Zinc in PDB 7dn3: Structure of Human Rna Polymerase III Elongation Complex
Enzymatic activity of Structure of Human Rna Polymerase III Elongation Complex
All present enzymatic activity of Structure of Human Rna Polymerase III Elongation Complex:
2.7.7.6;
Other elements in 7dn3:
The structure of Structure of Human Rna Polymerase III Elongation Complex also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Human Rna Polymerase III Elongation Complex
(pdb code 7dn3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the
Structure of Human Rna Polymerase III Elongation Complex, PDB code: 7dn3:
Jump to Zinc binding site number:
1;
2;
3;
4;
5;
6;
Zinc binding site 1 out
of 6 in 7dn3
Go back to
Zinc Binding Sites List in 7dn3
Zinc binding site 1 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1902
b:109.9
occ:1.00
|
NE2
|
A:HIS82
|
2.1
|
84.0
|
1.0
|
SG
|
A:CYS69
|
2.4
|
96.0
|
1.0
|
SG
|
A:CYS79
|
2.4
|
88.7
|
1.0
|
CB
|
A:CYS72
|
2.4
|
94.5
|
1.0
|
SG
|
A:CYS72
|
2.5
|
94.5
|
1.0
|
CE1
|
A:HIS82
|
2.9
|
84.0
|
1.0
|
CD2
|
A:HIS82
|
3.1
|
84.0
|
1.0
|
N
|
A:CYS72
|
3.2
|
94.5
|
1.0
|
CA
|
A:CYS72
|
3.4
|
94.5
|
1.0
|
CB
|
A:CYS69
|
4.0
|
96.0
|
1.0
|
ND1
|
A:HIS82
|
4.0
|
84.0
|
1.0
|
CB
|
A:CYS79
|
4.0
|
88.7
|
1.0
|
CG2
|
A:THR71
|
4.1
|
92.6
|
1.0
|
CG
|
A:HIS82
|
4.2
|
84.0
|
1.0
|
C
|
A:THR71
|
4.2
|
92.6
|
1.0
|
C
|
A:CYS72
|
4.3
|
94.5
|
1.0
|
O
|
A:CYS72
|
4.8
|
94.5
|
1.0
|
O
|
A:LEU80
|
4.8
|
84.7
|
1.0
|
O
|
A:THR71
|
4.9
|
92.6
|
1.0
|
N
|
A:THR71
|
4.9
|
92.6
|
1.0
|
|
Zinc binding site 2 out
of 6 in 7dn3
Go back to
Zinc Binding Sites List in 7dn3
Zinc binding site 2 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Zn1903
b:140.3
occ:1.00
|
O
|
A:ALA161
|
2.1
|
117.2
|
1.0
|
C
|
A:ALA161
|
2.4
|
117.2
|
1.0
|
N
|
A:ALA161
|
2.4
|
117.2
|
1.0
|
CA
|
A:ALA161
|
2.5
|
117.2
|
1.0
|
SG
|
A:CYS159
|
2.6
|
121.4
|
1.0
|
CB
|
A:ALA161
|
2.7
|
117.2
|
1.0
|
SG
|
A:CYS156
|
2.7
|
118.4
|
1.0
|
C
|
A:GLY160
|
3.5
|
118.5
|
1.0
|
N
|
A:PHE162
|
3.5
|
113.6
|
1.0
|
SG
|
A:CYS109
|
3.5
|
104.6
|
1.0
|
OG1
|
A:THR111
|
3.5
|
104.6
|
1.0
|
CB
|
A:CYS156
|
3.8
|
118.4
|
1.0
|
OD1
|
A:ASN163
|
4.0
|
112.6
|
1.0
|
N
|
A:GLY160
|
4.0
|
118.5
|
1.0
|
ND2
|
A:ASN163
|
4.1
|
112.6
|
1.0
|
N
|
A:CYS156
|
4.1
|
118.4
|
1.0
|
CA
|
A:GLY160
|
4.2
|
118.5
|
1.0
|
O
|
A:GLY160
|
4.3
|
118.5
|
1.0
|
CB
|
A:CYS159
|
4.3
|
121.4
|
1.0
|
CG
|
A:ASN163
|
4.3
|
112.6
|
1.0
|
CA
|
A:PHE162
|
4.4
|
113.6
|
1.0
|
C
|
A:CYS159
|
4.4
|
121.4
|
1.0
|
CA
|
A:CYS156
