Zinc in PDB 7f9c: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f9c was solved by N.Malhotra, Y.Manickam, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.29 / 2.20
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	70.59, 91.66, 83.38, 90, 110.28, 90
R / Rfree (%)	18.8 / 25.3

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 also contains other interesting chemical elements:

Chlorine	(Cl)	4 atoms
Fluorine	(F)	2 atoms
Calcium	(Ca)	7 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 (pdb code 7f9c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96, PDB code: 7f9c:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:54.6 occ:0.77 SG A:CYS1448 2.3 65.2 1.0 SG A:CYS1497 2.4 67.4 1.0 SG A:CYS1453 2.4 65.0 1.0 SG A:CYS1495 2.5 67.2 1.0 CB A:CYS1497 2.8 61.9 1.0 CB A:CYS1453 3.2 69.8 1.0 CB A:CYS1448 3.2 72.0 1.0 CB A:CYS1495 3.4 65.2 1.0 N A:CYS1497 3.8 72.7 1.0 CA A:CYS1497 3.9 69.7 1.0 N A:CYS1448 3.9 67.3 1.0 CA A:CYS1448 4.2 69.7 1.0 CE1 A:PHE1447 4.4 64.5 1.0 CD1 A:PHE1447 4.4 59.9 1.0 OD1 A:ASN1500 4.5 71.3 1.0 CA A:CYS1453 4.7 61.8 1.0 CA A:CYS1495 4.8 66.2 1.0 C A:CYS1497 4.9 73.0 1.0 N A:VAL1496 4.9 69.4 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L96 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1902 b:55.6 occ:0.83 SG B:CYS1453 2.1 66.9 1.0 SG B:CYS1495 2.2 62.5 1.0 SG B:CYS1448 2.2 70.3 1.0 SG B:CYS1497 2.5 70.6 1.0 CB B:CYS1453 3.1 58.1 1.0 CB B:CYS1495 3.1 56.6 1.0 CB B:CYS1497 3.2 57.4 1.0 CB B:CYS1448 3.3 63.6 1.0 N B:CYS1448 3.9 58.0 1.0 CA B:CYS1448 4.2 62.2 1.0 N B:CYS1497 4.2 65.5 1.0 CE1 B:PHE1447 4.3 58.2 1.0 CD1 B:PHE1447 4.3 55.6 1.0 CA B:CYS1497 4.3 66.7 1.0 CA B:CYS1453 4.5 56.5 1.0 CA B:CYS1495 4.6 63.3 1.0 ND2 B:ASN1500 4.6 64.3 1.0 C B:CYS1495 4.8 64.4 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.