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Zinc in PDB 7lzb: Crystal Structure of SETD2 Bound to Compound 2Enzymatic activity of Crystal Structure of SETD2 Bound to Compound 2
All present enzymatic activity of Crystal Structure of SETD2 Bound to Compound 2:
2.1.1.359; Protein crystallography data
The structure of Crystal Structure of SETD2 Bound to Compound 2, PDB code: 7lzb
was solved by
N.A.Farrow,
P.Boriack-Sjodin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of SETD2 Bound to Compound 2
(pdb code 7lzb). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of SETD2 Bound to Compound 2, PDB code: 7lzb: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 7lzbGo back to Zinc Binding Sites List in 7lzb
Zinc binding site 1 out
of 3 in the Crystal Structure of SETD2 Bound to Compound 2
Mono view Stereo pair view
Zinc binding site 2 out of 3 in 7lzbGo back to Zinc Binding Sites List in 7lzb
Zinc binding site 2 out
of 3 in the Crystal Structure of SETD2 Bound to Compound 2
Mono view Stereo pair view
Zinc binding site 3 out of 3 in 7lzbGo back to Zinc Binding Sites List in 7lzb
Zinc binding site 3 out
of 3 in the Crystal Structure of SETD2 Bound to Compound 2
Mono view Stereo pair view
Reference:
J.W.Lampe,
J.S.Alford,
P.A.Boriak-Sjodin,
D.Brach,
K.Cosmopoulos,
K.W.Duncan,
S.T.Eckley,
M.A.Foley,
D.M.Harvey,
V.Motwani,
M.J.Munchhof,
A.Raimondi,
T.V.Riera,
C.Tang,
M.J.Thomenius,
J.Totman,
N.A.Farrow.
Discovery of A First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable For Preclinical Studies Acs Med.Chem.Lett. 2021.
Page generated: Tue Oct 29 23:05:20 2024
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.1C00272 |
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