|
4.6
|
118.4
|
1.0
|
C
|
A:PHE162
|
4.6
|
113.6
|
1.0
|
CB
|
A:CYS109
|
4.7
|
104.6
|
1.0
|
CB
|
A:THR111
|
4.9
|
104.6
|
1.0
|
CA
|
A:CYS159
|
4.9
|
121.4
|
1.0
|
O
|
A:CYS159
|
4.9
|
121.4
|
1.0
|
N
|
A:ASN163
|
5.0
|
112.6
|
1.0
|
|
Zinc binding site 3 out
of 6 in 7dn3
Go back to
Zinc Binding Sites List in 7dn3
Zinc binding site 3 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn1201
b:95.5
occ:1.00
|
SG
|
B:CYS1083
|
2.5
|
81.5
|
1.0
|
SG
|
B:CYS1080
|
2.5
|
81.6
|
1.0
|
O
|
B:TYR1094
|
2.9
|
85.8
|
1.0
|
SG
|
B:CYS1092
|
2.9
|
86.5
|
1.0
|
SG
|
B:CYS1095
|
3.0
|
88.1
|
1.0
|
CB
|
B:CYS1092
|
3.5
|
86.5
|
1.0
|
CB
|
B:CYS1080
|
3.7
|
81.6
|
1.0
|
C
|
B:TYR1094
|
3.9
|
85.8
|
1.0
|
O
|
B:GLN1082
|
4.1
|
83.6
|
1.0
|
CB
|
B:CYS1095
|
4.2
|
88.1
|
1.0
|
CB
|
B:CYS1083
|
4.3
|
81.5
|
1.0
|
CD2
|
B:TYR1094
|
4.3
|
85.8
|
1.0
|
O
|
B:CYS1095
|
4.3
|
88.1
|
1.0
|
CB
|
B:TYR1094
|
4.5
|
85.8
|
1.0
|
N
|
B:CYS1095
|
4.7
|
88.1
|
1.0
|
CA
|
B:CYS1095
|
4.8
|
88.1
|
1.0
|
O
|
B:CYS1092
|
4.8
|
86.5
|
1.0
|
CA
|
B:TYR1094
|
4.8
|
85.8
|
1.0
|
CA
|
B:CYS1092
|
4.8
|
86.5
|
1.0
|
O
|
B:CYS1083
|
4.8
|
81.5
|
1.0
|
C
|
B:CYS1095
|
4.9
|
88.1
|
1.0
|
C
|
B:CYS1092
|
4.9
|
86.5
|
1.0
|
C
|
B:GLN1082
|
4.9
|
83.6
|
1.0
|
CG
|
B:TYR1094
|
4.9
|
85.8
|
1.0
|
CG
|
B:GLN1082
|
5.0
|
83.6
|
1.0
|
N
|
B:TYR1094
|
5.0
|
85.8
|
1.0
|
|
Zinc binding site 4 out
of 6 in 7dn3
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Zinc Binding Sites List in 7dn3
Zinc binding site 4 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:Zn2000
b:30.0
occ:1.00
|
CD1
|
I:PHE23
|
2.5
|
130.2
|
1.0
|
SG
|
I:CYS5
|
2.7
|
122.0
|
1.0
|
SG
|
I:CYS25
|
2.9
|
125.3
|
1.0
|
O
|
I:ASN26
|
3.0
|
125.5
|
1.0
|
CE1
|
I:PHE23
|
3.2
|
130.2
|
1.0
|
SG
|
I:CYS8
|
3.4
|
117.7
|
1.0
|
CG
|
I:PHE23
|
3.4
|
130.2
|
1.0
|
CB
|
I:CYS5
|
3.6
|
122.0
|
1.0
|
CB
|
I:PHE23
|
3.8
|
130.2
|
1.0
|
CB
|
I:CYS28
|
4.0
|
130.3
|
1.0
|
C
|
I:ASN26
|
4.2
|
125.5
|
1.0
|
CZ
|
I:PHE23
|
4.4
|
130.2
|
1.0
|
CB
|
I:CYS8
|
4.4
|
117.7
|
1.0
|
N
|
I:CYS28
|
4.5
|
130.3
|
1.0
|
N
|
I:ASN26
|
4.5
|
125.5
|
1.0
|
CD2
|
I:PHE23
|
4.6
|
130.2
|
1.0
|
CB
|
I:CYS25
|
4.7
|
125.3
|
1.0
|
N
|
I:CYS8
|
4.8
|
117.7
|
1.0
|
CA
|
I:CYS28
|
4.8
|
130.3
|
1.0
|
CA
|
I:ASN26
|
4.9
|
125.5
|
1.0
|
C
|
I:CYS25
|
4.9
|
125.3
|
1.0
|
CA
|
I:CYS5
|
4.9
|
122.0
|
1.0
|
CE2
|
I:PHE23
|
4.9
|
130.2
|
1.0
|
C
|
I:THR27
|
4.9
|
127.2
|
1.0
|
CA
|
I:PHE23
|
5.0
|
130.2
|
1.0
|
|
Zinc binding site 5 out
of 6 in 7dn3
Go back to
