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Zinc in PDB 7b83: Structure of Sars-Cov-2 Main Protease Bound to Pyrithione ZincEnzymatic activity of Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc
All present enzymatic activity of Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13; Protein crystallography data
The structure of Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc, PDB code: 7b83
was solved by
S.Guenther,
P.Reinke,
D.Oberthuer,
O.Yefanov,
L.Gelisio,
H.Ginn,
J.Lieske,
M.Domaracky,
W.Brehm,
A.Rahmani Mashour,
T.A.White,
J.Knoska,
G.Penaesperanza,
F.Koua,
A.Tolstikova,
M.Groessler,
P.Fischer,
V.Hennicke,
H.Fleckenstein,
F.Trost,
M.Galchenkova,
Y.Gevorkov,
C.Li,
S.Awel,
L.X.Paulraj,
N.Ullah,
S.Falke,
B.Alves Franca,
M.Schwinzer,
H.Brognaro,
N.Werner,
M.Perbandt,
H.Tidow,
B.Seychell,
T.Beck,
S.Meier,
J.J.Doyle,
H.Giseler,
D.Melo,
I.Dunkel,
T.J.Lane,
A.Peck,
S.Saouane,
J.Hakanpaeae,
J.Meyer,
H.Noei,
P.Gribbon,
B.Ellinger,
M.Kuzikov,
M.Wolf,
L.Zhang,
C.Ehrt,
J.Pletzer-Zelgert,
J.Wollenhaupt,
C.Feiler,
M.Weiss,
E.C.Schulz,
P.Mehrabi,
B.Norton-Baker,
C.Schmidt,
K.Lorenzen,
R.Schubert,
H.Han,
A.Chari,
Y.Fernandez Garcia,
D.Turk,
R.Hilgenfeld,
M.Rarey,
A.Zaliani,
H.N.Chapman,
A.Pearson,
C.Betzel,
A.Meents,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7b83:
The structure of Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc
(pdb code 7b83). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc, PDB code: 7b83: Zinc binding site 1 out of 1 in 7b83Go back to Zinc Binding Sites List in 7b83
Zinc binding site 1 out
of 1 in the Structure of Sars-Cov-2 Main Protease Bound to Pyrithione Zinc
Mono view Stereo pair view
Reference:
S.Guenther,
P.Reinke,
D.Oberthuer,
O.Yefanov,
L.Gelisio,
H.Ginn,
J.Lieske,
W.Brehm,
A.Rahmani Mashour,
J.Knoska,
G.Pena Esperanza,
F.Koua,
A.Tolstikova,
M.Groessler,
H.Fleckenstein,
F.Trost,
M.Galchenkova,
Y.Gevorkov,
C.Li,
S.Awel,
L.X.Paulraj,
N.Ullah,
S.Falke,
B.Alves Franca,
M.Schwinzer,
H.Brognaro,
N.Werner,
M.Perbandt,
B.Seychell,
S.Meier,
H.Giseler,
D.Melo,
I.Dunkel,
T.J.Lane,
A.Peck,
S.Saouane,
J.Hakanpaeae,
J.Meyer,
H.Noei,
P.Gribbon,
B.Ellinger,
M.Kuzikov,
M.Wolf,
L.Zhang,
C.Ehrt,
J.Pletzer-Zelgert,
J.Wollenhaupt,
C.Feiler,
M.Weiss,
E.C.Schulz,
P.Mehrabi,
B.Norton-Baker,
C.Schmidt,
K.Lorenzen,
R.Schubert,
H.Han,
A.Chari,
Y.Fernandez Garcia,
R.Hilgenfeld,
M.Rarey,
A.Zaliani,
H.N.Chapman,
A.Pearson,
C.Betzel,
A.Meents.
Massive X-Ray Screening Reveals Two Allosteric Drug Binding Sites of Sars-Cov-2 Main Protease Biorxiv 2020.
Page generated: Mon Jan 25 16:42:12 2021
DOI: 10.1101/2020.11.12.378422 |
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