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Zinc in PDB 7egq: Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading

Enzymatic activity of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading

All present enzymatic activity of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading:
2.7.7.48; 3.6.4.12; 3.6.4.13;

Other elements in 7egq:

The structure of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms

Zinc Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 26;

Binding sites:

The binding sites of Zinc atom in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading (pdb code 7egq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 26 binding sites of Zinc where determined in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading, PDB code: 7egq:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 26 in 7egq

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Zinc binding site 1 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1001

b:83.9
occ:1.00
 ND1 A:HIS295 2.1 52.9 1.0
CE1 A:HIS295 2.3 52.9 1.0
SG A:CYS310 2.3 49.6 1.0
SG A:CYS301 2.3 55.7 1.0
SG A:CYS306 2.3 53.3 1.0
O A:CYS306 3.2 53.3 1.0
CG A:HIS295 3.4 52.9 1.0
CB A:CYS306 3.4 53.3 1.0
NE2 A:HIS295 3.6 52.9 1.0
CB A:CYS301 3.6 55.7 1.0
C A:CYS306 3.7 53.3 1.0
CB A:CYS310 3.7 49.6 1.0
CA A:CYS301 3.9 55.7 1.0
CA A:CYS306 4.0 53.3 1.0
CD2 A:HIS295 4.1 52.9 1.0
CB A:HIS295 4.2 52.9 1.0
N A:HIS295 4.4 52.9 1.0
N A:ILE307 4.5 49.3 1.0
N A:CYS310 4.8 49.6 1.0
N A:CYS301 4.8 55.7 1.0
N A:LEU302 4.8 54.9 1.0
CA A:CYS310 4.9 49.6 1.0
CA A:HIS295 4.9 52.9 1.0
C A:CYS301 5.0 55.7 1.0

Zinc binding site 2 out of 26 in 7egq

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Zinc binding site 2 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1002

b:87.9
occ:1.00
 CE1 A:HIS642 1.9 53.5 1.0
ND1 A:HIS642 2.0 53.5 1.0
SG A:CYS487 2.3 51.8 1.0
SG A:CYS646 2.3 61.4 1.0
SG A:CYS645 2.3 57.9 1.0
NE2 A:HIS642 3.1 53.5 1.0
CG A:HIS642 3.2 53.5 1.0
CB A:CYS645 3.5 57.9 1.0
CB A:CYS646 3.5 61.4 1.0
CE1 A:PHE571 3.6 43.8 1.0
N A:CYS646 3.7 61.4 1.0
CD2 A:HIS642 3.7 53.5 1.0
CB A:CYS487 3.8 51.8 1.0
N A:CYS487 3.9 51.8 1.0
CA A:CYS646 4.1 61.4 1.0
CD1 A:PHE571 4.2 43.8 1.0
CB A:HIS642 4.2 53.5 1.0
C A:CYS645 4.2 57.9 1.0
CA A:CYS487 4.3 51.8 1.0
CA A:CYS645 4.5 57.9 1.0
NZ A:LYS532 4.5 40.9 1.0
CE A:LYS532 4.6 40.9 1.0
CZ A:PHE571 4.7 43.8 1.0
C A:GLY486 4.8 50.2 1.0
O A:CYS645 5.0 57.9 1.0

Zinc binding site 3 out of 26 in 7egq

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Zinc binding site 3 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn701

b:305.2
occ:1.00
 ND1 E:HIS39 2.1 244.1 1.0
NE2 E:HIS33 2.1 250.5 1.0
CB E:CYS19 2.2 249.5 1.0
SG E:CYS16 2.3 243.6 1.0
SG E:CYS19 2.3 249.5 1.0
CE1 E:HIS39 2.4 244.1 1.0
CD2 E:HIS33 3.0 250.5 1.0
CE1 E:HIS33 3.0 250.5 1.0
CG E:HIS39 3.1 244.1 1.0
CZ E:PHE106 3.2 252.9 1.0
CA E:CYS19 3.3 249.5 1.0
NE2 E:HIS39 3.5 244.1 1.0
CB E:CYS16 3.6 243.6 1.0
CD2 E:HIS39 3.8 244.1 1.0
CE1 E:PHE106 3.8 252.9 1.0
N E:CYS19 3.9 249.5 1.0
CB E:HIS39 3.9 244.1 1.0
ND1 E:HIS33 4.1 250.5 1.0
CG E:HIS33 4.1 250.5 1.0
CB E:ALA110 4.2 258.3 1.0
CE2 E:PHE106 4.3 252.9 1.0
C E:CYS19 4.6 249.5 1.0
O E:CYS16 4.9 243.6 1.0
CD E:PRO23 4.9 240.6 1.0
CA E:CYS16 4.9 243.6 1.0
C E:ALA18 4.9 242.2 1.0