Zinc Binding Sites List in 7dn3
Zinc binding site 5 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
L:Zn101
b:98.6
occ:1.00
|
CB
|
L:CYS22
|
2.5
|
85.9
|
1.0
|
CB
|
L:CYS39
|
2.7
|
98.0
|
1.0
|
SG
|
L:CYS39
|
2.8
|
98.0
|
1.0
|
SG
|
L:CYS19
|
2.9
|
81.3
|
1.0
|
CB
|
L:CYS19
|
3.0
|
81.3
|
1.0
|
SG
|
L:CYS22
|
3.3
|
85.9
|
1.0
|
CB
|
L:CYS36
|
3.5
|
93.2
|
1.0
|
CA
|
L:CYS22
|
3.8
|
85.9
|
1.0
|
O
|
L:ARG37
|
3.8
|
95.1
|
1.0
|
N
|
L:CYS22
|
3.9
|
85.9
|
1.0
|
SG
|
L:CYS36
|
3.9
|
93.2
|
1.0
|
CA
|
L:CYS39
|
4.0
|
98.0
|
1.0
|
OG1
|
L:THR24
|
4.2
|
83.6
|
1.0
|
N
|
L:CYS39
|
4.2
|
98.0
|
1.0
|
CA
|
L:CYS19
|
4.4
|
81.3
|
1.0
|
C
|
L:GLU38
|
4.6
|
97.9
|
1.0
|
O
|
L:GLU38
|
4.6
|
97.9
|
1.0
|
C
|
L:CYS22
|
4.6
|
85.9
|
1.0
|
N
|
L:GLY20
|
4.7
|
79.8
|
1.0
|
N
|
L:HIS23
|
4.8
|
83.8
|
1.0
|
CA
|
L:CYS36
|
4.9
|
93.2
|
1.0
|
C
|
L:ARG37
|
4.9
|
95.1
|
1.0
|
C
|
L:CYS39
|
5.0
|
98.0
|
1.0
|
|
Zinc binding site 6 out
of 6 in 7dn3
Go back to
Zinc Binding Sites List in 7dn3
Zinc binding site 6 out
of 6 in the Structure of Human Rna Polymerase III Elongation Complex
Mono view
Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Structure of Human Rna Polymerase III Elongation Complex within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:Zn2000
b:30.0
occ:1.00
|
SG
|
J:CYS45
|
2.2
|
54.9
|
1.0
|
CB
|
J:CYS10
|
2.6
|
57.9
|
1.0
|
SG
|
J:CYS7
|
2.6
|
54.0
|
1.0
|
SG
|
J:CYS44
|
2.7
|
57.1
|
1.0
|
SG
|
J:CYS10
|
2.9
|
57.9
|
1.0
|
N
|
J:CYS10
|
3.0
|
57.9
|
1.0
|
OG1
|
J:THR9
|
3.1
|
55.0
|
1.0
|
CB
|
J:CYS7
|
3.2
|
54.0
|
1.0
|
CA
|
J:CYS10
|
3.3
|
57.9
|
1.0
|
CB
|
J:CYS45
|
3.7
|
54.9
|
1.0
|
N
|
J:CYS45
|
3.8
|
54.9
|
1.0
|
N
|
J:GLY11
|
3.8
|
55.5
|
1.0
|
C
|
J:CYS10
|
4.0
|
57.9
|
1.0
|
CA
|
J:CYS45
|
4.1
|
54.9
|
1.0
|
C
|
J:THR9
|
4.2
|
55.0
|
1.0
|
CB
|
J:CYS44
|
4.2
|
57.1
|
1.0
|
C
|
J:CYS44
|
4.3
|
57.1
|
1.0
|
CD
|
J:ARG42
|
4.3
|
58.8
|
1.0
|
NH1
|
J:ARG42
|
4.4
|
58.8
|
1.0
|
CB
|
J:THR9
|
4.4
|
55.0
|
1.0
|
N
|
J:LYS12
|
4.5
|
54.1
|
1.0
|
CA
|
J:CYS7
|
4.6
|
54.0
|
1.0
|
CG
|
J:ARG42
|
4.6
|
58.8
|
1.0
|
CA
|
J:THR9
|
4.6
|
55.0
|
1.0
|
N
|
J:THR9
|
4.7
|
55.0
|
1.0
|
O
|
J:CYS44
|
4.7
|
57.1
|
1.0
|
CA
|
J:CYS44
|
4.9
|
57.1
|
1.0
|
CB
|
J:LYS12
|
4.9
|
54.1
|
1.0
|
C
|
J:CYS7
|
5.0
|
54.0
|
1.0
|
|
Reference:
L.Li,
Z.Yu,
D.Zhao,
Y.Ren,
H.Hou,
Y.Xu.
Structure of Human Rna Polymerase III Elongation Complex. Cell Res. 2021.
ISSN: ISSN 1001-0602
PubMed: 33674783
DOI: 10.1038/S41422-021-00472-2
Page generated: Tue Oct 29 19:06:25 2024
|