Zinc in PDB 7fu5: Crystal Structure of Human Cyclic Gmp-Amp Synthase

All present enzymatic activity of Crystal Structure of Human Cyclic Gmp-Amp Synthase:
2.7.7.86;

The structure of Crystal Structure of Human Cyclic Gmp-Amp Synthase, PDB code: 7fu5 was solved by L.Leibrock, J.Benz, K.Groebke-Zbinden, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.67 / 2.18
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	219.993, 45.554, 89.978, 90, 111.38, 90
R / Rfree (%)	22.1 / 27.8

The structure of Crystal Structure of Human Cyclic Gmp-Amp Synthase also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Human Cyclic Gmp-Amp Synthase (pdb code 7fu5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Cyclic Gmp-Amp Synthase, PDB code: 7fu5:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Cyclic Gmp-Amp Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Cyclic Gmp-Amp Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:35.0 occ:1.00 NE2 A:HIS390 2.1 36.0 1.0 SG A:CYS396 2.3 35.8 1.0 SG A:CYS404 2.3 37.3 1.0 SG A:CYS397 2.3 43.0 1.0 CD2 A:HIS390 2.8 29.0 1.0 CB A:CYS404 3.0 25.0 1.0 CE1 A:HIS390 3.2 44.8 1.0 CB A:CYS397 3.6 26.6 1.0 O A:HOH752 3.6 30.6 1.0 CB A:CYS396 3.7 30.4 1.0 N A:CYS404 3.9 38.4 1.0 N A:CYS397 3.9 36.8 1.0 CA A:CYS404 3.9 41.7 1.0 C A:CYS396 4.0 35.0 1.0 CG A:HIS390 4.1 30.9 1.0 ND1 A:HIS390 4.2 35.2 1.0 NH1 A:ARG406 4.2 29.2 1.0 CA A:CYS397 4.3 36.5 1.0 C A:CYS404 4.3 35.5 1.0 CA A:CYS396 4.4 33.5 1.0 O A:CYS396 4.4 35.6 1.0 O A:HOH735 4.5 34.1 1.0 O A:CYS404 4.6 36.5 1.0 O A:GLU402 4.8 47.9 1.0 N A:CYS405 5.0 29.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Cyclic Gmp-Amp Synthase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Cyclic Gmp-Amp Synthase within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:41.3 occ:1.00 NE2 B:HIS390 2.1 32.3 1.0 SG B:CYS397 2.3 37.5 1.0 SG B:CYS396 2.3 33.9 1.0 SG B:CYS404 2.3 33.4 1.0 CD2 B:HIS390 2.9 27.5 1.0 CE1 B:HIS390 3.2 33.7 1.0 CB B:CYS404 3.2 35.9 1.0 O B:HOH740 3.5 33.8 1.0 CB B:CYS397 3.5 34.3 1.0 CB B:CYS396 3.7 31.4 1.0 N B:CYS397 3.9 35.0 1.0 C B:CYS396 3.9 36.1 1.0 N B:CYS404 4.0 41.4 1.0 CG B:HIS390 4.1 25.1 1.0 CA B:CYS404 4.1 43.8 1.0 ND1 B:HIS390 4.2 26.5 1.0 NH1 B:ARG406 4.2 29.7 1.0 O B:CYS396 4.2 37.8 1.0 CA B:CYS397 4.3 35.2 1.0 CA B:CYS396 4.4 32.7 1.0 C B:CYS404 4.4 36.9 1.0 O B:CYS404 4.5 44.2 1.0 O B:GLU402 4.7 49.2 1.0

K.Groebke-Zbinden, A.Vandemeulebroucke, M.Hilbert, M.G.Rudolph. Crystal Structure of A Human Cyclic Gmp-Amp Synthase Complex To Be Published.