Zinc in PDB 7nh7: OC43 Coronavirus Methyltransferase

Enzymatic activity of OC43 Coronavirus Methyltransferase

All present enzymatic activity of OC43 Coronavirus Methyltransferase:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

Protein crystallography data

The structure of OC43 Coronavirus Methyltransferase, PDB code: 7nh7 was solved by P.Dostalik, P.Krafcikova, E.Boura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.35 / 2.20
Space group P 31
Cell size a, b, c (Å), α, β, γ (°) 61.945, 61.945, 109.717, 90, 90, 120
R / Rfree (%) 16.4 / 21.1

Zinc Binding Sites:

The binding sites of Zinc atom in the OC43 Coronavirus Methyltransferase (pdb code 7nh7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the OC43 Coronavirus Methyltransferase, PDB code: 7nh7:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7nh7

Go back to Zinc Binding Sites List in 7nh7
Zinc binding site 1 out of 2 in the OC43 Coronavirus Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of OC43 Coronavirus Methyltransferase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn201

b:51.0
occ:1.00
SG B:CYS116 2.3 49.3 1.0
SG B:CYS127 2.3 49.9 1.0
SG B:CYS129 2.3 58.5 1.0
SG B:CYS119 2.4 45.9 1.0
CB B:CYS116 3.0 47.0 1.0
CB B:CYS119 3.3 37.9 1.0
CB B:CYS129 3.3 55.5 1.0
CB B:CYS127 3.5 55.4 1.0
N B:CYS119 3.8 46.4 1.0
N B:CYS129 3.9 49.6 1.0
CG2 B:VAL118 4.0 51.1 1.0
CA B:CYS119 4.1 42.2 1.0
CA B:CYS127 4.2 49.4 1.0
CA B:CYS129 4.2 57.2 1.0
N B:SER128 4.3 57.8 1.0
CA B:CYS116 4.4 47.8 1.0
NE B:ARG123 4.5 51.4 1.0
NH2 B:ARG123 4.6 47.4 1.0
C B:CYS127 4.6 53.0 1.0
C B:CYS119 4.9 45.7 1.0
C B:CYS116 4.9 46.1 1.0
C B:VAL118 4.9 46.4 1.0
N B:GLY120 4.9 43.6 1.0

Zinc binding site 2 out of 2 in 7nh7

Go back to Zinc Binding Sites List in 7nh7
Zinc binding site 2 out of 2 in the OC43 Coronavirus Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of OC43 Coronavirus Methyltransferase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn202

b:26.2
occ:1.00
NE2 B:HIS83 2.0 21.8 1.0
SG B:CYS74 2.3 20.4 1.0
SG B:CYS77 2.3 23.6 1.0
SG B:CYS90 2.3 24.0 1.0
CE1 B:HIS83 2.9 25.3 1.0
CD2 B:HIS83 3.0 17.3 1.0
CB B:CYS90 3.2 26.6 1.0
CB B:CYS74 3.3 22.4 1.0
CB B:CYS77 3.4 23.0 1.0
N B:CYS77 3.5 18.3 1.0
CA B:CYS77 3.9 23.6 1.0
ND1 B:HIS83 4.1 22.7 1.0
CG B:HIS83 4.1 24.1 1.0
CB B:TYR76 4.4 18.1 1.0
C B:TYR76 4.5 20.8 1.0
CA B:CYS90 4.5 23.9 1.0
CA B:CYS74 4.7 23.2 1.0
CB B:ARG93 4.8 25.6 1.0
N B:ARG93 4.9 20.4 1.0
CA B:TYR76 4.9 19.1 1.0
O B:HOH342 4.9 40.5 1.0
O B:CYS74 5.0 23.8 1.0

Reference:

P.Dostalik, P.Krafcikova, E.Boura. OC43 Coronavirus Methyltransferase To Be Published.
Page generated: Mon Jul 12 17:27:19 2021

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