Zinc in PDB 7k95: Crystal Structure of Human CPSF30 in Complex with HFIP1

Protein crystallography data

The structure of Crystal Structure of Human CPSF30 in Complex with HFIP1, PDB code: 7k95 was solved by K.Hamilton, L.Tong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.55 / 1.90
Space group P 64
Cell size a, b, c (Å), α, β, γ (°) 79.040, 79.040, 48.662, 90.00, 90.00, 120.00
R / Rfree (%) 17.9 / 20.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human CPSF30 in Complex with HFIP1 (pdb code 7k95). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human CPSF30 in Complex with HFIP1, PDB code: 7k95:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7k95

Go back to Zinc Binding Sites List in 7k95
Zinc binding site 1 out of 2 in the Crystal Structure of Human CPSF30 in Complex with HFIP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human CPSF30 in Complex with HFIP1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:45.3
occ:1.00
NE2 A:HIS142 2.1 56.1 1.0
SG A:CYS132 2.2 47.9 1.0
SG A:CYS124 2.3 46.0 1.0
SG A:CYS138 2.3 48.2 1.0
CD2 A:HIS142 3.0 53.8 1.0
CE1 A:HIS142 3.0 57.8 1.0
CB A:CYS138 3.1 54.2 1.0
CB A:CYS132 3.1 47.1 1.0
CB A:CYS124 3.2 50.2 1.0
CG A:HIS142 4.1 52.3 1.0
ND1 A:HIS142 4.1 57.6 1.0
CA A:CYS138 4.5 60.1 1.0
CA A:CYS124 4.5 46.3 1.0
CA A:CYS132 4.6 45.9 1.0
CB A:TYR127 4.6 43.6 1.0
N A:TYR127 4.7 37.0 1.0
CB A:HIS140 4.7 56.8 1.0
O A:HOH440 4.8 60.5 1.0
O A:HIS140 4.8 59.8 1.0
CB A:TRP126 4.9 41.6 1.0

Zinc binding site 2 out of 2 in 7k95

Go back to Zinc Binding Sites List in 7k95
Zinc binding site 2 out of 2 in the Crystal Structure of Human CPSF30 in Complex with HFIP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human CPSF30 in Complex with HFIP1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:37.5
occ:1.00
NE2 A:HIS166 2.1 34.4 1.0
SG A:CYS156 2.2 40.3 1.0
SG A:CYS162 2.3 42.1 1.0
SG A:CYS148 2.4 35.5 1.0
CE1 A:HIS166 3.1 38.2 1.0
CD2 A:HIS166 3.1 33.0 1.0
CB A:CYS162 3.2 43.3 1.0
CB A:CYS156 3.2 37.6 1.0
CB A:CYS148 3.2 35.0 1.0
O A:HOH434 3.9 45.3 1.0
O A:HOH443 4.1 57.6 1.0
ND1 A:HIS166 4.2 38.2 1.0
CG A:HIS166 4.2 35.1 1.0
O A:HOH441 4.5 51.3 1.0
CA A:CYS162 4.5 48.0 1.0
CA A:CYS148 4.6 34.5 1.0
CA A:CYS156 4.6 38.1 1.0
CB A:GLU158 4.6 53.6 1.0
CB A:TYR151 4.6 32.7 1.0
O A:PHE164 4.7 38.2 1.0
N A:TYR151 4.8 31.2 1.0
CG A:GLU158 4.9 53.7 1.0

Reference:

K.Hamilton, L.Tong. Molecular Mechanism For the Interaction Between Human CPSF30 and HFIP1. Genes Dev. 2020.
ISSN: ISSN 0890-9369
PubMed: 33122294
DOI: 10.1101/GAD.343814.120
Page generated: Wed Dec 16 14:03:38 2020

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