Zinc in PDB 7p49: Hla-E*01:03 in Complex with MTB14

All present enzymatic activity of Hla-E*01:03 in Complex with MTB14:
2.3.1.292;

The structure of Hla-E*01:03 in Complex with MTB14, PDB code: 7p49 was solved by L.C.Walters, G.M.Gillespie, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.16 / 2.05
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	245.15, 47.926, 152.445, 90, 117.45, 90
R / Rfree (%)	23.7 / 27.9

The binding sites of Zinc atom in the Hla-E*01:03 in Complex with MTB14 (pdb code 7p49). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hla-E*01:03 in Complex with MTB14, PDB code: 7p49:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Hla-E*01:03 in Complex with MTB14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hla-E*01:03 in Complex with MTB14 within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn302 b:45.7 occ:0.50 OE2 E:GLU183 2.1 43.4 1.0 NE2 E:HIS181 2.3 43.1 1.0 CD E:GLU183 2.7 42.5 1.0 OE1 E:GLU183 2.8 42.9 1.0 CD2 E:HIS181 3.0 41.4 1.0 CE1 E:HIS181 3.4 42.0 1.0 CG E:GLU183 4.1 39.2 1.0 CG E:HIS181 4.2 42.6 1.0 ND1 E:HIS181 4.4 42.4 1.0 CB E:GLU183 4.5 37.2 1.0 CA E:GLU183 4.6 38.3 1.0 O E:LEU182 4.6 43.5 1.0

Zinc binding site 2 out of 2 in the Hla-E*01:03 in Complex with MTB14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hla-E*01:03 in Complex with MTB14 within 5.0Å range: probe atom residue distance (Å) B Occ G:Zn302 b:40.0 occ:0.50 OE2 G:GLU183 1.9 44.1 1.0 NE2 G:HIS181 2.3 39.2 1.0 O G:HOH406 2.6 42.1 0.5 CD G:GLU183 2.8 40.3 1.0 CD2 G:HIS181 3.0 36.4 1.0 OE1 G:GLU183 3.2 40.1 1.0 CE1 G:HIS181 3.4 38.8 1.0 O G:HOH446 3.6 41.1 1.0 CG G:GLU183 4.0 39.4 1.0 O G:HOH407 4.1 40.8 1.0 CG G:HIS181 4.2 36.3 1.0 ND1 G:HIS181 4.4 36.6 1.0 O G:LEU182 4.5 37.4 1.0 CA G:GLU183 4.9 33.5 1.0

L.C.Walters, D.Rozbesky, K.Harlos, M.Quastel, H.Sun, S.Springer, R.P.Rambo, F.Mohammed, E.Y.Jones, A.J.Mcmichael, G.M.Gillespie. Primary and Secondary Functions of Hla-E Are Determined By Stability and Conformation of the Peptide-Bound Complexes. Cell Rep V. 39 10959 2022.
ISSN: ESSN 2211-1247
PubMed: 35705051
DOI: 10.1016/J.CELREP.2022.110959