Zinc in PDB 7kyf: Botulism Neurooxin Light Chain A App Form

Protein crystallography data

The structure of Botulism Neurooxin Light Chain A App Form, PDB code: 7kyf was solved by M.E.Ortega, N.T.Salzameda, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.25 / 2.33
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 57.527, 196.401, 38.775, 90, 90, 90
R / Rfree (%) 16 / 17.9

Other elements in 7kyf:

The structure of Botulism Neurooxin Light Chain A App Form also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Botulism Neurooxin Light Chain A App Form (pdb code 7kyf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Botulism Neurooxin Light Chain A App Form, PDB code: 7kyf:

Zinc binding site 1 out of 1 in 7kyf

Go back to Zinc Binding Sites List in 7kyf
Zinc binding site 1 out of 1 in the Botulism Neurooxin Light Chain A App Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Botulism Neurooxin Light Chain A App Form within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn501

b:356.2
occ:1.00
O03 C:XC1502 1.8 13.9 1.0
NE2 C:HIS227 2.0 49.6 1.0
O02 C:XC1502 2.1 15.9 1.0
OE2 C:GLU262 2.4 97.0 1.0
OE1 C:GLU262 2.4 76.2 1.0
N02 C:XC1502 2.5 15.2 1.0
C04 C:XC1502 2.6 16.2 1.0
CD C:GLU262 2.6 67.6 1.0
NE2 C:HIS223 2.9 41.0 1.0
CE1 C:HIS227 3.0 58.1 1.0
CD2 C:HIS227 3.0 46.6 1.0
CD2 C:HIS223 3.4 38.6 1.0
CG C:GLU262 3.9 68.0 1.0
C03 C:XC1502 4.0 15.4 1.0
OE2 C:GLU224 4.0 50.4 1.0
ND1 C:HIS227 4.1 51.0 1.0
CE1 C:HIS223 4.2 50.8 1.0
CG C:HIS227 4.2 47.9 1.0
OH C:TYR366 4.5 90.6 1.0
C05 C:XC1502 4.5 13.6 1.0
CG C:HIS223 4.7 34.2 1.0
CB C:GLU262 4.7 64.0 1.0
CD C:GLU224 4.8 34.5 1.0
OE1 C:GLU224 4.8 40.9 1.0
CA C:GLU262 4.9 45.2 1.0

Reference:

M.Amezcua, R.S.Cruz, A.Ku, W.Moran, M.E.Ortega, N.T.Salzameda. Discovery of Dipeptides As Potent Botulinum Neurotoxin A Light-Chain Inhibitors. Acs Med.Chem.Lett. V. 12 295 2021.
ISSN: ISSN 1948-5875
PubMed: 33603978
DOI: 10.1021/ACSMEDCHEMLETT.0C00674
Page generated: Sat Apr 17 17:48:41 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy