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Zinc in PDB 7ef8: Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I)

Enzymatic activity of Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I)

All present enzymatic activity of Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I):
3.2.2.31;

Protein crystallography data

The structure of Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I), PDB code: 7ef8 was solved by T.Nakamura, Y.Nakabeppu, Y.Yamagata, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.89 / 2.45
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 74.274, 107.236, 156.432, 90, 90, 90
R / Rfree (%) 19.8 / 22.1

Other elements in 7ef8:

The structure of Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I) also contains other interesting chemical elements:

Iron (Fe) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I) (pdb code 7ef8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I), PDB code: 7ef8:

Zinc binding site 1 out of 1 in 7ef8

Go back to Zinc Binding Sites List in 7ef8
Zinc binding site 1 out of 1 in the Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mouse Mutyh in Complex with Dna Containing Ap Site Analogue:8-Oxog (Form I) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:126.7
occ:1.00
 SG A:CYS310 2.4 111.2 1.0
SG A:CYS307 2.4 141.3 1.0
NE2 A:HIS56 2.6 122.7 1.0
SG A:CYS300 3.0 141.4 1.0
CD2 A:HIS56 3.3 122.3 1.0
CB A:CYS307 3.3 148.8 1.0
CB A:CYS310 3.3 119.5 1.0
N A:CYS310 3.4 122.0 1.0
CE1 A:HIS56 3.6 117.7 1.0
CA A:CYS310 3.9 120.7 1.0
C A:LEU309 4.2 117.5 1.0
N A:LEU309 4.3 128.1 1.0
CB A:CYS300 4.4 142.1 1.0
CG A:HIS56 4.5 116.8 1.0
CB A:LEU309 4.5 112.7 1.0
CA A:LEU309 4.5 118.7 1.0
ND1 A:HIS56 4.6 114.8 1.0
CA A:CYS307 4.8 152.1 1.0
N A:GLN308 4.8 145.3 1.0

Reference:

T.Nakamura, K.Okabe, S.Hirayama, M.Chirifu, S.Ikemizu, H.Morioka, Y.Nakabeppu, Y.Yamagata. Structure of the Mammalian Adenine Dna Glycosylase Mutyh: Insights Into the Base Excision Repair Pathway and Cancer. Nucleic Acids Res. 2021.
ISSN: ESSN 1362-4962
DOI: 10.1093/NAR/GKAB492
Page generated: Tue Oct 29 19:43:25 2024

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