Zinc binding site 4 out of 26 in 7egq

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Zinc binding site 4 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn702

b:283.5
occ:1.00
 SG E:CYS26 2.3 246.3 1.0
SG E:CYS8 2.3 250.7 1.0
SG E:CYS5 2.3 247.8 1.0
SG E:CYS29 2.3 246.7 1.0
CB E:CYS8 2.8 250.7 1.0
CB E:CYS29 3.0 246.7 1.0
CB E:CYS26 3.4 246.3 1.0
CB E:CYS5 3.6 247.8 1.0
N E:GLY99 3.7 239.8 1.0
N E:CYS8 3.8 250.7 1.0
N E:SER100 3.9 234.9 1.0
N E:CYS26 3.9 246.3 1.0
CA E:CYS8 3.9 250.7 1.0
CA E:GLY99 3.9 239.8 1.0
CA E:CYS29 4.2 246.7 1.0
N E:CYS29 4.2 246.7 1.0
CA E:CYS26 4.2 246.3 1.0
C E:GLY99 4.3 239.8 1.0
OG E:SER10 4.4 244.2 1.0
CB E:LEU7 4.5 251.2 1.0
C E:LEU7 4.7 251.2 1.0
CB E:SER100 4.8 234.9 1.0
O E:CYS26 4.8 246.3 1.0
C E:VAL98 4.8 234.9 1.0
CD2 E:LEU25 4.9 245.3 1.0
C E:CYS26 4.9 246.3 1.0
CA E:SER100 4.9 234.9 1.0
C E:LEU25 5.0 245.3 1.0
CA E:CYS5 5.0 247.8 1.0
CB E:VAL98 5.0 234.9 1.0
N E:VAL98 5.0 234.9 1.0

Zinc binding site 5 out of 26 in 7egq

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Zinc binding site 5 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn703

b:281.4
occ:1.00
 ND1 E:HIS75 2.1 232.2 1.0
SG E:CYS55 2.3 243.0 1.0
SG E:CYS72 2.3 232.4 1.0
SG E:CYS50 2.3 233.7 1.0
CB E:CYS72 2.3 232.4 1.0
CE1 E:HIS75 2.8 232.2 1.0
CB E:CYS50 3.0 233.7 1.0
CB E:CYS55 3.2 243.0 1.0
N E:CYS72 3.3 232.4 1.0
CG E:HIS75 3.3 232.2 1.0
CA E:CYS72 3.4 232.4 1.0
CG2 E:VAL57 3.8 233.4 1.0
CB E:HIS75 3.8 232.2 1.0
NE2 E:HIS75 4.0 232.2 1.0
CD2 E:HIS75 4.3 232.2 1.0
C E:CYS72 4.4 232.4 1.0
C E:TYR71 4.5 220.8 1.0
CA E:CYS50 4.5 233.7 1.0
CA E:CYS55 4.5 243.0 1.0
CB E:VAL57 4.6 233.4 1.0
CB E:ALA52 4.7 236.9 1.0
N E:HIS75 4.8 232.2 1.0
O E:CYS55 4.9 243.0 1.0
C E:CYS55 5.0 243.0 1.0
CA E:HIS75 5.0 232.2 1.0
CA E:TYR71 5.0 220.8 1.0
N E:LYS73 5.0 227.4 1.0

