Zinc in PDB 7f9a: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97, PDB code: 7f9a was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.93 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.74, 105.92, 145.38, 90, 90, 90
R / Rfree (%)	19.5 / 24.2

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97 also contains other interesting chemical elements:

Calcium	(Ca)	10 atoms
Fluorine	(F)	2 atoms
Chlorine	(Cl)	3 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97 (pdb code 7f9a). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97, PDB code: 7f9a:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:48.1 occ:0.75 SG A:CYS1448 2.2 63.1 1.0 SG A:CYS1453 2.2 62.6 1.0 SG A:CYS1497 2.3 67.3 1.0 SG A:CYS1495 2.4 61.1 1.0 CB A:CYS1497 3.0 61.5 1.0 CB A:CYS1453 3.2 61.8 1.0 CB A:CYS1448 3.2 47.7 1.0 CB A:CYS1495 3.4 64.7 1.0 N A:CYS1497 4.0 61.2 1.0 N A:CYS1448 4.0 46.0 1.0 CA A:CYS1497 4.1 59.4 1.0 CA A:CYS1448 4.2 47.3 1.0 CE1 A:PHE1447 4.3 50.5 1.0 OD1 A:ASN1500 4.3 62.6 1.0 CD1 A:PHE1447 4.3 49.6 1.0 NZ A:LYS1499 4.5 84.8 1.0 CA A:CYS1453 4.6 58.0 1.0 CA A:CYS1495 4.8 53.0 1.0 CB A:ASN1500 4.9 63.7 1.0 CG A:ASN1500 5.0 62.1 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L97 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1902 b:79.8 occ:0.67 SG B:CYS1448 2.3 96.4 1.0 SG B:CYS1495 2.3 84.4 0.7 SG B:CYS1453 2.4 85.5 0.8 SG B:CYS1497 2.7 120.2 1.0 CB B:CYS1448 3.1 94.0 1.0 CB B:CYS1453 3.2 78.8 1.0 CB B:CYS1495 3.3 74.4 0.9 CB B:CYS1497 3.3 117.2 1.0 N B:CYS1448 3.8 73.7 1.0 CA B:CYS1448 4.1 84.1 1.0 N B:CYS1497 4.2 122.0 1.0 CE1 B:PHE1447 4.3 74.5 1.0 CD1 B:PHE1447 4.3 76.9 1.0 CA B:CYS1497 4.4 121.0 1.0 CA B:CYS1495 4.7 84.0 1.0 CA B:CYS1453 4.7 84.5 1.0 C B:CYS1495 4.9 89.5 1.0 C B:CYS1448 4.9 83.0 1.0 N B:VAL1496 4.9 100.2 1.0 C B:PHE1447 5.0 78.0 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.