Zinc in PDB 7ctt: Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State.

All present enzymatic activity of Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State.:
2.7.7.48;

The structure of Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State. also contains other interesting chemical elements:

Fluorine	(F)	1 atom
Magnesium	(Mg)	1 atom

The binding sites of Zinc atom in the Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State. (pdb code 7ctt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State., PDB code: 7ctt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:71.3 occ:1.00 SG A:CYS306 2.3 47.2 1.0 SG A:CYS310 2.3 45.1 1.0 SG A:CYS301 2.3 50.0 1.0 ND1 A:HIS295 2.4 48.2 1.0 CB A:CYS301 3.0 50.0 1.0 CE1 A:HIS295 3.0 48.2 1.0 CA A:CYS301 3.2 50.0 1.0 O A:CYS306 3.3 47.2 1.0 CG A:HIS295 3.4 48.2 1.0 CB A:CYS306 3.6 47.2 1.0 CB A:CYS310 3.6 45.1 1.0 C A:CYS306 3.7 47.2 1.0 CB A:HIS295 4.0 48.2 1.0 N A:CYS301 4.0 50.0 1.0 CA A:CYS306 4.1 47.2 1.0 NE2 A:HIS295 4.2 48.2 1.0 O A:ASN300 4.2 48.1 1.0 C A:CYS301 4.4 50.0 1.0 N A:LEU302 4.4 50.5 1.0 CD2 A:HIS295 4.4 48.2 1.0 N A:HIS295 4.4 48.2 1.0 C A:ASN300 4.5 48.1 1.0 N A:ILE307 4.5 42.1 1.0 CA A:HIS295 4.8 48.2 1.0 CA A:CYS310 4.8 45.1 1.0 N A:CYS310 4.8 45.1 1.0 CA A:ILE307 4.9 42.1 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:65.8 occ:1.00 ND1 A:HIS642 2.0 52.0 1.0 SG A:CYS487 2.3 56.4 1.0 SG A:CYS646 2.4 56.5 1.0 SG A:CYS645 2.5 59.6 1.0 CG A:HIS642 2.9 52.0 1.0 CE1 A:HIS642 3.0 52.0 1.0 CB A:HIS642 3.2 52.0 1.0 CB A:CYS487 3.2 56.4 1.0 N A:CYS487 3.4 56.4 1.0 CB A:CYS646 3.5 56.5 1.0 CB A:CYS645 3.7 59.6 1.0 CA A:CYS487 3.9 56.4 1.0 C A:CYS645 3.9 59.6 1.0 N A:CYS646 4.0 56.5 1.0 CD2 A:HIS642 4.0 52.0 1.0 CE1 A:PHE571 4.0 53.3 1.0 NE2 A:HIS642 4.1 52.0 1.0 O A:CYS645 4.1 59.6 1.0 CA A:HIS642 4.2 52.0 1.0 CA A:CYS646 4.2 56.5 1.0 NZ A:LYS532 4.3 57.9 1.0 CD1 A:PHE571 4.4 53.3 1.0 CA A:CYS645 4.4 59.6 1.0 C A:GLY486 4.4 48.8 1.0 CA A:GLY486 4.6 48.8 1.0 CE A:LYS532 4.6 57.9 1.0 O A:HIS642 4.9 52.0 1.0 N A:CYS645 4.9 59.6 1.0 CZ A:PHE571 5.0 53.3 1.0

Q.Peng, R.Peng, S.Yi. Cryo-Em Structure of Favipiravir Bound to Replicating Polymerase Complex of Sars-Cov-2 in the Pre-Catalytic State. To Be Published.