Zinc in PDB 7mfe: Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved

All present enzymatic activity of Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved:
2.7.11.1;

The binding sites of Zinc atom in the Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved (pdb code 7mfe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved, PDB code: 7mfe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:56.1 occ:1.00 ND1 A:HIS269 2.3 28.7 1.0 SG A:CYS248 2.3 14.2 1.0 CB A:HIS269 2.8 28.7 1.0 CG A:HIS269 2.9 28.7 1.0 CA A:HIS269 3.2 28.7 1.0 CE1 A:HIS269 3.5 28.7 1.0 CB A:CYS248 3.6 14.2 1.0 SG A:CYS251 3.9 15.3 1.0 N A:HIS269 3.9 28.7 1.0 CD2 A:HIS269 4.2 28.7 1.0 CB A:PHE250 4.3 28.1 1.0 NE2 A:HIS269 4.4 28.7 1.0 C A:HIS269 4.5 28.7 1.0 OE1 A:GLN270 4.5 21.5 1.0 C A:PHE268 4.5 17.8 1.0 N A:CYS251 4.5 15.3 1.0 O A:PHE268 4.6 17.8 1.0 N A:GLN270 4.6 21.5 1.0 N A:PHE250 4.8 28.1 1.0 CB A:CYS251 4.8 15.3 1.0 CA A:CYS248 4.9 14.2 1.0 CA A:PHE250 5.0 28.1 1.0 NE2 A:GLN270 5.0 21.5 1.0

Zinc binding site 2 out of 2 in the Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Autoinhibited Braf:(14-3-3)2 Complex with the Braf Rbd Resolved within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:27.8 occ:1.00 ND1 A:HIS235 1.5 22.4 1.0 CG A:HIS235 1.7 22.4 1.0 CE1 A:HIS235 2.0 22.4 1.0 CD2 A:HIS235 2.2 22.4 1.0 SG A:CYS264 2.3 19.8 1.0 NE2 A:HIS235 2.3 22.4 1.0 CB A:CYS264 2.6 19.8 1.0 CB A:HIS235 2.7 22.4 1.0 CA A:HIS235 3.7 22.4 1.0 CB A:CYS261 3.9 17.8 1.0 CA A:CYS264 4.1 19.8 1.0 SG A:CYS261 4.2 17.8 1.0 N A:HIS235 4.5 22.4 1.0 N A:CYS264 4.5 19.8 1.0 C A:HIS235 4.9 22.4 1.0 CB A:TYR266 4.9 31.5 1.0 N A:ASN236 5.0 20.4 1.0

J.A.Martinez Fiesco, D.E.Durrant, D.K.Morrison, P.Zhang. Structural Insights Into the Braf Monomer-to-Dimer Transition Mediated By Ras Binding. Nat Commun V. 13 486 2022.
ISSN: ESSN 2041-1723
PubMed: 35078985
DOI: 10.1038/S41467-022-28084-3