Zinc in PDB 7cun: The Structure of Human Integrator-PP2A Complex

Enzymatic activity of The Structure of Human Integrator-PP2A Complex

All present enzymatic activity of The Structure of Human Integrator-PP2A Complex:
3.1.3.16;

Other elements in 7cun:

The structure of The Structure of Human Integrator-PP2A Complex also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the The Structure of Human Integrator-PP2A Complex (pdb code 7cun). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Structure of Human Integrator-PP2A Complex, PDB code: 7cun:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7cun

Go back to Zinc Binding Sites List in 7cun
Zinc binding site 1 out of 2 in the The Structure of Human Integrator-PP2A Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure of Human Integrator-PP2A Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn701

b:0.0
occ:1.00
OD2 K:ASP184 2.2 0.2 1.0
OD2 K:ASP78 2.2 0.7 1.0
CD2 K:HIS79 2.4 0.9 1.0
NE2 K:HIS79 2.4 0.9 1.0
CE1 K:HIS420 3.0 0.6 1.0
CG K:ASP184 3.0 0.2 1.0
OD1 K:ASP184 3.1 0.2 1.0
CG K:ASP78 3.3 0.7 1.0
CE1 K:HIS398 3.4 0.4 1.0
NE2 K:HIS420 3.5 0.6 1.0
ND1 K:HIS420 3.5 0.6 1.0
ZN K:ZN702 3.6 0.2 1.0
CE1 K:HIS79 3.7 0.9 1.0
CG K:HIS79 3.7 0.9 1.0
CE1 K:HIS74 3.9 0.7 1.0
OD1 K:ASP78 4.0 0.7 1.0
ND1 K:HIS398 4.1 0.4 1.0
OE1 K:GLU209 4.2 0.2 1.0
CD2 K:HIS420 4.2 0.6 1.0
CB K:ASP78 4.2 0.7 1.0
NE2 K:HIS74 4.2 0.7 1.0
CG K:HIS420 4.2 0.6 1.0
ND1 K:HIS79 4.3 0.9 1.0
CB K:ASP184 4.4 0.2 1.0
NE2 K:HIS398 4.5 0.4 1.0
O K:ASP78 4.8 0.7 1.0
CB K:HIS79 4.8 0.9 1.0
C K:ASP78 4.9 0.7 1.0

Zinc binding site 2 out of 2 in 7cun

Go back to Zinc Binding Sites List in 7cun
Zinc binding site 2 out of 2 in the The Structure of Human Integrator-PP2A Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Structure of Human Integrator-PP2A Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Zn702

b:0.2
occ:1.00
OD2 K:ASP184 2.4 0.2 1.0
NE2 K:HIS163 2.5 0.0 1.0
NE2 K:HIS74 2.5 0.7 1.0
CE1 K:HIS74 2.6 0.7 1.0
NE2 K:HIS76 2.9 0.4 1.0
CD2 K:HIS74 3.1 0.7 1.0
CE1 K:HIS76 3.1 0.4 1.0
OD2 K:ASP78 3.2 0.7 1.0
ND1 K:HIS74 3.2 0.7 1.0
CD2 K:HIS163 3.3 0.0 1.0
CG K:ASP184 3.4 0.2 1.0
CG K:HIS74 3.5 0.7 1.0
CE1 K:HIS163 3.6 0.0 1.0
ZN K:ZN701 3.6 0.0 1.0
CB K:ASP184 3.7 0.2 1.0
OD1 K:ASP78 3.7 0.7 1.0
CG K:ASP78 3.8 0.7 1.0
CE1 K:HIS398 3.9 0.4 1.0
CD2 K:HIS76 4.1 0.4 1.0
ND1 K:HIS76 4.3 0.4 1.0
NE2 K:HIS398 4.3 0.4 1.0
CG K:HIS163 4.5 0.0 1.0
OD1 K:ASP184 4.5 0.2 1.0
CD2 K:HIS79 4.6 0.9 1.0
ND1 K:HIS163 4.6 0.0 1.0
ND1 K:HIS398 4.6 0.4 1.0
CB K:HIS74 4.7 0.7 1.0
CG1 K:VAL164 4.8 0.5 1.0
CG K:HIS76 4.8 0.4 1.0

Reference:

H.Zheng, Y.Qi, S.Hu, X.Cao, C.Xu, Z.Yin, X.Chen, Y.Li, W.Liu, J.Li, J.Wang, G.Wei, K.Liang, F.X.Chen, Y.Xu. Identification of Integrator-PP2A Complex (Intac), An Rna Polymerase II Phosphatase. Science V. 370 2020.
ISSN: ESSN 1095-9203
PubMed: 33243860
DOI: 10.1126/SCIENCE.ABB5872
Page generated: Wed Dec 16 13:42:45 2020

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