Zinc in PDB 7c0m: Human Cgas-Nucleosome Complex

All present enzymatic activity of Human Cgas-Nucleosome Complex:
2.7.7.86;

The binding sites of Zinc atom in the Human Cgas-Nucleosome Complex (pdb code 7c0m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Cgas-Nucleosome Complex, PDB code: 7c0m:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Cgas-Nucleosome Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Cgas-Nucleosome Complex within 5.0Å range: probe atom residue distance (Å) B Occ K:Zn601 b:0.5 occ:1.00 SG K:CYS397 2.2 0.2 1.0 SG K:CYS396 2.2 0.7 1.0 SG K:CYS404 2.3 0.8 1.0 NE2 K:HIS390 2.4 0.2 1.0 CB K:CYS397 2.6 0.2 1.0 N K:CYS397 2.8 0.2 1.0 CA K:CYS397 3.2 0.2 1.0 C K:CYS396 3.2 0.7 1.0 CD2 K:HIS390 3.2 0.2 1.0 CB K:CYS396 3.4 0.7 1.0 CE1 K:HIS390 3.4 0.2 1.0 CB K:CYS404 3.7 0.8 1.0 O K:CYS396 3.8 0.7 1.0 CA K:CYS396 3.8 0.7 1.0 N K:CYS404 4.0 0.8 1.0 O K:GLU402 4.1 0.8 1.0 CA K:CYS404 4.4 0.8 1.0 CG K:HIS390 4.4 0.2 1.0 ND1 K:HIS390 4.5 0.2 1.0 C K:CYS397 4.6 0.2 1.0 C K:CYS404 5.0 0.8 1.0

Zinc binding site 2 out of 2 in the Human Cgas-Nucleosome Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Cgas-Nucleosome Complex within 5.0Å range: probe atom residue distance (Å) B Occ k:Zn601 b:0.5 occ:1.00 SG k:CYS397 2.2 0.2 1.0 SG k:CYS396 2.2 0.7 1.0 SG k:CYS404 2.3 0.8 1.0 NE2 k:HIS390 2.4 0.2 1.0 CB k:CYS397 2.6 0.2 1.0 N k:CYS397 2.8 0.2 1.0 CA k:CYS397 3.2 0.2 1.0 C k:CYS396 3.2 0.7 1.0 CD2 k:HIS390 3.2 0.2 1.0 CB k:CYS396 3.4 0.7 1.0 CE1 k:HIS390 3.4 0.2 1.0 CB k:CYS404 3.7 0.8 1.0 O k:CYS396 3.8 0.7 1.0 CA k:CYS396 3.8 0.7 1.0 N k:CYS404 4.0 0.8 1.0 O k:GLU402 4.1 0.8 1.0 CA k:CYS404 4.4 0.8 1.0 CG k:HIS390 4.4 0.2 1.0 ND1 k:HIS390 4.5 0.2 1.0 C k:CYS397 4.6 0.2 1.0 C k:CYS404 5.0 0.8 1.0

T.Kujirai, C.Zierhut, Y.Takizawa, R.Kim, L.Negishi, N.Uruma, S.Hirai, H.Funabiki, H.Kurumizaka. Structural Basis For the Inhibition of Cgas By Nucleosomes. Science V. 370 455 2020.
ISSN: ESSN 1095-9203
PubMed: 32912999
DOI: 10.1126/SCIENCE.ABD0237