Zinc in PDB 7lhe: Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State

The binding sites of Zinc atom in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State (pdb code 7lhe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State, PDB code: 7lhe:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2805 b:127.2 occ:1.00 CB A:CYS2614 1.7 107.9 1.0 NE2 A:HIS2631 2.0 113.8 1.0 ND1 A:HIS2636 2.1 109.8 1.0 SG A:CYS2614 2.3 107.9 1.0 SG A:CYS2611 2.3 105.1 1.0 CG A:HIS2636 2.8 109.8 1.0 CE1 A:HIS2631 3.0 113.8 1.0 CB A:HIS2636 3.0 109.8 1.0 CD2 A:HIS2631 3.0 113.8 1.0 CA A:CYS2614 3.2 107.9 1.0 CE1 A:HIS2636 3.2 109.8 1.0 N A:CYS2614 3.6 107.9 1.0 CB A:CYS2611 3.6 105.1 1.0 CD2 A:HIS2636 4.1 109.8 1.0 ND1 A:HIS2631 4.1 113.8 1.0 CG A:HIS2631 4.1 113.8 1.0 NE2 A:HIS2636 4.2 109.8 1.0 C A:CYS2614 4.2 107.9 1.0 CA A:HIS2636 4.5 109.8 1.0 N A:GLY2615 4.7 106.4 1.0 O A:HIS2631 4.9 113.8 1.0 C A:ILE2613 4.9 99.1 1.0 CA A:CYS2611 5.0 105.1 1.0

Zinc binding site 2 out of 4 in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn2805 b:126.9 occ:1.00 CB D:CYS2614 1.7 107.9 1.0 NE2 D:HIS2631 2.0 113.8 1.0 ND1 D:HIS2636 2.1 109.8 1.0 SG D:CYS2614 2.3 107.9 1.0 SG D:CYS2611 2.3 105.1 1.0 CG D:HIS2636 2.9 109.8 1.0 CE1 D:HIS2631 3.0 113.8 1.0 CB D:HIS2636 3.0 109.8 1.0 CD2 D:HIS2631 3.0 113.8 1.0 CA D:CYS2614 3.2 107.9 1.0 CE1 D:HIS2636 3.2 109.8 1.0 CB D:CYS2611 3.6 105.1 1.0 N D:CYS2614 3.6 107.9 1.0 ND1 D:HIS2631 4.1 113.8 1.0 CD2 D:HIS2636 4.1 109.8 1.0 CG D:HIS2631 4.1 113.8 1.0 NE2 D:HIS2636 4.2 109.8 1.0 C D:CYS2614 4.2 107.9 1.0 CA D:HIS2636 4.5 109.8 1.0 N D:GLY2615 4.7 106.4 1.0 O D:HIS2631 4.9 113.8 1.0 C D:ILE2613 4.9 99.1 1.0 CA D:CYS2611 5.0 105.1 1.0

Zinc binding site 3 out of 4 in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn2806 b:126.2 occ:1.00 CB C:CYS2614 1.7 107.9 1.0 NE2 C:HIS2631 2.0 113.8 1.0 ND1 C:HIS2636 2.1 109.8 1.0 SG C:CYS2614 2.3 107.9 1.0 SG C:CYS2611 2.3 105.1 1.0 CG C:HIS2636 2.9 109.8 1.0 CE1 C:HIS2631 3.0 113.8 1.0 CB C:HIS2636 3.0 109.8 1.0 CD2 C:HIS2631 3.0 113.8 1.0 CA C:CYS2614 3.2 107.9 1.0 CE1 C:HIS2636 3.2 109.8 1.0 CB C:CYS2611 3.6 105.1 1.0 N C:CYS2614 3.6 107.9 1.0 CD2 C:HIS2636 4.1 109.8 1.0 ND1 C:HIS2631 4.1 113.8 1.0 CG C:HIS2631 4.1 113.8 1.0 NE2 C:HIS2636 4.2 109.8 1.0 C C:CYS2614 4.2 107.9 1.0 CA C:HIS2636 4.5 109.8 1.0 N C:GLY2615 4.7 106.4 1.0 O C:HIS2631 4.9 113.8 1.0 C C:ILE2613 4.9 99.1 1.0 CA C:CYS2611 5.0 105.1 1.0

Zinc binding site 4 out of 4 in the Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Full-Length IP3R1 Channel Reconstituted Into Lipid Nanodisc in the Apo-State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2809 b:126.2 occ:1.00 CB B:CYS2614 1.7 107.9 1.0 ND1 B:HIS2636 2.0 109.8 1.0 NE2 B:HIS2631 2.0 113.8 1.0 SG B:CYS2614 2.2 107.9 1.0 SG B:CYS2611 2.4 105.1 1.0 CG B:HIS2636 2.8 109.8 1.0 CE1 B:HIS2631 2.9 113.8 1.0 CB B:HIS2636 3.0 109.8 1.0 CD2 B:HIS2631 3.0 113.8 1.0 CE1 B:HIS2636 3.1 109.8 1.0 CA B:CYS2614 3.1 107.9 1.0 N B:CYS2614 3.6 107.9 1.0 CB B:CYS2611 3.7 105.1 1.0 ND1 B:HIS2631 4.0 113.8 1.0 CD2 B:HIS2636 4.0 109.8 1.0 CG B:HIS2631 4.1 113.8 1.0 NE2 B:HIS2636 4.1 109.8 1.0 C B:CYS2614 4.2 107.9 1.0 CA B:HIS2636 4.5 109.8 1.0 N B:GLY2615 4.6 106.4 1.0 O B:HIS2631 4.9 113.8 1.0 C B:ILE2613 4.9 99.1 1.0

M.R.Baker, G.Fan, A.B.Seryshev, M.A.Agosto, M.L.Baker, I.I.Serysheva. Cryo-Em Structure of Type 1 IP3R Channel in A Lipid Bilayer Commun Biol V. 4 625 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-02156-4