Zinc in PDB 7pgu: Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc.

The binding sites of Zinc atom in the Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc. (pdb code 7pgu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc., PDB code: 7pgu:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc. within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn2902 b:123.3 occ:1.00 O F:HOH3001 2.0 74.5 1.0 NE2 F:HIS1558 2.0 68.1 1.0 SG F:CYS1032 2.0 67.4 1.0 NE2 F:HIS1576 2.1 89.3 1.0 CE1 F:HIS1576 2.7 89.3 1.0 HE1 F:HIS1576 2.8 89.3 1.0 CE1 F:HIS1558 3.0 68.1 1.0 CD2 F:HIS1558 3.1 68.1 1.0 HE1 F:HIS1558 3.2 68.1 1.0 CD2 F:HIS1576 3.2 89.3 1.0 HD2 F:HIS1558 3.3 68.1 1.0 CB F:CYS1032 3.5 67.4 1.0 HD2 F:HIS1576 3.5 89.3 1.0 HB3 F:CYS1032 3.6 67.4 1.0 HA F:CYS1032 3.6 67.4 1.0 ND1 F:HIS1576 3.9 89.3 1.0 ND1 F:HIS1558 4.1 68.1 1.0 CA F:CYS1032 4.1 67.4 1.0 CG F:HIS1576 4.1 89.3 1.0 CG F:HIS1558 4.2 68.1 1.0 HB2 F:CYS1032 4.2 67.4 1.0 HZ1 F:LYS1581 4.2 102.0 1.0 HZ2 F:LYS1581 4.5 102.0 1.0 HZ F:PHE1572 4.7 82.6 1.0 HE3 F:LYS1581 4.7 102.0 1.0 NZ F:LYS1581 4.8 102.0 1.0 HG F:SER987 4.9 63.6 1.0 HD1 F:HIS1558 4.9 68.1 1.0 N F:CYS1032 4.9 67.4 1.0

Zinc binding site 2 out of 2 in the Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Autoinhibited Structure of Human Neurofibromin Isoform 2 Stabilized By Zinc. within 5.0Å range: probe atom residue distance (Å) B Occ N:Zn2902 b:132.5 occ:1.00 O N:HOH3001 2.0 83.1 1.0 NE2 N:HIS1558 2.0 73.8 1.0 SG N:CYS1032 2.0 77.0 1.0 NE2 N:HIS1576 2.1 94.9 1.0 CE1 N:HIS1576 2.6 94.9 1.0 HE1 N:HIS1576 2.7 94.9 1.0 CD2 N:HIS1558 3.0 73.8 1.0 CE1 N:HIS1558 3.0 73.8 1.0 CD2 N:HIS1576 3.1 94.9 1.0 HD2 N:HIS1558 3.2 73.8 1.0 HE1 N:HIS1558 3.2 73.8 1.0 HD2 N:HIS1576 3.5 94.9 1.0 CB N:CYS1032 3.6 77.0 1.0 HB3 N:CYS1032 3.7 77.0 1.0 ND1 N:HIS1576 3.7 94.9 1.0 HA N:CYS1032 3.9 77.0 1.0 CG N:HIS1576 4.0 94.9 1.0 ND1 N:HIS1558 4.1 73.8 1.0 CG N:HIS1558 4.1 73.8 1.0 HB2 N:CYS1032 4.2 77.0 1.0 HZ1 N:LYS1581 4.3 104.8 1.0 CA N:CYS1032 4.3 77.0 1.0 HZ N:PHE1572 4.4 88.9 1.0 HE3 N:LYS1581 4.5 104.8 1.0 HD21 N:ASN1619 4.6 84.0 1.0 HZ2 N:LYS1581 4.6 104.8 1.0 HD22 N:ASN1619 4.7 84.0 1.0 NZ N:LYS1581 4.8 104.8 1.0 HD1 N:HIS1558 4.9 73.8 1.0 ND2 N:ASN1619 4.9 84.0 1.0

A.Naschberger, R.Baradaran, B.Rupp, M.Carroni. The Structure of Neurofibromin Isoform 2 Reveals Different Functional States. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 34707296
DOI: 10.1038/S41586-021-04024-X