Zinc in PDB 7btf: Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition

The binding sites of Zinc atom in the Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition (pdb code 7btf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition, PDB code: 7btf:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:59.1 occ:1.00 ND1 A:HIS295 2.6 37.7 1.0 SG A:CYS301 2.8 43.7 1.0 SG A:CYS310 2.8 37.2 1.0 SG A:CYS306 2.9 40.4 1.0 CB A:HIS295 3.3 37.7 1.0 CG A:HIS295 3.4 37.7 1.0 O A:CYS306 3.6 40.4 1.0 CB A:CYS301 3.6 43.7 1.0 CB A:CYS310 3.6 37.2 1.0 CA A:CYS301 3.7 43.7 1.0 CE1 A:HIS295 3.7 37.7 1.0 CB A:CYS306 4.0 40.4 1.0 C A:CYS306 4.0 40.4 1.0 N A:HIS295 4.2 37.7 1.0 CA A:HIS295 4.3 37.7 1.0 N A:CYS301 4.4 43.7 1.0 CA A:CYS306 4.6 40.4 1.0 O A:HIS295 4.6 37.7 1.0 CD2 A:HIS295 4.6 37.7 1.0 N A:ILE307 4.7 37.6 1.0 NE2 A:HIS295 4.7 37.7 1.0 O A:ASN300 4.8 42.3 1.0 C A:ASN300 4.9 42.3 1.0 C A:CYS301 4.9 43.7 1.0 CA A:CYS310 5.0 37.2 1.0 CA A:ILE307 5.0 37.6 1.0 N A:LEU302 5.0 42.8 1.0 C A:HIS295 5.0 37.7 1.0

Zinc binding site 2 out of 2 in the Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Rna-Dependent Rna Polymerase in Complex with Cofactors in Reduced Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:65.5 occ:1.00 SG A:CYS487 2.3 45.8 1.0 ND1 A:HIS642 2.5 43.5 1.0 SG A:CYS646 2.7 49.2 1.0 SG A:CYS645 2.8 50.7 1.0 CG A:HIS642 3.1 43.5 1.0 CB A:CYS487 3.4 45.8 1.0 CE1 A:HIS642 3.4 43.5 1.0 CB A:HIS642 3.4 43.5 1.0 N A:CYS487 3.5 45.8 1.0 CE1 A:PHE571 3.9 41.7 1.0 CA A:CYS487 3.9 45.8 1.0 CB A:CYS646 4.0 49.2 1.0 CB A:CYS645 4.1 50.7 1.0 CD2 A:HIS642 4.2 43.5 1.0 CD1 A:PHE571 4.2 41.7 1.0 C A:GLY486 4.2 43.9 1.0 NE2 A:HIS642 4.3 43.5 1.0 CA A:HIS642 4.5 43.5 1.0 N A:CYS646 4.6 49.2 1.0 CA A:GLY486 4.6 43.9 1.0 CZ A:PHE571 4.8 41.7 1.0 NZ A:LYS532 4.9 38.4 1.0 C A:CYS645 4.9 50.7 1.0 CA A:CYS646 4.9 49.2 1.0

Y.Gao, L.Yan, Y.Huang, F.Liu, Y.Zhao, L.Cao, T.Wang, Q.Sun, Z.Ming, L.Zhang, J.Ge, L.Zheng, Y.Zhang, H.Wang, Y.Zhu, C.Zhu, T.Hu, T.Hua, B.Zhang, X.Yang, J.Li, H.Yang, Z.Liu, W.Xu, L.W.Guddat, Q.Wang, Z.Lou, Z.Rao. Structure of Rna-Dependent Rna Polymerase From 2019-Ncov, A Major Antiviral Drug Target Biorxiv 2020.
DOI: 10.1101/2020.03.16.993386