Zinc binding site 6 out of 26 in 7egq

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Zinc binding site 6 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn200

b:105.0
occ:1.00
 CB H:CYS90 1.9 91.2 1.0
NE2 H:HIS83 2.1 80.3 1.0
SG H:CYS90 2.3 91.2 1.0
SG H:CYS74 2.3 79.7 1.0
SG H:CYS77 2.3 79.7 1.0
CD2 H:HIS83 2.9 80.3 1.0
CB H:CYS74 3.1 79.7 1.0
CE1 H:HIS83 3.1 80.3 1.0
CB H:CYS77 3.3 79.7 1.0
CA H:CYS90 3.3 91.2 1.0
N H:CYS77 3.9 79.7 1.0
CA H:CYS77 4.1 79.7 1.0
N H:CYS90 4.1 91.2 1.0
CG H:HIS83 4.1 80.3 1.0
ND1 H:HIS83 4.1 80.3 1.0
C H:CYS90 4.3 91.2 1.0
CA H:CYS74 4.5 79.7 1.0
CB H:TYR76 4.6 79.7 1.0
C H:TYR76 4.8 79.7 1.0
O H:CYS74 4.8 79.7 1.0
N H:ASP91 4.8 90.9 1.0
C H:CYS74 4.9 79.7 1.0

Zinc binding site 7 out of 26 in 7egq

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Zinc binding site 7 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn201

b:211.0
occ:1.00
 N H:CYS120 2.2 169.7 1.0
SG H:CYS120 2.3 169.7 1.0
SG H:CYS130 2.3 202.4 1.0
SG H:CYS117 2.3 159.2 1.0
CB H:CYS120 2.4 169.7 1.0
CA H:CYS120 2.8 169.7 1.0
CB H:CYS117 3.2 159.2 1.0
C H:VAL119 3.3 179.9 1.0
CB H:VAL119 3.4 179.9 1.0
CA H:VAL119 3.7 179.9 1.0
N H:VAL119 3.8 179.9 1.0
C H:CYS120 3.9 169.7 1.0
N H:CYS130 4.0 202.4 1.0
CB H:CYS130 4.0 202.4 1.0
CG1 H:VAL119 4.0 179.9 1.0
N H:GLY121 4.1 161.7 1.0
OG H:SER129 4.2 198.2 1.0
N H:SER129 4.2 198.2 1.0
O H:CYS117 4.3 159.2 1.0
C H:CYS117 4.3 159.2 1.0
CA H:CYS117 4.4 159.2 1.0
O H:VAL119 4.4 179.9 1.0
CB H:CYS128 4.5 171.6 1.0
CG2 H:VAL119 4.6 179.9 1.0
CA H:CYS130 4.6 202.4 1.0
CA H:CYS128 4.7 171.6 1.0
C H:THR118 4.9 171.3 1.0
CB H:SER129 4.9 198.2 1.0
C H:CYS128 4.9 171.6 1.0
CA H:SER129 4.9 198.2 1.0
O H:CYS120 4.9 169.7 1.0
N H:THR118 4.9 171.3 1.0
C H:SER129 4.9 198.2 1.0

Zinc binding site 8 out of 26 in 7egq

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Zinc binding site 8 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn600

b:72.3
occ:1.00
 SG K:CYS226 2.2 79.7 1.0
SG K:CYS210 2.3 79.7 1.0
ND1 K:HIS229 2.3 79.7 1.0
CB K:HIS229 2.8 79.7 1.0
CG K:HIS229 2.9 79.7 1.0
SG K:CYS207 2.9 79.7 1.0
N K:CYS226 3.0 79.7 1.0
CB K:CYS226 3.0 79.7 1.0
N K:HIS229 3.3 79.7 1.0
CB K:CYS210 3.4 79.7 1.0
CA K:CYS226 3.5 79.7 1.0
CE1 K:HIS229 3.5 79.7 1.0
CA K:HIS229 3.5 79.7 1.0
C K:CYS226 4.1 79.7 1.0
C K:HIS229 4.1 79.7 1.0
C K:ALA225 4.1 79.7 1.0
O K:HIS229 4.1 79.7 1.0
CD2 K:HIS229 4.1 79.7 1.0
CB K:CYS207 4.2 79.7 1.0
CA K:ALA225 4.3 79.7 1.0
O K:CYS208 4.4 79.7 1.0
NE2 K:HIS229 4.4 79.7 1.0
O K:CYS226 4.5 79.7 1.0
C K:HIS228 4.5 79.7 1.0
CB K:ALA225 4.5 79.7 1.0
N K:HIS228 4.6 79.7 1.0
N K:TRP227 4.7 79.7 1.0
CA K:CYS210 4.8 79.7 1.0
CB K:HIS228 4.9 46.8 1.0
CA K:HIS228 4.9 79.7 1.0
N K:CYS210 4.9 79.7 1.0

