Zinc in PDB 7lf3: C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836

The structure of C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836, PDB code: 7lf3 was solved by S.S.Katti, I.V.Krieger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.79 / 1.13
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	34.913, 25.943, 57.642, 90, 92.57, 90
R / Rfree (%)	18.3 / 19.9

The binding sites of Zinc atom in the C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836 (pdb code 7lf3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836, PDB code: 7lf3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:17.0 occ:1.00 ND1 A:HIS231 2.1 16.2 1.0 SG A:CYS280 2.3 18.8 1.0 SG A:CYS261 2.3 14.7 1.0 SG A:CYS264 2.3 18.9 1.0 CE1 A:HIS231 3.0 17.4 1.0 CG A:HIS231 3.2 14.6 1.0 CB A:CYS261 3.2 13.6 1.0 CB A:CYS264 3.3 23.6 1.0 CB A:CYS280 3.3 21.2 1.0 CB A:HIS231 3.6 16.4 1.0 N A:CYS264 3.7 18.0 1.0 CA A:HIS231 3.8 13.9 1.0 CA A:CYS280 4.0 19.8 1.0 CA A:CYS264 4.1 19.2 1.0 O A:HOH459 4.1 34.6 1.0 NE2 A:HIS231 4.1 17.9 1.0 CD2 A:HIS231 4.3 16.7 1.0 CB A:ASP263 4.6 18.2 1.0 C A:ASP263 4.7 21.2 1.0 CA A:CYS261 4.7 12.3 1.0 N A:HIS231 4.7 16.3 1.0 N A:ARG232 4.7 13.9 1.0 C A:CYS280 4.8 29.8 1.0 C A:CYS264 4.8 19.6 1.0 C A:HIS231 4.8 14.7 1.0 CB A:MET266 4.9 17.6 1.0 N A:ASP263 4.9 16.9 1.0 N A:GLY265 5.0 19.9 1.0 CA A:ASP263 5.0 18.6 1.0

Zinc binding site 2 out of 2 in the C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of C1B Domain of Protein Kinase C in Complex with Diacylglycerol-Lactone Ajh-836 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:15.4 occ:1.00 ND1 A:HIS269 2.1 15.8 1.0 SG A:CYS247 2.3 16.3 1.0 SG A:CYS272 2.3 15.9 1.0 SG A:CYS244 2.3 13.9 1.0 CE1 A:HIS269 3.0 15.2 1.0 CB A:CYS244 3.1 13.8 1.0 CG A:HIS269 3.1 14.1 1.0 CB A:CYS247 3.3 15.6 1.0 CB A:CYS272 3.4 16.7 1.0 CB A:HIS269 3.5 14.3 1.0 N A:CYS247 3.8 14.9 1.0 N A:HIS269 3.9 13.9 1.0 CA A:CYS247 4.1 14.9 1.0 NE2 A:HIS269 4.1 16.9 1.0 CD2 A:HIS269 4.2 15.4 1.0 CA A:HIS269 4.4 13.2 1.0 CA A:CYS244 4.5 14.2 1.0 CA A:CYS272 4.7 16.0 1.0 CB A:HIS246 4.8 16.5 1.0 OG A:SER249 4.8 20.7 1.0 CD2 A:HIS246 4.8 16.7 1.0 O A:HOH456 4.8 44.6 1.0 C A:CYS247 4.8 16.5 1.0 C A:HIS246 4.9 16.4 1.0

S.S.Katti, I.V.Krieger, J.Ann, J.Lee, J.C.Sacchettini, T.I.Igumenova. Structural Anatomy of Protein Kinase C C1 Domain Interactions with Diacylglycerol and Other Agonists. Nat Commun V. 13 2695 2022.
ISSN: ESSN 2041-1723
PubMed: 35577811
DOI: 10.1038/S41467-022-30389-2