Zinc in PDB 7kcx: Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin

The structure of Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin, PDB code: 7kcx was solved by J.A.N.Alexander, N.C.J.Strynadka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.98 / 1.62
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.08, 82.7, 103.86, 90, 90, 90
R / Rfree (%)	17.6 / 20.4

The binding sites of Zinc atom in the Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin (pdb code 7kcx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin, PDB code: 7kcx:

Zinc binding site 1 out of 1 in the Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of S. Aureus Penicillin-Binding Protein 4 (PBP4) Mutant (R200L) in Complex with Cefoxitin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn404 b:48.3 occ:0.66 OD2 A:ASP364 2.0 52.8 1.0 O A:HOH687 2.1 56.5 1.0 NE2 A:HIS362 2.1 37.5 1.0 O A:HOH705 2.4 51.9 1.0 CG A:ASP364 2.6 51.5 1.0 OD1 A:ASP364 2.7 39.0 1.0 CE1 A:HIS362 3.0 41.2 1.0 CD2 A:HIS362 3.1 37.0 1.0 HE1 A:HIS362 3.2 49.5 1.0 HD2 A:HIS362 3.3 44.5 1.0 HG21 A:VAL355 3.9 50.8 1.0 HG2 A:PRO376 3.9 38.0 1.0 O A:HOH711 4.0 48.6 1.0 CB A:ASP364 4.1 39.2 1.0 HB A:VAL355 4.1 43.9 1.0 HG11 A:VAL355 4.1 52.8 1.0 ND1 A:HIS362 4.2 35.5 1.0 CG A:HIS362 4.2 34.9 1.0 HB2 A:ASP364 4.3 47.1 1.0 HB3 A:ASP364 4.5 47.1 1.0 HG12 A:VAL355 4.5 52.8 1.0 OE2 A:GLU357 4.6 63.8 1.0 CG2 A:VAL355 4.6 42.3 1.0 CG1 A:VAL355 4.6 44.0 1.0 CB A:VAL355 4.6 36.5 1.0 O A:HOH718 4.7 53.0 1.0 HA A:ASP364 4.8 40.6 1.0 HG23 A:VAL355 4.8 50.8 1.0 CG A:PRO376 4.9 31.7 1.0

J.A.N.Alexander, N.C.J.Strynadka. PBP4 Mediated Beta-Lactam Resistance Among Clinical Strains of Staphylococcus Aureus To Be Published.