Zinc in PDB 7l0n: Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity

Enzymatic activity of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity

All present enzymatic activity of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity:
3.4.17.23;

Protein crystallography data

The structure of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity, PDB code: 7l0n was solved by G.Snell, N.Czudnochowski, J.Dillen, J.C.Nix, T.I.Croll, D.Corti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.90 / 2.78
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 77.98, 186.58, 194.52, 90, 96.4, 90
R / Rfree (%) 29 / 32.5

Other elements in 7l0n:

The structure of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity also contains other interesting chemical elements:

Chlorine (Cl) 27 atoms
Sodium (Na) 6 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity (pdb code 7l0n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity, PDB code: 7l0n:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7l0n

Go back to Zinc Binding Sites List in 7l0n
Zinc binding site 1 out of 2 in the Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn701

b:95.6
occ:1.00
OE1 E:GLU402 2.1 105.0 1.0
NE2 E:HIS374 2.3 104.5 1.0
NE2 E:HIS378 2.4 87.3 1.0
CD E:GLU402 2.9 103.8 1.0
CE1 E:HIS378 3.0 87.7 1.0
CD2 E:HIS374 3.1 105.5 1.0
OE2 E:GLU402 3.2 104.8 1.0
CD2 E:HIS378 3.2 87.7 1.0
OE2 E:GLU375 3.3 92.1 1.0
CE1 E:HIS374 3.5 104.8 1.0
ND1 E:HIS378 3.9 87.8 1.0
CG E:HIS378 4.0 87.6 1.0
CD E:GLU375 4.0 92.7 1.0
OE1 E:GLU375 4.2 92.0 1.0
CG E:GLU402 4.2 101.0 1.0
CG E:HIS374 4.3 105.1 1.0
ND1 E:HIS374 4.4 105.5 1.0

Zinc binding site 2 out of 2 in 7l0n

Go back to Zinc Binding Sites List in 7l0n
Zinc binding site 2 out of 2 in the Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn701

b:77.7
occ:1.00
NE2 F:HIS374 2.0 67.9 1.0
OE2 F:GLU402 2.1 78.3 1.0
NE2 F:HIS378 2.2 63.0 1.0
CD F:GLU402 2.7 76.6 1.0
CD2 F:HIS374 2.8 68.3 1.0
OE1 F:GLU402 2.9 77.4 1.0
CE1 F:HIS378 3.0 63.4 1.0
CD2 F:HIS378 3.1 62.9 1.0
CE1 F:HIS374 3.2 68.4 1.0
OE1 F:GLU375 3.6 70.9 1.0
ND1 F:HIS378 4.0 63.1 1.0
CG F:HIS374 4.0 68.7 1.0
CG F:GLU402 4.0 74.8 1.0
CG F:HIS378 4.1 63.2 1.0
ND1 F:HIS374 4.2 68.8 1.0
CD F:GLU375 4.2 70.2 1.0
OE2 F:GLU375 4.4 70.2 1.0
CA F:GLU402 4.8 70.6 1.0
CB F:GLU402 4.9 72.6 1.0

Reference:

E.C.Thomson, L.E.Rosen, J.G.Shepherd, R.Spreafico, D.L.Robertson, G.Snell. Circulating Sars-Cov-2 Spike N439K Variants Maintain Fitness While Evading Antibody-Mediated Immunity To Be Published.
Page generated: Wed Mar 3 16:22:23 2021

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