Zinc in PDB 7l6v: Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12

All present enzymatic activity of Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12:
3.4.24.69;

The structure of Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12, PDB code: 7l6v was solved by K.Lam, R.Jin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	116.52 / 2.01
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	115.899, 157.645, 173.001, 90, 90, 90
R / Rfree (%)	19.7 / 23.4

The binding sites of Zinc atom in the Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12 (pdb code 7l6v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12, PDB code: 7l6v:

Zinc binding site 1 out of 1 in the Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Bont/A-Lc-Jpu-A5-Jpu-C1-Jpu-H7-Jpu-D12-Cia-F12 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:36.8 occ:1.00 OE1 A:GLU262 2.2 37.5 1.0 OE2 A:GLU262 2.2 45.5 1.0 NE2 A:HIS223 2.2 35.5 1.0 NE2 A:HIS227 2.3 34.2 1.0 O A:HOH643 2.4 38.3 1.0 CD A:GLU262 2.5 38.2 1.0 O A:HOH719 2.6 34.1 1.0 CD2 A:HIS223 3.0 27.8 1.0 CD2 A:HIS227 3.0 28.8 1.0 CE1 A:HIS223 3.4 35.5 1.0 CE1 A:HIS227 3.4 40.4 1.0 OH A:TYR366 3.8 50.3 1.0 CG A:GLU262 4.0 45.5 1.0 CG A:HIS223 4.2 27.9 1.0 OE2 A:GLU224 4.3 37.1 1.0 O A:HOH802 4.3 42.3 1.0 CG A:HIS227 4.3 33.0 1.0 ND1 A:HIS223 4.4 34.9 1.0 CE1 A:TYR366 4.4 42.4 1.0 O A:HOH742 4.4 42.9 1.0 ND1 A:HIS227 4.4 36.2 1.0 CZ A:TYR366 4.5 48.1 1.0 CG2 A:THR265 4.7 29.1 1.0 CB A:GLU262 4.8 38.6 1.0 CA A:GLU262 4.9 35.8 1.0 CD A:GLU224 4.9 30.8 1.0 OE1 A:GLU224 5.0 34.1 1.0

K.Lam, R.Jin. Probing the Structure and Function of the Protease Domain of Botulinum Neurotoxins Using Single-Domain Antibodies. Plos Pathog. 2021.
ISSN: ESSN 1553-7374