 30 09:11:59 2024

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