Zinc binding site 9 out of 26 in 7egq

Go back to Zinc Binding Sites List in 7egq
Zinc binding site 9 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn601

b:89.4
occ:1.00
 CE1 K:HIS257 1.1 79.7 1.0
ND1 K:HIS264 2.0 79.7 1.0
NE2 K:HIS257 2.0 79.7 1.0
ND1 K:HIS257 2.3 79.7 1.0
SG K:CYS261 2.3 79.7 1.0
SG K:CYS279 2.3 79.7 1.0
CE1 K:HIS264 2.4 79.7 1.0
CB K:CYS261 2.5 79.7 1.0
CD2 K:HIS257 3.2 79.7 1.0
CG K:HIS257 3.3 79.7 1.0
CG K:HIS264 3.3 79.7 1.0
CB K:CYS279 3.5 79.7 1.0
NE2 K:HIS264 3.7 79.7 1.0
CA K:CYS261 3.9 79.7 1.0
CB K:HIS264 4.1 79.7 1.0
CD2 K:HIS264 4.1 79.7 1.0
O K:CYS261 4.2 79.7 1.0
C K:CYS261 4.4 79.7 1.0
N K:CYS261 4.5 79.7 1.0
CB K:HIS257 4.7 79.7 1.0
N K:HIS264 4.7 79.7 1.0
O K:HIS257 4.8 79.7 1.0
CA K:CYS279 4.8 79.7 1.0
CB K:CYS414 5.0 79.7 1.0
CA K:MET276 5.0 79.7 1.0

Zinc binding site 10 out of 26 in 7egq

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Zinc binding site 10 out of 26 in the Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Co-Transcriptional Capping Machineries in Sars-Cov-2 Rtc: Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Polymerase Reveals Mechanisms For Capping and Proofreading within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn602

b:128.6
occ:1.00
 CE1 K:HIS487 1.4 87.5 1.0
ND1 K:HIS487 2.1 87.5 1.0
SG K:CYS452 2.3 108.1 1.0
NE2 K:HIS487 2.6 87.5 1.0
SG K:CYS484 2.7 93.6 1.0
CB K:CYS452 3.2 108.1 1.0
CG K:HIS487 3.4 87.5 1.0
CB K:CYS484 3.4 93.6 1.0
N K:CYS477 3.4 94.5 1.0
CD2 K:HIS487 3.6 87.5 1.0
CB K:CYS477 3.6 94.5 1.0
O K:CYS477 3.7 94.5 1.0
CA K:CYS452 3.8 108.1 1.0
O K:PRO451 3.8 101.7 1.0
CA K:CYS477 3.9 94.5 1.0
O K:THR475 4.3 80.6 1.0
C K:CYS477 4.3 94.5 1.0
OG1 K:THR475 4.3 80.6 1.0
C K:ARG476 4.3 87.5 1.0
C K:PRO451 4.4 101.7 1.0
N K:CYS452 4.4 108.1 1.0
SG K:CYS477 4.5 94.5 1.0
O K:ARG476 4.6 87.5 1.0
CB K:HIS487 4.6 87.5 1.0
O K:SER450 4.8 96.8 1.0
CA K:CYS484 4.9 93.6 1.0
C K:CYS452 5.0 108.1 1.0

Reference:

L.Yan, Y.Yang, M.Li, Y.Zhang, L.Zheng, J.Ge, Y.C.Huang, Z.Liu, T.Wang, S.Gao, R.Zhang, Y.Y.Huang, L.W.Guddat, Y.Gao, Z.Rao, Z.Lou. Coupling of N7-Methyltransferase and 3'-5' Exoribonuclease with Sars-Cov-2 Polymerase Reveals Mechanisms For Capping and Proofreading. Cell V. 184 3474 2021.
ISSN: ISSN 1097-4172
PubMed: 34143953
DOI: 10.1016/J.CELL.2021.05.033
Page generated: Tue Oct 29 19:46:49 2024

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